Sahlgrenska Academy / Sahlgrenska akademin: Recent submissions
Now showing items 681-700 of 2677
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Understanding the regulatory requirements for gut IgA B cell responses and their potential role in mucosal vaccine development
(2018-05-28)It is important to understand gut B cell differentiation, from the activation of cells at inductive lymphoid sites to the formation of gut plasma and memory B cell, to be able to develop efficient oral vaccines but the ... -
Evaluating benefits and harms of screening - the streetlight effect?
(2018-05-25)The general aim of this thesis was to explore how the benefits and harms of screening for a potentially life-threatening disease can be evaluated. Papers I and II are a Cochrane Systematic Review on screening for malignant ... -
Nutritional aspects of advanced Head and Neck Cancer and impact of different factors in Head and Neck Cancer of Unknown Primary
(2018-05-25)Background/Aims: Swallowing problems and malnutrition are common in advanced head and neck (HN) cancer. The aim of paper I was to study whether percutaneous endoscopic gastrostomy (PEG) affected the long-term swallowing ... -
Hearing-related symptoms among women - Occurrence and risk in relation to occupational noise and stressful working conditions
(2018-05-24)A considerable amount of research has been devoted to the risk of noise-induced hearing loss among industry workers – the majority of whom are men. Much less research has been done in female-dominated human service ... -
Stratification and model-based analysis of patients with Irritable Bowel Syndrome using advanced biostatistics and medical data mining techniques
(2018-05-24)ABSTRACT Irritable Bowel Syndrome (IBS) is characterized by symptoms that are dominated by abdominal pain and abnormal bowel habits, as defined by the Rome criteria. The complexity of the disorder is exemplified by the ... -
Investigating antenatal care services, intimate partner violence and non-psychotic mental health disorders among postpartum women in Rwanda
(2018-05-22)Although maternal mortality has decreased in the past years and more women visit antenatal care (ANC) services during pregnancy in Rwanda, initiation and completion of the recommended number of visits remain a problem. It ... -
Left-sided obstructive cardiac lesions in the fetus and the neonate
(2018-05-21)ABSTRACT Introduction Hypoplastic left heart syndrome (HLHS) is a severe cardiac malformation, fatal in the neonatal period in the absence of immediate care. Palliative surgery for HLHS has been available in Sweden since ... -
Effects of antioxidant supplementation on cancer progression
(2018-05-18)Popular wisdom holds that antioxidants protect against cancer because they neutralize reactive oxygen species (ROS) and other free radicals which can otherwise cause cancer by damaging DNA. This has been the rationale ... -
Addison's Disease and Type 1 Diabetes Mellitus
(2018-05-18)Background: Patients with type 1 diabetes (T1DM) and patients with Addison’s disease (AD) need life-long replacement therapy with insulin and glucocorticoids (GCs), respectively. Both groups have reduced life-expectancy. ... -
Esophagitis: Aspects on bacteriology, pathophysiology and symptomatology
(2018-05-18)Gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are the two most common diseases causing inflammation of the esophagus, namely, esophagitis. GERD and EoE are different in many aspects, but ... -
Ovarian stimulation for IVF-a balance between efficacy and safety
(2018-05-18)Background: To increase the chance of a live birth after in vitro fertilization (IVF) a controlled ovarian hormonal hyperstimulation (COH) is used to collect a certain number of oocytes for fertilization. COH is a potent ... -
Muscle strength and resistance exercise in women with fibromyalgia - a person-centered approach
(2018-05-15)Fibromyalgia (FM) is characterized by generalized pain and associated with impaired physical capacity and activity limitations. Low-intensity exercise has been shown to be a safe way to exercise without risking an increase ... -
The clinical utility of patient-reported outcome measures in total hip replacement and lumbar spine surgery
(2018-05-15)Background: Beginning in the late 1990s, the Swedish Hip Arthroplasty Register (SHAR) and the Swespine have successfully implemented programs to collect patient-reported outcomes measures (PROMs). The use of PROMs has ... -
Origins of thyroid progenitors and tumor-initiating cells
(2018-05-14)The thyroid gland located in the anterior neck consists of two main cell types. First, the follicular cells that form the functional units, the follicles, in which thyroid hormones are produced and stored before release ... -
Dendritic cells and B cells in effector T cells decisions - promotion of antibody induction in lymphoid tissues or gut homing
(2018-05-14)Abstract CD4+ T cells are principal cells of the adaptive immune system, equipped with the ability to boost innate immune cells and aid B cells in the germinal centers. Every T cell clone carries a variable and unique T ... -
Renal function in cardiac surgery - Clinical and experimental studies
(2018-05-14)Background: Impaired renal function (measured as glomerular filtration rate (GFR)) is a well-known problem after heart surgery and heart transplantation (HTx), affecting both short-term and long-term survival. The reason ... -
Function of Surface-Associated Protein and DNA on Extracellular Vesicles
(2018-05-09)Extracellular vesicles (EVs), including exosomes, are nano-sized, lipid bilayer enclosed vesicles that are released into the extracellular environment from by almost all cells. EVs contain biomolecules, such as proteins, ... -
Hypospadias surgery - long-term outcome focusing on adolescence
(2018-05-09)Hypospadias is a malformation that affects 1/125 born boys in Sweden. 1/10 with hypospadias are born with the most severe form; proximal hypospadias. The treatment, which is surgical, is performed during the first years ... -
Contraception and unplanned pregnancies
(2018-05-09)Aims: The overall aim of this thesis was to describe the relationship between contraceptive use, abortion, birth and fertility rates among women in different age groups in Sweden and the other Nordic countries. Material ... -
Ex Vivo Lung Perfusion - experimental and clinical studies
(2018-05-07)Background: Ex vivo lung perfusion (EVLP) has since its introduction in clinical practice experienced a rapid expansion and made more organs available for transplantation. Different protocols and strategies have been ...