Sahlgrenska Academy / Sahlgrenska akademin: Recent submissions
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Chronic Achilles Tendon Rupture - Perspectives on outcomes after surgical treatment and rehabilitation
(2022-05-04)Chronic Achilles tendon rupture (CATR) is a rupture of the Achilles tendon for which adequate diagnosis and treatment has been delayed after index injury. In this thesis defined as 4 weeks or more. The delay is commonly ... -
New Risk Factors in Poststroke Epilepsy
(2022-05-04)The overall aim of the present research was to identify new risk factors for poststroke epilepsy (PSE). Specifically, we wanted to assess the impact of having a first-degree relative with epilepsy on PSE risk (Paper I), ... -
Cognitive, emotional and psychosocial functions after resective epilepsy surgery
(2022-05-02)Epilepsy surgery is a potentially curing treatment for a selected group of patients with drug-resistant focal epilepsy. Cognitive side-effects after temporal lobe resections (TLR) are well documented but it is still difficult ... -
Hypertension, atherosclerosis and fracture risk - observational investigations with focus on antihypertensive therapy
(2022-04-28)Aim: To investigate associations between hypertension, arteriosclerotic disease, and fracture risk in adults and the elderly, with a certain focus on how specific antihypertensive drug treatments in patients with high blood ... -
Gallstone-related symptoms and quality-of-life in patients undergoing gallstone surgery - The Gothenburg Gallstone Questionnaire (GGQ24)
(2022-04-28)Background: Patients with symptomatic gallstone disease can present with years of intermittent suffering or acute complicated disease. The only definitive cure is surgery. Registering both surgical and patient reported ... -
Molecular and structural studies of proteins required for mitochondrial DNA maintenance
(2022-04-28)Mitochondria are membrane-bound organelles that produce the majority of ATP used to drive metabolic processes in eukaryotic cells. A unique feature of mitochondria is the existence of a separate mitochondrial DNA (mtDNA), ... -
Clinical challenges in Cushing's syndrome
(2022-04-28)Cushing’s syndrome (CS) is caused by prolonged exposure to cortisol excess. CS is associated with cardiovascular diseases, infections, and fractures, as well as with cognitive impairment and affective disorders. This thesis, ... -
Cause-Specific Mortality and Physical Fitness in Mental Disorders - Epidemiological and Internventional Studies
(2022-04-28)Mental illnesses are common and constitute a substantial health-related and financial burden on both the individual and society. Mental disorders in general have increased risk of somatic morbidity. An early age of onset ... -
Metopic synostosis - surgical results and perinatal aspects
(2022-04-27)Metopic synostosis (MS) is the second most common type of craniosynostosis (CS). This thesis aimed to evaluate surgical results in children operated for MS, their perinatal outcomes and potential etiological risk ... -
Hypertoniscreening - Tidig upptäckt av högt blodtryck via tandvården
(2022-04-25)Background: Hypertension is the main risk factor for the world’s total disease burden. This is of significance for public health at national level, for healthcare professionals, resource consumption and costs as well as ... -
Diving and the brain
(2022-04-25)Abstract Introduction There are reports that long-term diving is associated with cognitive impairments. This raises the question if diving itself is harmful to the brain in the absence of decompression sickness ... -
Thymic exosomes - effects on selection and maturation of thymocytes
(2022-04-22)T cell tolerance is primarily shaped in the thymus, through direct and indirect presentation of self-antigens to developing T cells. Medullary thymic epithelial cells (mTECs), producing and expressing self-antigens, together ... -
Centralized Ovarian Cancer Care - Complications, Costs and Survival
(2022-04-19)Background: Ovarian cancer is often diagnosed at advanced stages, and its mortality is high. Surgical treatment of advanced ovarian cancer strives toward complex primary debulking surgery (PDS), aiming for complete ... -
Designing, developing, and evaluating a person-centered support model for women with breast cancer treated with endocrine therapy
(2022-04-19)Breast cancer is the most common cancer among women worldwide. Approximately 70% of all breast cancers are estrogen positive and are recommended for treatment with adjuvant endocrine therapy (ET) for five to ten years, ... -
Health locus of control, depressive symptoms, and insulin resistance. Implications for treatment and prevention in general population and primary care
(2022-04-14)The disease burden of type 2 diabetes and depression is large and challenging for healthcare systems. Preventive interventions require resources and better knowledge concerning early stages in the development of these ... -
Cerebrospinal fluid studies of bipolar disorder
(2022-04-14)The pathophysiology of bipolar disorder remains to be elucidated. One approach to studying brain processes is analysis of cerebrospinal fluid (CSF). This thesis comprises five studies based on the Sankt Göran Bipolar Project ... -
Human papillomavirus infection and preterm delivery
(2022-04-11)Background: Persistent human papillomavirus (HPV) infection causes cervical intraepithelial neoplasia (CIN). Excisional treatment of CIN has been linked to increased risk of preterm delivery (PTD). The specific mechanism ... -
Valvular aortic stenosis in children. Outcome, physical activity and health-related quality of life
(2022-04-11)Introduction: Isolated valvular aortic stenosis (VAS) accounts for 3–5% of congenital heart disease and presents with a wide spectrum of severity. Critical VAS in the neonate is the most severe form, fatal in the absence ... -
The role of the gut microbiota in central energy balance regulation
(2022-04-11)The gut microbiota can affect development and metabolism in the host. Today, much is still unknown regarding the effects of the gut microbiota on central energy balance regulation. We used mouse models to determine the ... -
The Autism - Tics, ADHD and other Comorbidities inventory (A- TAC). Validity, reliability, and the measurement of autism in males and females
(2022-04-11)The Autism–Tics, ADHD and other Comorbidities inventory (A–TAC) is a broad-band screening instrument for neurodevelopmental disorder (e.g., autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), ...