Sahlgrenska Academy / Sahlgrenska akademin: Recent submissions
Visas titlar 81-100 av 2677
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Help Overcoming Pain Early (HOPE) - a person-centred intervention for adolescents with chronic pain in a school setting
(2022-08-16)The overall aim of the thesis was to develop and evaluate a school health-based intervention, Help Overcoming Pain Early (HOPE) for promotion of adolescents’ ability to manage their problems with chronic pain. Study ... -
The economics of a silent pandemic - A health economic analysis of antibiotic resistance in Sweden
(2022-08-16)The overall aim of this thesis was to analyze the health economic consequences of antibiotic resistance in Sweden, and to assess the implications of methodological assumptions related to measuring health in health economic ... -
The role of sodium salicylate as a virulence inhibitor for soft tissue infections
(2022-08-16)Approximately 2% of the total population will suffer from chronic wounds during their lifetime. These wounds can last for years and are associated with considerable patient suffering and large socioeconomic costs. ... -
Peripheral airway function assessed by inert gas washout and impulse oscillometry
(2022-08-15)Small (peripheral) airways play a key role in asthma. Despite this is lung function tests for assessing small airway function not included in the routine asthma management. Undetected small airway dysfunction (SAD) may ... -
Free Fatty Acid Receptor 2 - A G protein coupled receptor with unique signaling properties in neutrophils
(2022-08-15)The overall aim of the PhD thesis was to determine the role of neutrophil pattern recognition receptors in the initiation and resolution of inflammatory processes. Neutrophil pattern recognition receptors such as the formyl ... -
Genetic determinants of lung cancer and their application toward therapeutics. The role of ZFP148 transcription factor and anaplastic lymphoma kinase (ALK) fusion proteins in non-small cell lung cancer
(2022-08-12)Lung cancer causes severe morbidity and mortality in millions of patients globally each year. Anaplastic lymphoma kinase (ALK) mutations facilitate neoplastic growth of lung cancer in adults and neuroblastoma in pediatric ... -
Approaches for the setting of occupational exposure limits(OELs) for carcinogens
(Samhällsmedicin och folkhälsa, 2022-07-05)Högberg J, Järnberg J. The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. 154. Approaches for the setting of occupational exposure limits (OELs) for carcinogens. Arbete och Hälsa ... -
Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response
(2021)Cell fate decisions during early B cell activation determine the outcome of responses to pathogens and vaccines. We examined the early B cell response to T-dependent antigen in mice by single-cell RNA sequencing. Early ... -
Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection
(2022)Following infection or immunization, memory B cells (MBCs) and long-lived plasma cells provide humoral immunity that can last for decades. Most principles of MBC biology have been determined with hapten-protein carrier ... -
Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells
(2022)B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs after infection is lacking. Here, ... -
Non-functioning pituitary adenomas and hypopituitarism - studies on morbidity and mortality
(2022-06-15)Background and aims: Hypopituitarism is most commonly caused by benign pituitary tumors, often resulting in insidious symptoms that develop over a long time. Due to either a mass effect exerted by the tumor, or due to the ... -
The transcriptomic landscape of Epstein-Barr virus associated tumors at cellular and single-molecule level
(2022-06-10)Epstein-Barr virus (EBV) was the first oncovirus found in humans. Almost all adults worldwide are asymptomatic carriers of EBV. The latent EBV-infection malignifies in approximately 200,000 individuals each year. The risk ... -
Dupuytrens sjukdom i relation till exponering för handöverförda vibrationer
(Samhällsmedicin och folkhälsa, 2022-05-30)Kunskapsöversikten syftar till att specifikt besvara frågan om risk för Dupuytrens sjukdom i relation till exponering för handöverförda vibrationer. Litteraturgenomgången följde PRISMAs systematiska metod omfattande databaserna ... -
Interprofessional Teamwork in the Emergency Department - Communicating for Patient Safety
(2022-05-27)Interprofessional teams may improve patient safety through successful communication and effective teamwork. However, ineffective teamwork occurs despite the implementation of various strategies and can compromise patient ... -
Perinatal Staphylococcus epidermidis infection and the immature brain: a neuroinflammatory link
(2022-05-27)Preterm birth and its associated complications are among the most serious global health issues that modern society faces. Due to the prolonged medical care and immature immune system, preterm infants have a higher ... -
The role of galectin-1 in type 2 diabetes. Clinical and experimental studies
(2022-05-27)Aim: The purpose of this thesis was to identify a new agent in the subcutaneous adipose tissue and assess its clinical potential in the context of type 2 diabetes. Study I: Through a combination of microdialysis and ... -
lnvestigating intestinal smooth muscle dysfunction in the 6-OHDA rat model of Parkinson's disease
(2022-05-27)The neurodegenerative progression of the nigrostriatal pathway in Parkinson’s disease (PD) entails the appearance of motor and nonmotor symptoms. Nonmotor symptoms are common, having a negative impact on the quality of ... -
Dopaminergic lnterference for Treatment of Schizophrenia and Alcohol Use Disorder - an experimental study in rats
(2022-05-27)The neurotransmitter dopamine is involved in several different physiological functions as well as pathological conditions. Two conditions that have been suggested to be related to a low dopaminergic tone in the ventral ... -
Viral proteins as serological antigens - Development and clinical applications
(2022-05-24)Serological methods are based on the detection of antibodies and antigens in mainly serum but also in other body fluids such as cerebrospinal fluid (CSF). Conventional whole virus antigens are widely used in viral serological ...