Browsing by Author "Linder, Anna"
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Item Evaluation of regulator of G-protein signaling 2 (RGS2) at different stages of prostate cancer - Significance and clinical potential(2019-05-15) Linder, AnnaProstate cancer (PC) is often a slow-growing and symptom-free disease with good prognosis. However, a substantial number will progress, ultimately metastasize if left untreated and finally kill the patient. The standard treatment for these stages of PC is androgen deprivation therapy (ADT), which generally has an initially good clinical response. However, ADT drives development of highly aggressive forms of castration-resistant PC (CRPC) and promote development of bone metastases. Thus, early detection of resistance is invaluable considering the incurability of these stages once they are established. The purpose of the present thesis was to assess the regulation and significance of regulator of G-protein signaling (RGS2) in PC; with focus on PC progression, and development of CRPC and bone metastases. Furthermore, evaluate its potential as a prognostic biomarker for hormonenaïve prostate cancer (HNPC) and in association to development and progress of CRPC. This, as the new era of treatment options calls for stable reliable biomarkers for adequate treatment decisions. The principal findings from this work suggest that, RGS2 was highly expressed in both advanced HNPC and CRPC. The significance of this was reflected by the association between high levels of RGS2 and poor clinical outcome in both of these stages. Moreover, experimental data suggest that RGS2 expression is regulated by hypoxia and HIF1. The implication of different levels of RGS2 was assessed with RGS2 knockdown in the PC cell line LNCaP. The results show that low and high RGS2 expressing PC cells have distinct PC phenotypes, resembling early low-risk tumors and advanced PC, respectively. Furthermore, the data suggests that by mediating the effect of hypoxia, RGS2 has significant tumor promoting roles in HNPC. Additionally, induced RGS2 expression, in response to ADT, was found predictive of decreased time to relapse in association with resumed androgen-receptor (AR) signaling. The stromal expression of RGS2 display a contrasting expression pattern compared to the epithelial, with decreased expression in association with more advanced disease, the relevance of this was suggested by a prognostic property of stromal RGS2 expression. Finally, high RGS2 expression levels were noticed in human PC bone metastases, and found to be essential for the tumor cells ability to establish in the bone, as well as endorsing of the sclerotic phenotype that is associated with PC bone metastases. In conclusion, the present thesis suggests a tumor-promoting function for RGS2, associated with PC progress and development of CRPC and PC bone metastases. Furthermore, the results suggest that RGS2 has potential as a prognostic and treatment-predictive biomarker in PC.Item Genustrubbel på 70-talet: När kvinnorörelsen greppade filmkameran(2014-09-17) Ryberg, Ingrid; Linder, AnnaItem House of Words (HoW) - Queerness(2015-11-21) Linder, AnnaItem Queera rörliga bilder(2017-02-02) Linder, AnnaItem Spermahoran - Spermwhore(2016-01-29) Linder, AnnaItem The Curator as a Collector(2012-01-02) Linder, Anna; University of Gothenburg/The school of Film Directing; Göteborgs universitet/FilmhögskolanOm lusten att samla på sig saker och om lusten att visa sin samling. Att synliggöra en smak, en kunskap, ett intresse för andra. Om processer och tankar kring ett arbete där själva visningen av det insamlade materialet bildar (blir) (är) en tillgänglig rörlig samling, ett privat mobilt arkiv, ett levande nätverk. Är det en bekräftelse i sig att publiken kommer och tittar eller krävs det mer? Ett samtal kring upplevelsen eller bara ett utrymme för samtal efter det upplevda.Item Transfer of Export Process from Customer to Supplier -The Case of Volvo do Brasil-(2004) Martínez Majander, Ulla; Linder, Anna; Göteborgs universitet/Graduate Business SchoolThis thesis explores the issues around the export process transfer from customer to supplier, namely Volvo do Brasil and local suppliers. The purpose has been to generate an understanding of the factors that enable the transfer of the process in a matter where mutual gain can be obtained. The theoretical framework of the study is based on a behaviouristic view to the process transfer issue. The theoretical discussion focuses on the relational aspects in process transfer. The section is concluded with a model that summarises the factors affecting process transfer in an emerging market context. The empirical section of the study includes findings where all perspectives of the parties involved are presented. The findings indicate that the relational aspects form a basis to the process transfer and subsequent strategy implementation. However, these factors alone do not grant that the target supplier is able to implement direct exporting. In conclusion, it has been found that the transfer of the export process requires communication routines and clear role division between the affiliate and headquarters (HQ). Moreover, it has been found that ability depends on the willingness and the capability of the supplier.