Sahlgrenska Academy / Sahlgrenska akademin: Recent submissions
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Helicobacter spp. – host interaction in the mucus niche
(2018-11-30)Helicobacter pylori is the most common human gastric pathogen, colonizing half of the world's population. Helicobacter suis colonizes the stomach of 60-95% of pigs at slaughter age and it is the most prevalent non-Helicobacter ... -
Seroepidemiology of vaccine-preventable and emerging RNA viruses in Rwanda
(2018-11-28)Abstract Infectious diseases are a leading cause of death in sub-Saharan Africa, and in Rwanda diarrhea, lower respiratory and other common infections are linked to high mortality and morbidity. For children <5 years of ... -
Vitamin A and Bone: Studies in vivo and in vitro
(2018-11-28)Background: Excess vitamin A is associated with decreased cortical bone and increased risk of fractures in humans. The aim of the present thesis was to assess the importance of vitamin A on the skeleton and bone cells in ... -
Epidemiological studies in de novo and secondary acute leukemia
(2018-11-23)Abstract Background Acute leukemia (AL) is a rare blood cancer with poor prognosis in adult patients. Socioeconomic factors are known to impact cancer outcomes, but have not been adequately examined among adult AL patients. ... -
Natural History of Human Papillomavirus Infections and Other Sexually Transmitted Infections in Rwanda-Immunological Aspects of the Uterine Cervix
(2018-11-23)Objective: Cervical cancer stands for the predominant cause of cancer death among Rwandan women. Chronic Human Papillomavirus (HPV) infection constitutes the main risk factor. We here assessed the prevalence and incidence ... -
Achilles Tendon Ruptures Predictors; functional and economic impact
(2018-11-22)Acute Achilles tendon rupture is a common injury, which leads to significant morbidity in patients. Many patients never recover their full function even after long rehabilitation, whereas others make a good recovery. The ... -
Lung-resident, M2e-specific CD4 T cells critically protect during influenza infection
(2018-11-22)Memory CD4+ T cells are a critical component of the adaptive immune response to fight infection. However, current vaccines against influenza only focus on the other arm of adaptive immunity—triggering B cells to produce ... -
On the pathogenesis of infections associated with percutaneous osseointegrated orthopaedic implants
(2018-11-22)Orthopaedic implants enable the restitution of locomotor function and improve the quality of life of many people. However, biomaterial-associated infection may occur due to the propensity of microorganisms to adhere and ... -
Systematiska kunskapsöversikter; 13. Suicide in the employed population: A review of epidemiology, risk factors and prevention activities
(Arbets- och miljömedicin, Göteborgs universitet, 2018-11-21)This review described current evidence about the relationship between workplace exposures and suicidal outcomes, including thoughts about suicide, suicide attempts, and death due to suicide. First, an overview of suicide ... -
Platelet activation and aggregation: Clinical and experimental studies
(2018-11-21)Background: Dual antiplatelet therapy with acetylsalicylic acid (ASA) and the adenosine diphosphate (ADP)-receptor antagonist ticagrelor increases the risk of bleeding complications during cardiac surgery. The overall aim ... -
Health hazards and cancer in relation to occupational exposures among Swedish seafarers
(2018-11-19)This thesis explores health hazards for seafarers in the Swedish merchant fleet, and occupational risks for lung cancer, mesothelioma and hematologic malignancy (HM). A special focus has been exposure to benzene and biomarker ... -
Defining the importance of protein geranylgeranylation in innate immunity
(2018-11-19)RHO family proteins and other intracellular proteins are prenylated with a 20-carbon lipid—a product of the cholesterol synthesis pathway—by protein geranylgeranyltransferase type I (GGTase-I). Prenylation is widely believed ... -
Shoulder impingement; Evaluation of the clinical outcome, radiographic findings, histology, ultrastructure and biochemistry
(2018-11-16)This thesis had two main purposes: on the one hand, to assess and evaluate the clinical outcome of different treatment strategies for subacromial impingement syndrome (SAIS), in both the short and the long term and, on the ... -
Lung and chest wall properties during mechanical ventilation
(2018-11-16)Background: Mechanical ventilation causes injury to the lungs due to high pressures and high volumes. Pressure affecting the lungs, the transpulmonary pressure, needs to be monitored to minimise harmful side effects but ... -
Abdominal Aortic Aneurysm, aspects on diagnosis and treatment
(2018-11-16)Background An abdominal aortic aneurysm (AAA) is an abnormal widening of the aorta with a risk of rupture if it grows to a large diameter. Rupture ... -
Broadly protective nanoparticle-based mucosal vaccine against influenza virus infection
(2018-11-12)Influenza is one of the major viral diseases affecting humans and it is responsible for three to five million cases of severe illness and about 250.000 to 500.000 deaths each year worldwide. A vaccine against pandemic ... -
Filamin A in Cardiovascular Remodeling
(2018-11-12)Filamin A (FLNA) is a large actin-binding cytoskeletal protein that stabilizes actin networks and integrates them with cell membranes. FLNA is therefore important for cell motility and organ development. We recently ... -
Immunotherapy and immunosuppression in myeloid leukemia
(2018-11-12)Acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) are potentially life-threatening blood cancers characterized by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis ... -
Masticatory retraining effect on masseter muscle, facial morphology and alveolar bone structure in the adult rat
(2018-11-12)The aim of this series of investigations was to study the effect of masticatory muscle retraining in adult rats with an earlier reduced masticatory muscle function on the craniofacial morphology, on the internal alveolar ... -
Cardiopulmonary bypass and the kidney - studies on patients undergoing cardiac surgery
(2018-11-12)Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass (CPB), and has a major impact on morbidity, mortality and costs. The mechanism of CPB-related renal impairment is not fully ...