Institute of Biomedicine / Institutionen för biomedicin: Recent submissions
Now showing items 281-300 of 328
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FET proteins in cancer and development
(2009-02-13)Chromosomal translocations leading to rearrangements of FET family genes (FUS, EWSR1 and TAF15) are found in numerous human cancers. These genetic alterations result in the formation of fusion oncogenes that express potent ... -
DNA damage affecting thyroidal iodide transport: an explanation to thyroid stunning
(2008-11-24)131I is widely used clinically in the treatment of Graves´ disease and differentiated thyroid cancer. However, cellular and molecular effects of 131I irradiation in relation to absorbed dose are poorly documented. For ... -
The contribution of proteins and lipids to COPI vesicle formation and consumption
(2008-11-18)In the secretory pathway, movement of proteins between compartments occurs through small (50-100 nm) vesicles. The coat of COPI vesicles is composed the small GTPase ARF1 and the large coatomer complex. In the secretory ... -
Developmental origin and molecular regulation of vascular smooth muscle cells
(2008-11-18)Several pathologies of the vascular system have been suggested to be dependent on the smooth muscle cells (SMCs) that build up the vessel wall. Aortic SMCs have been proposed to derive from lateral plate mesoderm. It has ... -
Vaginal commensal bacteria. Interactions with cervix epithelial and monocytic cells and influence on cytokines and secretory leukocyte protease inhibitor, SLPI
(2008-11-14)Vaginal commensal bacteria Interactions with cervix epithelial and monocytic cells and influence on cytokines and secretory leukocyte protease inhibitor, SLPI Louise Strömbeck Department of Infectious Medicine, ... -
Transcriptional regulation of thyroid development possible interplay of endoderm- and mesoderm-derived morphogenetic signals
(2008-10-14)Congenital hypothyroidism (CH) affects 1 in 3000 children and is the major cause of treatable mental retardation. Most cases are due to malformations of the gland, collectively named thyroid dysgenesis. The disease results ... -
Regulation of the Epstein-Barr virus C promoter by the OriP-EBNA1 complex
(2008-10-13)Epstein-Barr Virus (EBV) is an exclusively human, lymphotropic herpes virus that infects more than 90% of the population worldwide. Primary infection usually occurs during the early years of life and does not result in ... -
Methods for evaluation of early bone healing at titanium implants
(2008-10-03)Titanium has for a long time been the implant material of choice when in need for abilities as strength, biocompatibility and stability. Although numbers of studies have been made, little is known about the early events ... -
An animal model of sport related concussive brain injury
(2008-10-02)A new animal model for concussion of the type seen in professional football was developed, since current animal models did not simulate these conditions. The model is characterized by a high velocity-low mass impact to the ... -
Transcriptional Regulation of the Platelet-Derived Growth Factor B-receptor by p53 Family Members
(2008-09-29)Aims: The platelet-derived growth factor β-receptor (PDGFRB) is critically involved in embryonic development and has a role in many diseases. In cells, signaling through PDGFRB affects growth, migration and death. The role ... -
Autoproteolysis accelerated by conformational strain - a novel biochemical mechanism
(2008-09-08)Natural fragmentation of polypeptide chains by autoproteolysis occurs in a number of protein families. It is a vital step in the maturation of several enzymes and in the formation of membrane-associated mucins that constitute ... -
Recruitment, Differentiation, and Function of monocytes during Salmonella infection
(2008-05-30)Monocytes are a heterogeneous population in the blood with an enormous plasticity whose fate and functions are dictated by the microenvironment. They are phenotypically and functionally related to neutrophils and dendritic ... -
Molecular mechanisms for lineage-restricted differentiation of adult neural progenitors
(2008-05-21)Aims: In the central nervous system of several species, including humans, neurogenesis per¬sists even in the adult life in discrete neurogenic regions of the brain. Adult neural stem cells derived from these neurogenic ... -
Hypoxia-inducible factors (HIFs) and biological responses, in hypoxia, inflammation and embryonic vascular development.
(2008-04-21)ABSTRACT Low oxygen tension (hypoxia) is a major inducer of neovascularisation and evidence emerging has indicated that oxygen tension and hypoxia-inducible factors (HIFs), a family of oxygen-regulated heterodimeric ... -
Directing stem cells and progenitors towards neuronal differentiation - implications for experimental therapies for Parkinson's disease
(2008-04-09)The insight that stem- and progenitor-cells contribute to replacement of nerve cells in the adult central nervous system is the basis of modern therapies for structural brain repair. Their goal is to protect, support and ... -
Immunofluorescence Investigation on Neuroendocrine Secretory Protein 55 (NESP55) in Nervous Tissues
(2008-03-31)The chromogranin family is a group of acidic, soluble, and heat-stable proteins widespread in various neuronal, neuroendocrine and endocrine tissues, where they are subcellullarly located in the secretory granules, ... -
Regulation and expression of Epstein-Barr virus nuclear antigen 1 in transplant patients and cell culture
(2008-03-27)Epstein-Barr virus (EBV) is a human herpes virus that infects over 90% of the world population. Once infection has occurred, the virus persists for life in its host, mainly in an asymptomatic, latent stage with only a few ... -
Studies on the Expression and Regulation of Enterotoxins and Colonization Factors in Enterotoxigenic Escherichia coli (ETEC)
(2008-02-28)Enterotoxigenic Escherichia coli (ETEC) is one of the most common causes of acute watery diarrhoea in developing countries, particularly among local children less than five years and is also the most common cause of diarrhoea ... -
Genetic Studies of Psoriasis and Psoriatic Arthritis
(2008-02-08)Psoriasis and psoriatic arthritis are common chronic immune-mediated diseases of the skin and joints. Psoriasis affects approximately 2-3 % of the Caucasian population and about 30 % of all psoriasis patients develop ... -
The Germinal Centre reaction - Genetic and proteomic analysis of factors important for survival and growth of B lymphocytes
(2008-02-01)During an immune response the B lymphocytes main function is to produce antibodies in the specific defence against the pathogen. When naïve B lymphocytes become activated by binding of an antigen, the cells differentiate ...