Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet: Recent submissions
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Towards restoring intestinal health after pelvic radiotherapy - Lessons from dietary fiber intervention in a novel mouse model
(2019-11-18)Patients who have cancer in the pelvic region are at risk of developing gastrointestinal symptoms for weeks, months, or even years after receiving radiotherapy. These symptoms are triggered due to unwanted radiation-induced ... -
Health-Related Quality of Life and Growth Hormone Treatment
(2019-11-18)Introduction Growth Hormone (GH) is used to increase height in Turner Syndrome (TS), the most common sex-chromosome aberration in women. GH is also beneficial for bone mass. However, little is known about how GH treatment ... -
The Swedish Infant High-grade Reflux Trial - and a Focus group study of parents’ experiences
(2019-11-18)Background: Vesicoureteral reflux (VUR) is a pathological back-flow of urine from the bladder to the ureter and renal pelvis. VUR is associated with an increased risk of urinary tract infections (UTI) and renal damages. ... -
Taurine and dopamine-related effects of ethanol. An experimental study in rodents
(2019-11-18)The reinforcing properties of alcohol (ethanol) are associated with activation of the mesolimbic dopamine system and the concomitant increase in dopamine in the nucleus accumbens (nAc). Changes in this system are thought ... -
Body mass index and mental health in young people - predictors of early heart failure and cardiomyopathy
(2019-11-18)Heart failure among young people is rare, but in contrast to decreasing incidence rates overall, recent studies have found increasing rates among the young over the last decades. Concomitantly, cardiomyopathies, which ... -
In vitro models of the blood brain-barrier using iPSC-derived cells
(2019-11-18)The blood-brain barrier (BBB) constitutes the interface between the blood and the brain tissue. Its primary function is to maintain the tightly controlled microenvironment of the brain. Models of the BBB are useful for ... -
Intestinal preservation for transplantation: translational approaches
(2019-11-13)Background: Intestinal preservation injury (IPI) may result in various degrees of mucosal damage, which may later favor bacterial translocation, post-reperfusion syndrome, and upregulation of alloreactivity. Experimental ... -
Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action
(2019-11-13)Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis ... -
Cardiac lipids and their role in the diseased heart
(2019-11-13)Lipids play an essential role within the heart as they are involved in energy storage, membrane stability and signaling. Changes in cardiac lipid composition and utilization may thus have profound effects on cardiac ... -
Temporomandibular disorders in women—symptoms and signs in population-based studies
(2019-11-13)The overall aim of this thesis was to investigate symptoms and signs of temporomandibular disorders (TMD) and orofacial pain in the Swedish female population in relation to some other health factors. The thesis includes ... -
Regulation of gut IgA induction by helper T cells
(2019-11-12)The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to the outside world, it also functions as the most important portal of entry for many pathogens. T cell-dependent secretory immunoglobulin ... -
Hepatitis E virus in the virome of water and animals
(2019-11-12)This thesis was aimed to investigate viruses in different animals and water to get some understanding of viruses that disseminate into the environment. Next generation sequencing (NGS) was used to explore the virome from ... -
Bedömning i samverkan - en väg till remission vid schizofreni
(2019-11-11)Background: The process from assessment of symptoms and function to various efforts in psychiatric outpa-tient care is still a "black box". Our knowledge of the connection between processes in care and the patient's status ... -
Understanding the role of long non-coding RNAs in neuroblastoma development and progression
(2019-11-11)Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to ... -
Microcrystallization in lipidic cubic phase and serial crystallography studies of cytochrome c oxidase
(2019-11-07)Life in all living organisms depend on chemical processes performed by proteins, which are molecular machineries encoded in the DNA. Cytochrome c oxidase (CcO) is a membrane protein essential for cellular respiration, a ... -
Factors influencing outcome in patients with obstructive hypertrophic cardiomyopathy - Effects of pharmacotherapy, pacing and surgical myectomy
(2019-11-07)Background: Most studies on risk factors for disease-related mortality in hypertrophic cardiomyopathy (HCM) have emanated from specialized tertiary centres which are subject to possible referral bias. About one quarter of ... -
Patient Perspectives brought to the Fore for Diabetes Care: Descriptions as well as Development and Testing of the Diabetes Questionnaire
(2019-11-07)Aim: The overall aims were to describe perspectives of living with diabetes, to develop a patient-reported outcome and experience measure for the Swedish National Diabetes Register, and to initiate the evaluation of evidence ... -
Tonsil Surgery - Register Studies of Complications and Outcomes
(2019-11-07)Tonsillectomy is a commonly performed surgical procedure yet the evidence of the effect in patients with recurrent/chronic throat infections is unsatisfactory. Great variations exist in the reported rates of postoperative ... -
Designing for learning and knowing: Nurses in chronic care and patients' self-monitoring data
(2019-11-06)This thesis focuses on nurses’ work practice in chronic care and their learning and knowing in relation to their patients’ self-monitoring data. It is anticipated that self-monitoring data used as a support for healthcare ... -
Cardiac abnormalities in chronic kidney disease
(2019-11-06)Chronic kidney disease (CKD) is a global health problem associated with increased risk of mortality and development of end-stage renal disease (ESRD). Cardiovascular diseases are the leading cause of morbidity and mortality ...