Browsing by Author "Eriksson, Karl"

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    Infectious complications after transrectal ultrasound guided prostate biopsy in a prostate cancer screening trial
    (2022-05-23) Eriksson, Karl; University of Gothenburg / Institute of Medicine; Göteborgs universitet / Institutionen för medicin
    Background: Globally, prostate cancer is the second most diagnosed cancer among men. Prostate biopsies are necessary to obtain a histological diagnosis. Prostate biopsies can lead to different complications. Minor complications include hematuria, hematochezia, hematospermia and urinary tract infections. Major complications are uncommon and consists mainly of rectal bleeding and sepsis. This study investigates the infectious complication rate after transrectal prostate biopsy in a screening population. Materials & Methods: For this study, data was taken from the Göteborg prostate cancer screening 2 trial study. The study population consisted of 810 men aged 50-60 years. All men were asked to answer questionnaires prior and post prostate biopsy. Questionnaires consisted of questions regarding basic health characteristics and whether the patient had suffered any complications post biopsy. Some questionnaires lacked information, therefore a total of 207 medical charts were reviewed. The primary outcome for this study was to evaluate the infectious rate post biopsy. The secondary outcome was to investigate whether there was a difference in infection rates between systematic and targeted biopsies and furthermore the cause for the infections. This study is approved by the Regional Ethical Review Board in Gothenburg, January 2015 (registration number 890-14). Results: A large proportion of men in the questionnaire group were asymptomatic (7.8%) or had mild lower urinary tract symptoms (34.5%). Median age was 58.7 years. Out of the total study population of 810 men, infectious complications rate after transrectal biopsies in the population-based Göteborg prostate cancer screening 2-trial resulted in 1.7% patients with urinary tract infection (UTI) and 0.5% needing hospital care due to UTI. There was no significant result regarding biopsy approach and infection rates. Conclusion: Infectious complications post transrectal biopsy are rare in a screening population in men aged 50-60 years. These results can be used as a reference for further screening studies as well as in clinical practice.