Samband mellan obalans i det autonoma nervsystemet, mätt som Heart Rate Recovery, och faktorer i det metabola syndromet.

Abstract

Abstract Degree Project thesis, Programme in medicine, 2015 Title: Relationship between perturbation in the autonomic nervous system, measured as Heart Rate Recovery, and factors included in the metabolic syndrome. Author: Anna Rutgersson Institution: Department of neuroscience and physiology, Institution of medicine Sahlgrenska Academy, University of Gothenburg, Sweden Keywords: neurohormonal stress system, Heart Rate Recovery, metabolic syndrome Introduction Our neurohormonal stress system consists mainly of the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal axis (HPA axis). The two systems interact strongly with one another. Prolonged stress can cause perturbations in the regulation of the HPA-axis and the ANS. This can lead to development of central obesity, impaired glucose tolerance, insulin resistance, dyslipidemia and elevated blood pressure, abnormalities included in the metabolic syndrome. Perturbation in ANS (the balance between the sympathetic and the parasympathetic activation) may be measured using an objective, non-invasive method called Heart Rate Recovery (HRR). Mental disorders are increasing in Sweden. Stress related diagnoses are dominating the picture. Increased knowledge about associations between HRR and factors included in the metabolic syndrome could contribute in the search of objective stress biomarkers. Aim Elucidate possible relationships between perturbation in ANS, measured as heart rate recovery, and risk factors for developing the metabolic syndrome. Method We examined 42 healthy women who participated in the research study SIBIRIEN. A submaximal cycle ergometer test was performed to measure HRR. Factors included in the metabolic syndrome were measured and correlated to HRR. Results Women with a rapid HRR in the early phase of recovery showed higher levels of both total cholesterol and LDL. Higher concentrations of triglycerides were seen in women with a rapid HRR, both in the early and late phase of recovery. Women with a rapid HRR, during most of the recovery period, showed a tendency to higher systolic blood pressure, although not statistically significant. Conclusion Our results suggest that factors in the metabolic syndrome are reflected in HRR.