Institute of Biomedicine / Institutionen för biomedicin: Recent submissions
Visas titlar 301-320 av 328
-
The assembly of cytosolic lipid droplets and its effect on insulin sensitivity
(2007-12-21)Accumulation of neutral lipids, in particular triglycerides, in non-adipocytes is highly related to the development of insulin resistance and its consequences, type-2 diabetes and cardiovascular diseases. The accumulation ... -
Dendritic cell maturation and death during Salmonella infection. Role of pro-inflammatory cytokines and MyD88
(2007-12-21)The costimulatory molecules CD80 and CD86 are required for the ability of dendritic cells (DC) to induce both tolerance and immunity. This thesis investigates the control of CD80/CD86 upregulation in vivo on DC during ... -
Regulation of the Epstein-Barr Virus Latent Membrane Protein 1 Expression
(2007-12-21)Epstein-Barr virus (EBV) is a probably the most effective and successful human virus, infecting more than 90% of the world’s adult population. As with the other members of the herpesvirus family, EBV establishes latent ... -
Functional characterization of the secretory pathway and the role of COPI vesicles
(2007-12-18)In the secretory pathway, proteins synthesized in the endoplasmatic reticulum move through the Golgi apparatus in a cis-to-trans direction and then sorts into different types of vesicles at the trans-Golgi network. How ... -
Characteristics and Consequences of Thymic Involution in Inflammatory Bowel Disease. Experimental studies in Gαi2-deficient and DSS-induced Colitis as well as in IBD patients
(2007-12-06)Characteristics and Consequences of Thymic Involution in Inflammatory Bowel Disease. Experimental studies in Gαi2-deficient and DSS-induced Colitis as well as in IBD patients Kristina Elgbratt Department of Microbiology ... -
Evolution of Transmembrane and Gel-forming Mucins Studied with Bioinformatic Methods
(2007-11-13)All mucosal membranes of the body are covered by mucus, largely made up of the family of large glycoproteins called mucins. These are instrumental for the protection of the underlying epithelia and involved in the pathogenesis ... -
Genetic re-targeting and de-targeting of adenovirus type 5 in order to create vectors for gene therapy
(2007-11-12)Gene therapy has been considered to be a revolutionary development in medicine, whereby the cause and not the symptoms of the disease would be treated. These expectations have as yet not been realized, mainly due to lack ... -
Dynamic changes in T cell compartments and new approaches in evaluating DSS induced and Gai2 deficient colitis
(2007-11-06)The overall aim of this thesis was to increase the understanding of the immunopathology of Inflammatory Bowel Disease (IBD). The first aim was to elucidate how the thymus and the gut epithelium were affected by colitis. ... -
Application of imaging TOF-SIMS in cell and tissue research
(2007-10-19)This thesis is aimed at extending the use of TOF-SIMS (time of flight secondary ion mass spectrometry) as an analytical tool in cell and tissue research. TOF-SIMS is a relatively new method that allows analysis of the ... -
Granulocyte activation by danger signals and blocking of receptor responses
(2007-10-09)Granulocytes are the most abundant cells in the peripherial blood. They serve to eliminate invading microbes and parasites and release anti-microbial agents. In the event of injury, granulocytes are recruited to damaged ... -
Mechanisms of dendritic cell maturation induced by intracellular bacteria infection
(2007-10-02)Dendritic cells (DCs) are essential for the development of an immune response against pathogens such as Listeria monocytogenes and Salmonella typhimurium. This is mostly because of their unique capacity to stimulate naïve ... -
Genetics and functions of innate-like lymphocyte subsets
(2007-09-21)The immune system contains three different branches: innate immunity, adaptive immunity and innate-like lymphocytes that share properties both with the innate and adaptive immune cells. The innate-like lymphocytes have the ... -
Foxi1, an important gene for hearing, kidney function and male fertility
(2007-08-27)Aim: In this study we focused on the biological importance of the forkhead transcription factor Foxi1. The overall aim was to elucidate the functional role of Foxi1 in the inner ear, kidney and epididymis. When mice ... -
Development of novel immunization approaches to generate immunity in the female genital tract with special reference to genital herpes
(2007-08-22)Development of mucosal vaccines for inducing immunity in the female reproductive tract would have profound implications for the prevention of sexually transmitted diseases. Despite numerous efforts, no such vaccines are ... -
Anti-herpes simplex virus activities of sulfomannan oligosaccharide PI-88 and disulfated cyclitols
(2007-06-20)Herpes simplex virus (HSV) initiates invasion of human cells by binding to the cell surface heparan sulfate (HS) glycosaminoglycan chains. This step is mediated by the viral envelope glycoproteins gC and/or gB. Sulfated ... -
Characterization of non-coding mRNA in Epstein-Barr virus
(2007-05-25)Epstein-Barr virus (EBV) is a human gammaherpesvirus that infects lymphoid and epithelial cells. The virus is the causative agent of infectious mononucleosis, a self-limiting lymphoproliferative disease, and it is additionally ... -
Antiretroviral treatment of HIV-1 in the central nervous system
(2007-05-24)HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will ... -
Antibiotic Resistance and Fitness of Escherichia coli in the Infantile Commensal Microbiota
(2007-05-14)Microbial resistance to antibiotics is a growing problem worldwide. Resistance develops not only in microbes which are the targets of the antibiotic treatment, but also in those belonging to the normal microbiota of the ... -
Evolution of human alpha-herpesviruses
(2007-04-24)Herpesviridae is a large virus family with more than 100 members, which are highly disseminated among animals. Three sub-families have been classified; alpha-herpesviruses, beta-herpesviruses and gamma-herpesviruses. Eight ... -
Regulation of mucosal inflammation by fibroblasts
(2007-04-20)ABSTRACT Acute inflammation in the bowel, a response of the immune system to infections or trauma, is probably a frequent but localized event, but when the barrier is repaired and the infection cleared, it is quickly ...