Institute of Biomedicine / Institutionen för biomedicin: Recent submissions
Visas titlar 261-280 av 328
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Acute and chronic peritonitis in peritoneal dialysis: neurogenic inflammation and citrate treatment
(2009-10-06)The prevalent problems associated with peritoneal dialysis (PD) are ultrafiltration failure and peritonitis. During PD the patient is sustained on a state of intraperitoneal inflammation, which over time impairs structure, ... -
Regulatory CD4+FOXP3+ T cells in Helicobacter pylori-induced disease
(2009-10-01)Helicobacter pylori colonize the gastric or duodenal mucosa of approximately half of the worlds’ population. Although most individuals are asymptomatic, H. pylori infection cause peptic ulcers or gastric cancer in 10-15 % ... -
The Neuroblastoma Genome and Epigenome - Patient Stratification and Identification of Candidate Genes
(2009-09-30)Neuroblastoma (NB) is a tumor of the sympathetic nervous system, and the most common extracranial tumor of childhood. The prognosis for high-stage NBs is still poor, with survival rates of about 35%. Side-effects of treatment ... -
Intestinal IgA synthesis: Localization and requirements for IgA class switch recombination
(2009-09-03)Production of IgA at mucosal surfaces is one of the most striking features of the mucosal immune system. Despite that IgA was first discovered in the 1950’s and secretory IgA described in gut secretions and breast milk ... -
Commensal microbes, immune reactivity and childhood inflammatory bowel disease
(2009-06-29)Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal inflammation of unknown etiology, but immune activation by the commensal microbiota probably plays a major role. The two major categories ... -
Studies on bacterial transmission pathways in a high endemic area, with a focus on Helicobacter pylori
(2009-06-29)Even though half of the world’s population is infected with Helicobacter pylori, which causes gastritis, peptic ulcer and gastric cancer, the transmission routes of these bacteria remain unknown despite extensive epidemiological ... -
Vaccination against cholera and ETEC diarrhea and interventions to improve vaccine immune responses.
(2009-06-10)Vaccination against cholera and ETEC diarrhea and interventions to improve vaccine immune responses Abstract Vibrio cholerae O1 and enterotoxigenic Escherichia coli (ETEC) together account for the majority of bacterial ... -
Cerebral complications in infective endocarditis
(2009-05-27)Infective endocarditis (IE) is a life-threatening disease. Cerebral embolization complicates the course in 10-40% of IE episodes. Aims of study were to investigate the frequency of cerebrovascular complications (CVC) in ... -
The MUC2 mucin -A network in the intestinal protective mucus
(2009-05-26)The intestine is covered by mucus that is the first line of defence of the epithelium. The main structural component of the intestinal mucus is the MUC2 mucin. This is a large glycoprotein with two long and heavily ... -
Regulation of innate and adaptive immune responses by Gram-positive and Gram-negative bacteria
(2009-05-20)Bacteria are classified as Gram-positive or Gram-negative, depending on their cell wall structure. The role of the bacterial cell wall in immune regulation is the focus of the current work. Most Gram-positive bacteria ... -
Norovirus, causative agent of winter vomiting disease, exploits several histo-blood group glycans for adhesion
(2009-05-20)Norovirus is recognized as the major cause of outbreaks of gastroenteritis world-wide, yet no vaccines or drugs are available for prevention or treatment of the virus infection. Challenge studies and binding studies using ... -
The female genital tract microbiota: composition, relation to innate immune factors, and effects of contraceptives
(2009-05-13)Abnormal vaginal microbiota, as in bacterial vaginosis (BV), is associated with increased risk of obstetrical and gynaecologic complications and acquisition of sexually transmitted diseases. However, very little is known ... -
Cartilage Tissue Engineering; the search for chondrogenic progenitor cells and associated signalling pathways
(2009-05-12)The socioeconomic cost of articular cartilage related diseases in the Western world is very high. The suffering of the individual patient is even more problematic. Different methods are used today to treat this large, ... -
A mouse model for direct evaluation of cholera vaccines
(2009-04-23)Cholera continues to be an important cause of morbidity and mortality in large parts of the developing world and is a significant negative factor for economic development. Vibrio cholerae bacteria of the O1 or O139 serogroup ... -
Studies of Carbohydrate-Binding Proteins from Enterotoxigenic Escherichia coli
(2009-04-06)Knowledge about the carbohydrate binding specificity of pathogens can give an increased understanding of their virulence strategies, and is also of importance for the development of anti-adhesive therapies and vaccines. ... -
Regulation of gene expression in the vascular wall
(2009-03-31)Blood vessel growth and function are closely related to a number of pathological conditions, including tumor angiogenesis, wound healing and atherosclerosis. Smooth muscle cells (SMC) and endothelial cells (EC), the two ... -
New Roles of Filamins in Cell Signaling, Transcription and Organ Development
(2009-03-12)Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell ... -
Genetic linkage and association studies in celiac disease: discoveries from whole genome analysis
(2009-03-06)Celiac Disease (CD) or Gluten Sensitive Enteropathy (GSE) is a life-long disorder. It is characterized by inflammation in the small intestine of genetically predisposed individuals caused by inappropriate immune response ... -
Molecular regulation of epithelial tube size
(2009-02-27)In nature, epithelial tubes are vital structures in organ design and are required for transport of gases and liquids in organs, such as the vascular system, the vertebrate lung and the kidneys. The tubular epithelium is ... -
Epidemiological and immunological studies of environmental mycobacteria - with focus on Mycobacterium abscessus
(2009-02-27)Mycobacterium avium, M. abscessus and M. gordonae are three mycobacterial species that are ubiquitous in the environment. M. gordonae is non-pathogenic, while M. avium and M. abscessus can cause skin abscesses and airway ...