Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi: Recent submissions
Now showing items 81-100 of 163
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Computational Studies of UV-B Induced Signalling Pathways in Plants
(2017-05-18)Abstract This thesis presents theoretical studies of UV-B induced signaling pathways in plants using molecular dynamic methods combined with (TD)-DFT calculations. Ultraviolet B (UV-B) radiation is a component of sunlight ... -
Ultrafast Structural Changes in a Bacterial Photosynthetic Reaction Center probed with XFEL Radiation
(2017-05-12)Photosynthesis is the process by which plants and many species of bacteria convert energy from sunlight into chemical energy used to power their metabolism. As these plants and bacteria are eaten, the chemical energy moves ... -
Energy efficiency in the sodium chlorate process: From electrocatalysis to pilot plant investigations
(2017-04-24)Sodium chlorate is an important industrial chemical produced through an electrochemical manufacturing process. The global production rate is 3.6 million tons annually and consumes approximately 20 TWh of electrical power. ... -
Interrogation of Biological Samples by ToF-SIMS using New Primary Ion Beams and Sample Preparation Methods
(2017-01-12)Mass spectrometry is a very versatile and important technique in analytical chemistry. From atomic bombs to Alzheimer’s disease, after a century of improvements and developments there are now countless applications for ... -
Dynamic regulation of the Mig1 transcriptional repressor under glucose de/repression
(2016-11-24)The budding yeast Saccharomyces cerevisiae AMP-activated protein kinase/SNF1 is a member of a highly conserved protein family present in all eukaryotes. Snf1 regulates energy homeostasis; in yeast, it is best-known for its ... -
Computer-aided drug design approaches in developing anti-cancer inhibitors
(2016-11-23)The thesis entitled “computer-aided drug design approaches in developing anti-cancer drug” is divided into a total of six chapters. In the first chapter, an overview of drug discovery and development are introduced. Nowadays, ... -
Systems-level investigation of the interaction between glucose metabolism and the Snf1/Mig1 signalling pathway
(2016-11-21)Saccharomyces cerevisiae Snf1 and its mammalian homolog, AMPK, are members of a protein kinase family present throughout the Eukaryotic kingdom. AMPK plays an essential role in different cellular processes and is involved ... -
Molecular pathways mediating the development of female germ cells
(2016-10-06)In mice, primordial germ cells (PGCs) dramatically increase in their number from 200 cells at 9.5 dpc to 10 000 cells at 12.5 dpc with doubling time of 12.6 hours. Thus, cell proliferation of PGCs seems a unique compared ... -
Towards Anti-Virulence Antimicrobials, Discovery and Development of Sortase A Inhibitors and Investigations of Bacterial Phenotypes
(2016-09-07)Antibiotic resistance is an emerging and serious threat to public health. Immediate actions are required to preserve current antibiotics while intensifying research efforts towards the development of new effective therapeutics. ... -
Lanthanide-mediated C-F Bond Activation Method Development and Mechanistic Investigation
(2016-08-23)The use of transition-metals and main-group Lewis acids has proven to be an outstanding source for activation and subsequent functionalization of fluorinated compounds. However, the first is mainly limited to C(sp2)–F bonds ... -
Ion Solvation in Critical Binary Aqueous Solvents Probed by Advanced Synchrotron-Based Techniques
(2016-05-20)The Poisson-Boltzmann equation is the standard tool for studying the electrostatic interactions in electrolyte solutions, although it neglects e.g. the ion size and ion-ion correlations. Even experimentally observed specific ... -
Cellular Responses to Arsenite and Cadmium - Mechanisms of Toxicity and Defense in Saccharomyces cerevisiae
(2016-05-12)All biological systems have to cope with a wide range of metals that are present in the environment. Metals can be essential or beneficial for life, inert or non-essential and toxic, often depending on their chemical form ... -
C. elegans PAQR-2 ‒ A Regulator of Membrane Homeostasis
(2016-04-26)The progestin and adipoQ receptor (PAQR) protein family is characterized by a 7-transmembrane domain, and a topology reversed that of G-protein coupled receptors, i.e. the N-terminus resides in the cytoplasm. Despite the ... -
On the role of actin in yeast protein quality control
(2016-04-25)Every cell is equipped with a protein quality control system to ensure the proper function of proteins. This is essential for both cell maintenance and the generation of new and healthy cells. In this thesis, the budding ... -
The Extended Role of the Molecular Chaperone CCT
(2016-03-23)The oligomeric chaperone CCT is a large ATP-dependent chaperonin that consists of two rings placed back-to-back with eight different paralogous subunits with a size of ~ 55 kDa that sit in each of the two rings. The ... -
A Waterborne Colloidal Model System Consisting of Fluorinated Spheres Bearing Grafted PEG: Synthesis, Characterization and Properties
(2016-01-08)Model systems have expanded our knowledge of numerous phenomena in Colloid Science, such as the appearance of glasses, order-disorder transitions involving crystals and attraction induced formation of gels. So far, the ... -
Detecting and Identifying Solution-structural Change in Photoactive Proteins
(2015-11-27)Conformational dynamics allow proteins to fulfil their biological roles, yet the understanding of these molecular machines is largely limited to structural snapshots. Time-resolved X-ray scattering provides a possible way ... -
Human Aquaporins: Production, Characterization and Interactions
(2015-11-06)Membrane proteins are essential components of the cell and responsible for the communication with the outside environment and transport of molecules across the membrane. Water transport is facilitated by aquaporins, which ... -
Damage Segregation and Cellular Rejuvenation in Saccharomyces cerevisiae
(2015-11-06)The process of aging is defined as a time-dependent decline in cellular functionality, and aging is thought to have evolved as organisms were optimized for reproduction, at the cost of an imperfect repair and maintenance ... -
The Foxf2 gene in development and disease
(2015-10-29)The Foxf2 gene in development and disease Azadeh Reyahi Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, SE 405 30, Göteborg, Sweden Abstract In this thesis I present our recent data ...