Browsing by Author "Stouten, H."

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The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee on Occupational Standards : 126. 1,2,3-Benzotriazole
(Arbetslivsinstitutet, 2000) Stouten, H.; Rutten, A.A.J.J.L; Gevel, I.A. van de; Vrijer, F. De
Benzotriazole is an odourless, white to tannish crystalline powder. It is sparingly soluble in water and soluble in a number of organic solvents. It has a low vapour pressure, and it is therefore likely to occur as dust at the workplace. When finely divided and mixed with air, dust explosions may occur. Benzotriazole is an industrial compound primarily used as a corrosion inhibitor, as a plastic stabiliser, and as a chemical intermediate. There is very little information found with respect to the toxicokinetics of benzotriazole. Based on experimental animal data with benzotriazole of unknown purity and limited human data, it is concluded that benzotriazole is slightly irritating to the eyes and, at most, slightly irritating to the skin Benzotriazole is considered not to be a skin sensitiser. In the carcinogenicity studies, higher incidences of : mostly benign : tumours in some organs were observed in treated than in concurrent control animals. These tumours had mostly higher incidences in the low-dose than in the high-dose group, and occurred at fairly high rates in historical controls. The LOAELs were set at 295 and 1455 mg/kg bw/day in rats and mice, respectively. In view of the inconclusive evidence for carcinogenic potential of benzotriazole in rodents and the mutagenic effects of benzotriazole in bacterial systems along with the absence of mutagenic and genotoxic effects in vitro in mammalian cells and in vivo in experimental animals, the data base is too poor to justify a conclusion regarding genotoxicity and carcinogenicity of this chemical.