Browsing by Author "Hattab, Suhaib"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    Kognitiv förmåga hos patienter med bipolär sjukdom: vilken roll spelar genetisk belastning för kliniska utfall?
    (2022-02-24) Hattab, Suhaib; University of Gothenburg / Institute of Medicine; Göteborgs universitet / Institutionen för medicin
    Institution: Department of neuroscience and physiology, Gothenburg University City: Gothenburg, Sweden Background: Bipolar disease is a chronic disease which is distinguished by mood swings. A patients mood can fluctuate between being depressive, manic or euthymic. Although the etiology for bipolar disease isn’t completely mapped, research has shown that both genetic and environmental factors contribute to developing the disease. However, there hasn’t been much research about how cognitive ability and genetic factors can impact the severity of the disease. Aim: This project primarily aims to investigate how premorbid cognitive ability affects clinical outcomes in bipolar patients. Secondly, we want to investigate whether bipolar patients with a heavy genetic load for schizophrenia are particularly sensitive to low cognitive ability. Methods: Materials and data analyzed in this study were taken from SWEBIC which is a study on bipolar syndrome. Our study population initially consisted of 808 participants. 20 people were excluded because there was no documented data on the variables we studied. individual data were collected about the patients in the form of implemented interventions and clinical results such as Global assessment of functioning / symptoms (GAF-S) and function (GAF-F ). Results: We found that premorbid cognitive ability correlates with a patients overall functioning (GAF-F), where lower premorbid intelligence showed lower functioning with a P-value 0,018. We also got statistically significant results regarding the correlation between low premorbid intelligence and genetic burden and hospital admissions. Regarding our other question at issue, we found no significant results indicating low premorbid cognition and heavy genetic burden correlates with development of schizophrenia. Conclusion: This study implicates that low premorbid cognitive ability and high genetic burden causes lower functioning in the patients suffering from the disease. It also implicates that these patients often require more hospital care than patients with higher cognitive abilities. However, lack of plurality of studies in the area indicates that it is still uncharted territories that require more studying.