Institute of Biomedicine / Institutionen för biomedicin: Recent submissions
Now showing items 221-240 of 328
-
Interplay between Pathogenic and Immune Regulatory Mechanisms in G-alpha-i2 deficient colitis
(2011-12-20)The two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC) are gastrointestinal disorders characterized by chronic and relapsing inflammation. Mice deficient in the inhibitory ... -
Virulence factors and clonal relatedness of enterotoxigenic Escherichia coli (ETEC) isolated from children with diarrhoea in Bolivia
(2011-11-25)Enterotoxigenic Escherichia coli (ETEC) is one of the major causes of diarrhoea in children under five years of age in developing countries and in travellers to these settings. To cause disease, ETEC must be able to colonize ... -
On the outcome of antiviral therapy for hepatitis C virus genotype 2 or 3 infection
(2011-11-09)Abstract Approximately 80% of patients infected with HCV genotypes 2 or 3 achieve a sustained virological response (SVR), following 24 weeks of therapy with ribavirin and pegylated interferon (peg-IFN), but in light of ... -
Chemical basis of ABO subgroups
(2011-10-28)Despite the ABO histo-blood group system being the most biologically significant in humans the chemical structures that define its various phenotypes still remain largely unresolved. Like all blood group systems there ... -
Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms
(2011-05-27)Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown ... -
On the stimulatory effect of microglial cells on angiogenesis
(2011-05-26)ABSTRACT Angiogenesis, the process by which new vessels sprout from pre-existing vessels, is fundamental to development, tissue growth and repair. The main aim of this thesis was to investigate the role of microglia on ... -
Embryonic ecdysone-induced gene expression and progression of organ morphogenesis
(2011-05-26)The formation of an epithelial organ requires a set of organ-specific gene programs that instruct parallel and successive developmental events. Still, it is unclear what are the core regulatory programs and how such programs ... -
Intracellular regulation of TLR signaling Basic mechanisms and importance in intestinal inflammation
(2011-04-21)Toll-like receptors (TLRs) recognize conserved structures on/in microorganisms. The intracellular signalling pathways of TLRs are shared with IL-1R and IL-18R and their activation leads to transcription of proinflammato ... -
Function of natural killer cells in Helicobacter pylori infection and gastric cancer
(2011-02-22)Helicobacter pylori infection is one of the most wide-spread infections in the world and causes a chronic inflammation in the gastrointestinal mucosa characterised by increased production of IFN-γ and is associated with ... -
From 1p3 to PI3K - Studies of neuroblastoma
(2011-01-19)Neuroblastoma (NB) is a tumor of the sympathetic nervous system and is the most common extra-cranial tumor of childhood, accounting for 7% of all pediatric malignancies. Despite recent advances in therapeutics, outcome is ... -
Geographic and genetic diversity of hepatitis B
(2011-01-04)Hepatitis B Virus (HBV) infection is a global health problem and may lead to chronic hepatitis, liver cirrhosis and hepatocellular cancer. The ability of HBV to adapt to the host environment by genetic variation has lead ... -
Evolution of protein and non-coding RNA genes studied with comparative genomics
(2010-12-16)The identification of protein and non-coding RNA (ncRNA) genes is one important step in the analysis of a genome. This thesis focuses on the identification and analysis of proteins and ncRNAs homologues by exploiting a ... -
Molecular mechanisms of embryonic stem cell pluripotency: transcription, telomere maintenance and proliferation
(2010-11-19)Somatic cell nuclear transfer and generation of induced pluripotent stem cells provide potential routes towards generation of patient specific embryonic stem (ES) cells. These procedures require induction of Oct4 gene ... -
Bacterial colonization of the neonatal bowel and ileal pouch with focus on E. coli
(2010-11-19)The colonic microbiota is a source of inflammatogenic and potentially pathogenic bacteria, but also a source of immune maturation signals to the infant. Here, we have investigated the normal colonic microbiota, with focus ... -
LEUKOCYTE RECRUITMENT TO HUMAN GASTROINTESTINAL TISSUES - STUDIES IN H. PYLORI-INDUCED GASTRITIS AND COLON ADENOCARCINOMAS
(2010-11-19)Chronic inflammation is a major pathological basis for tumor development and two examples are H. pylori infection of the stomach mucosa and inflammatory bowel disease, which are strongly associated with gastric and colon ... -
TGF-beta signaling in cancer
(2010-11-19)Transforming Growth Factor beta (TGF-beta) is a cytokine regulating a wide range of cellular processes such as proliferation, differentiation, and migration. At the early stages of cancer development TGF-beta functions as ... -
Mucosal adjuvants and their mode of action in the female genital tract
(2010-10-18)Sexually transmitted infections (STIs) cause a socioeconomic burden, morbidity and even mortality in a large part of the human population all over the world today. One of the most common genital ulcerative diseases is ... -
The immunomodulatory function of staphylococcal superantigen on oral tolerance
(2010-10-08)Exposure to soluble proteins via the gut gives rise to systemic tolerance, a phenomenon called oral tolerance. Failure of oral tolerance results in allergy, a disease that has increased during the last decades in Western ... -
Transcriptional profiling of human embryonic stem cells and their functional derivatives
(2010-10-07)Human embryonic stem cells (hESCs) represent populations of pluripotent, undifferentiated cells with unlimited replication capacity, and with the ability to differentiate into any functional cell type in the human body. ... -
Identification of stem cell factors - Novel protein-protein interactions and their functions
(2010-09-10)Embryonic stem (ES) cells provide an unlimited source of cells potentially useful for regenerative medicine, however, prior to clinical implementation, additional basic research is needed. This thesis is focused upon ...