Institute of Biomedicine / Institutionen för biomedicin: Recent submissions
Now showing items 141-160 of 328
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Mediator and cell cycle regulation
(2015-11-04)The multiprotein Mediator complex is an evolutionarily conserved coregulator of eukaryotic transcription. Mediator functions as a bridge between gene-specific transcription factors and the RNA polymerase II transcription ... -
Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus
(2015-10-23)Obesity is a global health problem and affects women of reproductive age. During pregnancy, obesity increases the risk for gestational diabetes mellitus (GDM), in turn predisposing for type 2 diabetes (T2D). Not only the ... -
Genetic diversity of the heat labile (LT) and heat stable (ST) toxins of human enterotoxigenic Escherichia coli (ETEC): New insights into polymorphism, regulation, and gene transcription
(2015-09-16)Infection with enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in children in developing countries and travelers to endemic regions. ETEC is a diverse pathogen, with a wide range of virulence factors ... -
The clinical importance of non-HLA specific antibodies in kidney transplantation
(2015-06-16)The clinical significance of human leukocyte antigen (HLA) antibodies (Abs) for hyperacute, acute and chronic antibody-mediated rejection (AMR) of kidney allografts has been clearly demonstrated. AMR occurs in the absence ... -
General awareness of HIV, tuberculosis co-infections and the quality of life among patients with HIV in Xinjiang, in western China
(2015-05-22)Mycobacterium tuberculosis (TB) and human immune deficiency virus (HIV) infections are major public health problems, particularly in low and middle-income countries. China has the second-highest number of TB cases per year ... -
Immunization approaches and molecular signatures for mucosal immunity to primary and recurrent genital herpes
(2015-05-21)Genital herpes is most commonly caused by herpes simplex virus type 2 (HSV-2), and is a prevalent sexually transmitted infection worldwide. Despite numerous efforts, there is currently no licensed vaccine against the ... -
On the role of innate cell interactions in inflammation and leukemia
(2015-05-18)Inflammatory cells of the innate immune system launch rapid and powerful effector responses in the combat against infectious pathogens. However, these inflammatory mediators may cause excessive damage to the host and, ... -
On HIV-1 latency and viral reservoirs
(2015-05-11)HIV-1 establishes a latent infection that is inaccessible to treatment in cellular and anatomical reservoirs. This thesis concerns several problematic issues of HIV-1 persistence, including ways to measure and monitor ... -
Norovirus Tracing in Environmental and Outbreak Settings - Experiences of waterborne, foodborne and nosocomial transmission
(2015-05-04)Noroviruses (NoV), a major cause of acute gastroenteritis in hospital settings, also occur as sporadic infections or periodic non-seasonal community outbreaks. Human NoV replicates to high concentration in the intestinal ... -
Functional and Phenotypic Studies of Eosinophilic Granulocytes in Patients with Eosinophilic Esophagitis
(2015-04-27)Eosinophilic Esophagitis (EoE) is a chronic inflammatory disorder of unknown etiology, in which the esophagus is infiltrated by eosinophils and T cells. Topical corticosteroids are one of the treatment options for patients ... -
Studies on glycosphingolipids in infection, immunity and differentiation
(2015-04-17)Cell surface glycoconjugates play a role in many biological processes such as responses to microbial infections, cell-cell interactions, differentiation, and inflammatory responses. The present work is focused on structural ... -
User-centered design of ERCP teleguidance
(2015)We are designing a novel telemedicine service, where an experienced endoscopist at a central site can guide endoscopists at remote hospitals during procedures (mainly ERCP). This can be done simultaneously to several ... -
Impact of Host Genetic Variants on Natural History and Treatment of Hepatitis C Virus Infection
(2015-01-30)Chronic hepatitis C Virus (HCV) infection causes liver disease and may progress to severe fibrosis, cirrhosis, and hepatocellular carcinoma. This thesis aimed to evaluate the impact of host genetics, i.e. genetic variants ... -
Hereditary Colorectal Cancer; Identification, Characterization and Classification of Mutations
(2015-01-07)Hereditary factors are thought to play are role in 20-30% of all colorectal cancers Around 6% are found as high penetrant disease-causing mutations in genes correlated to hereditary polyposis or hereditary non-polyposis ... -
On community acquired infections requiring intensive care
(2015-01-07)Acute bacterial meningitis (ABM), influenza, and necrotizing soft-tissue infections (NSTIs) are diseases that in a short period of time can progress to become life threatening. Individuals with severe forms of these ... -
On morbidity and mortality in novovirus infection
(2014-12-02)Norovirus causes epidemic gastroenteritis. The extent of excess mortality related to norovirus infections is not established and factors that influence the duration of viral shedding have not been determined. The aims of ... -
Study of the colonic mucus layer by mass spectrometry
(2014-12-02)The mucus covering our internal mucosal surfaces is a part of the innate immune system, and the first line of defense against microbial challenges. The need of an efficient defense system is especially important in the ... -
Mucus associated proteins and their functional role in the distal intestine
(2014-11-28)The mammalian intestine, especially the large intestine, harbors complex societies of beneficial bacteria coexisting with the host. This is a mutualistic relationship, where the host provides nutrients and a favorable ... -
Biological functions of G-quadruplexes
(2014-11-24)G-quadruplexes are four-stranded nucleic acid structures formed by quartets of Hoogsteen base paired guanine bases. They are known to form at telomeres and other genomic sites, and are predicted to do so at a large proportion ... -
Progesterone's effect on factors that influence gamete transport in the fallopian tube
(2014-11-21)ABSTRACT The fallopian tube plays an important role for successful female reproduction as it transport gametes to the fertilization site, nourish the developing embryo and transport it to the uterus at the suitable time ...