Browsing by Author "Stouten, H"

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    DECOS and SCG Basis for an Occupational Standard Cresols (o-, m-, p-)
    (Arbetslivsinstitutet, 1998) Stouten, H
    Cresols occur as crystalline solid to colourless to yellowish liquid. They are slightly soluble in water and soluble in organic solvents. There are no data on the absorption of cresols in humans. In vivo animal data indicate that most of the administered dose (gavage) is absorbed and excreted in the urine, mainly as conjugates. The oxidative metabolism of p-cresol in rat liver microsomes proceeds differently from that of the other isomers. The critical effect of cresol vapours is local irritation.
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    DECOS and SCG Basis for an Occupational Standard Isopropyl acetate
    (Arbetslivsinstitutet, 1997) Stouten, H
    Isopropyl acetate is a colourless liquid with a fruity odour. It is soluble in water andacetone and miscible with alcohol and ether. Its vapour is heavier than air. Methods for personal air sampling are available. No data were available on the kinetics of isopropyl acetate. It can be expected that it will hydrolyse to acetic acid and isopropanol in the liver and the respiratory tract. Human data on effects are limited to old data concerning irritation. From lethality data following single exposure to animals, it can be seen that isopropyl acetate is hardly toxic via the various exposure routes. No experimental animal studies were allocated regarding effects following repeated exposure. Isopropyl acetate was negative in most genotoxic test systems, but was a weak inducer of aneuploidy. Based on the few existing data, the critical effect of occupational exposure to isopropyl acetate is irritation.