Doctoral Theses from Sahlgrenska Academy: Recent submissions
Now showing items 261-280 of 2013
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Förekomst och behandling av smärta samt interventioner som bidrar till förbättrat smärtomhändertagande hos patienter på sjukhus
(2020-02-27)Background: Pain is common in hospitalized patients. Despite the availability of various treatment methods and effective drugs foroptimal pain alleviation, research has revealed that pain treatment remains suboptimal. Aim: ... -
The physiological processing of Alzheimer-associated amyloid beta precursor protein in human and animal-derived neuronal models
(2020-02-27)Alzheimer’s disease (AD) is characterized by cognitive impairment due to the loss of structure and/or function of neurons, and amyloid plaques composed of aggregated-amyloid beta (Aβ) peptides, primarily species ending at ... -
Ghrelin in feeding: new insights into its role and the neurocircuits involved
(2020-02-27)Appetite, originally evolved to ensure we consume enough of diverse nutrients to survive famines, has lost its survival advantage in our modern society, where food is plentiful. The hedonic aspect of appetite can indeed ... -
Cardiovascular outcomes and extra-articular manifestations in patients with spondyloarthritis
(2020-02-27)Background: Spondyloarthritis (SpA) is a cluster of rheumatic diseases with similar clinical features, including association with extra-articular manifestations such as anterior uveitis (AU), inflammatory bowel disease ... -
Periprosthetic femoral fracture after total hip replacement. Incidence, risk factors, and treatment
(2020-02-18)This thesis investigates the incidence of surgically treated periprosthetic femoral fractures (PPFF) in Sweden between 2001 and 2011, the demography of this population, risk factors that may contribute to its occurrence ... -
Bipolar disorders: Subtypes, treatments, and health inequalities
(2020-02-18)This thesis comprises five studies based on prospective, longitudinal data from the Swedish national quality register BipoläR. Study I examined the differences between bipolar subtype I and II with respect to clinical ... -
Tumor cell heterogeneity profiling using single-cell analysis
(2020-02-13)Cancer is a diverse disease with large variations between tumor types and patients regarding tumor progression and prognosis. Additionally, most individual tumors are heterogeneous, containing subpopulations of cells with ... -
Sex steroids, IGF-I, and vascular morphology from birth to adulthood in individuals born small for gestational age
(2020-02-11)Abstract Aim: To study whether there is an association between size at birth, sex steroids, IGF-I, and retinal vascular morphology. Patients and methods: Two different cohorts were studied. In paper I, 25 young adult men ... -
Outcome of Graves disease
(2020-02-05)Graves' disease (GD) is an autoimmune condition with elevated thyroid hormone levels and symptoms suggesting an affected brain. These symptoms often resolve with treatment but, for some patients, GD results in a long period ... -
Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials
(2020-01-30)Immunotherapy with PD-1 inhibitors has transformed the treatment of met-astatic cutaneous mela- noma, and can lead to complete and durable responses in a proportion of patients. However, in around half of the patients, the ... -
Health-economic evaluations of person-centred care
(2020-01-28)Person-centred care aims at making the individual partake in the healthcare decisionmaking and at supporting individual health management. This stands in contrast to usual care, which typically has more focus on the ... -
Febrile Seizures and associated neurodevelopmental disorder
(2020-01-22)Background: Febrile seizures (FS) are common in young children. There is a lack of knowledge about possible associations between FS and the child’s cognitive and behavioural development. Aim: Gain further insight into the ... -
The balancing act of living with symptoms. Patient-reported data and quality of care during and after treatment with proton beam therapy in patients with brain tumors
(2020-01-21)is thesis focuses on patients with primary brain tumors undergoing proton beam therapy (PBT) and the consequences of the treatment. Quality of care (QoC) in a recently established clinic in Sweden was also evaluated. ... -
On the role of genetic variation and epigenetics in hemostatic gene regulation
(2020-01-17)Many genetic variants have been identified to associate with circulating levels of hemostatic proteins and with thrombotic or hemorrhagic disorders. However, the underlying molecular mechanisms remain largely unknown. ... -
Perspectives on urban wastewater as a source of microbial pollution
(2020-01-17)Wastewater treatment plants are important links for dissemination of intestinal bacteria into surface waters. In this study, twelve mallards were exposed to treated wastewater for a period of 55 days. Faecal samples were ... -
Radiological and Clinical Changes in Idiopathic Normal Pressure Hydrocephalus: MRI, Vascular factors and Clinical Symptoms as Markers of Pathophysiology and Prognosis
(2020-01-15)Idiopathic normal pressure hydrocephalus (iNPH) is a treatable, neurological disorder affecting the elderly population causing gait, balance, cognitive and micturition impairments. Treatment results in a clinical improvement ... -
Epidemiological Aspects on Assessing and Treating Dyslipidemia in Type 1 Diabetes
(2020-01-08)Background: Cardiovascular disease (CVD) is a major cause of shortened longevity in individuals with type 1 diabetes. Dyslipidemia is one of the important modifiable risk factors. Aims: To investigate different aspects ... -
Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury
(2020-01-07)Perinatal complications such as asphyxia can cause brain injuries that are often associated with subsequent neurological deficits. The mechanisms of perinatal brain injury are not fully understood, but mitochondria play a ... -
Pain in Osteoarthritic Joints: Biological Signaling and 3D Models based on Imaging
(2019-12-19)Osteoarthritis (OA) is the most common joint disease, causing disability in middle-aged and elderly patients worldwide and imposing a huge socioeconomic burden. OA of the knee joint is a major cause of joint pain and, along ... -
Hepatitis B virus RNA in serum and liver tissue - quantification using digital PCR
(2019-12-19)Hepatitis B virus (HBV) infection is a global health issue that is responsible for approximately 900,000 deaths each year, by inducing liver cirrhosis and hepatocellular carcinoma (HCC). A few markers are used to classify ...