Sahlgrenska Academy / Sahlgrenska akademin: Recent submissions
Now showing items 21-40 of 2677
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Defining the pathways involved in spatial protein quality control in Saccharomyces cerevisiae
(2022-11-21)Proteins need to be folded into specific three-dimensional conformations to be functional. An extensive network of factors, the protein quality control (PQC) machinery, ensures that the cell maintains a healthy proteome ... -
Oral eflornithine treatment of late-stage human African trypanosomiasis
(2022-11-21)Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African ... -
Human stem cell-based in vitro model of cardiac hypertrophy
(2022-11-18)Cardiac hypertrophy is an important and independent risk factor for the development of cardiomyopathy that may lead to heart failure. To accelerate the development of new and improved treatment options, relevant disease ... -
A Multimodal Approach toward the Biological Categorization of Autism - Development of Theoretical Models, Classification Methods, and Biomarkers
(2022-11-18)Autism Spectrum Disorder (ASD) is an umbrella term for a group of neurodevelopmental disorders (NDD) which are behaviorally defined by the presence of difficulties with social communication, and behavioral rigidity and ... -
Aspects of decisions to withhold and withdraw life-sustaining treatment in intensive care
(2022-11-15)End-of-life decision-making is required when the patient no longer benefits from available treatment options and there is a need to redirect medical treatment goals from cure to palliative care. End-of-life decisions are ... -
Dietary quality, greenhouse gas emissions related to food consumption, and human health: A population-based cohort study in northern Sweden
(2022)The overall aim of this thesis was to assess dietary quality and dietary-related greenhouse gas emissions (GHGEs), and their association with health outcomes, in a population-based cohort in northern Sweden. Dietary data ... -
Recovery after surgically treated distal radius fracture - Aspects of evaluation and rehabilitation
(2022-11-14)BACKGROUND A distal radius fracture (DRF) is a common injury, occurring in both genders and during the entire life span, although it is most common in elderly women. An uncomplicated fracture is treated with a cast, but ... -
Effects of nonlinear noise reduction algorithms on image quality in computed tomography systems. Evaluations using human observers and methods for assessing distortion
(2022-11-10)Many conventional radiological examinations have during the past decades been replaced by examinations performed on computed tomography (CT) systems. One reason is that a CT system, in contrast to a conventional X-ray ... -
Gout - epidemiological studies on work outcomes, airborne risk factors and treatment patterns
(2022-11-10)The overall aim of the thesis was to describe the contemporary epidemiology and use of urate-lowering therapy (ULT) for gout in the Swedish region of Dalarna, to describe the impact of the disease with regard to sickness ... -
Catching broken hearts - Electrocardiography and in-hospital outcome in Takotsubo syndrome versus ST elevation myocardial infarction
(2022-11-10)BACKGROUND AND AIMS: Takotsubo syndrome (TS) and acute myocardial infarction (AMI) have similar symptoms, non-invasive test results and complications. Whereas AMI is caused by cardiac ischemia, the pathophysiology of TS ... -
On gastrointestinal viral infections
(2022-11-10)Gastrointestinal viral infections cause considerable morbidity and mortality worldwide. Many factors influencing clinical presentation, disease severity, epidemiology, and transmission are not fully understood. The aims ... -
On kidney dysfunction in advanced liver disease
(2022-11-10)Aims: The overall aim of this thesis was to characterize factors affecting kidney function in advanced liver disease as well as after liver transplantation and to further understand the complex interaction between acute ... -
Exploring mechanisms of insulin secretion regulators using C. elegans
(2022-11-09)Diabetes mellitus is a group of disorders characterized by disrupted glucose homeostasis. Diabetes is one of the most dangerous diseases worldwide since it affects currently more than 500 million people. The pathogenesis ... -
Aloe barbadensis Mill. as a therapeutic option for irritable bowel syndrome – properties, bioactivity and mode of action
(2022-11-08)Irritable bowel syndrome (IBS) is a chronic and prevalent functional gastrointestinal disorder, with an incompletely understood pathophysiology. Because of the disease complexity and heterogeneity, the currently available ... -
lntramuscular pressure in the lower leg - Studies on chronic exertional compartment syndrome and effects of external compression
(2022-11-04)This thesis on intramuscular pressure (IMP) in the lower leg is concerned with two topics. The first of these is external compression; more specifically, the effect of compression stockings (CS). There are conflicting data ... -
Risk Assessments in Forensic Psychiatry: Consequences and Experiences for Patients and Nurses
(2022-11-02)In forensic psychiatry, risk assessment of future violence poses a great challenge to mental health care professionals. Forensic psychiatric patients are particularly vulnerable due to their complex mental health needs in ... -
Cardiopulmonary bypass: Clinical studies in cardiac surgery patients
(2022-11-01)BACKGROUND: Cardiopulmonary bypass (CPB) is necessary to facilitate most cardiac operations. Although the vast majority of patients tolerate CPB physiology in conjunction with cardiac surgery well, there is risks of adverse ... -
Heart failure with reduced ejection fraction of ischaemic and non-ischaemic aetiology – Clinical characteristics, prognosis and factors associated with outcome
(2022-10-28)BACKGROUND: Ischaemic heart disease (IHD) is common in heart failure (HF) and is often considered to infer a worse prognosis. Following treatment improvements and the increased survival in both IHD and HF, patients are ... -
Coagulation in paediatric cardiac surgery
(2022-10-28)Background: Surgical correction of congenital heart defects has a profound effect on the coagulation of the patients during and immediately after surgery. The aim of this thesis was to increase the knowledge of this effect, ... -
Postoperative infections and bladder distension following hip fracture surgery Findings from implementing patient safety innovations
(2022-10-26)Adverse events such as hospital-acquired infections and bladder distension are largely preventable if evidence-based recommendations are adhered to. The overall aim of this thesis was to promote healthcare workers’, ...