Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi: Recent submissions
Visas titlar 221-240 av 437
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Epidemiological studies of sexuality in old age
(2015-01-22)ABSTRACT Aim: The overall aim of this thesis was to improve knowledge about sexuality in an older population and to try to understand the context and factors, affecting sexuality in general population. It is based on three ... -
Genetic studies of autism and autistic-like traits
(2015-01-09)Autism spectrum disorder (ASD) is characterized by impairment in social interaction, language impairment and repetitive behavior with varying degrees of severity. ASD represents the lower end on a continuously distributed ... -
Growth pattern and nutritional intake as predictors for retinopathy of prematurity
(2015-01-07)Background: Retinopathy of prematurity (ROP) is a sight-threatening disease that affects extremely preterm and very preterm infants. Approximately 5–10% of infants screened for ROP go on to develop severe ROP that requires ... -
Population Pharmacokinetic-Pharmacodynamic Modelling of Antimalarial Treatment
(2014-11-28)Malaria is one of the most important tropical diseases, with hundreds of millions of cases every year. The current recommended treatment is an artemisinin based combination therapy (ACT), which has shown good efficacy. ... -
Longterm prognosis of multiple sclerosis in untreated patients and in patients treated with first generation immunmodulators
(2014-11-24)The course of multiple sclerosis (MS) is extremely variable. A limited number of demographic and clinical variables at MS onset were described to predict time to the onset of irreversible disability. However, there is no ... -
Long-term post-stroke outcome - the Sahlgrenska Academy Study on Ischemic Stroke
(2014-11-21)Independent studies report that stroke incidence in younger ages is increasing. Consequences after stroke include disability, cognitive dysfunction and the risk of stroke recurrence and coronary events. There are still ... -
Central and Systemic Inflammation in Developmental Brain Injury
(2014-11-21)Brain injury occurring during the perinatal period is an important cause of mortality and morbidity with potentially life long consequences. Both preterm and asphyxiated full term infants are at high risk of developing ... -
The role of estrogen and superoxide dismutase in cataractogenesis
(2014-11-03)Cataract is an opacification of the eye lens, constituting the major cause of blindness globally. Oxidative stress is a key factor in the formation of cataract and female gender is a known risk factor for age-related ... -
Autism Spectrum Disorders in preschool children: cognitive aspects and interventions
(2014-10-30)Aim: The overarching aims of this thesis were to (a) gain further insight into the developmental/cognitive aspects of autism spectrum disorders (ASD) in young children, and (b) assess outcome after interventions of varying ... -
Force, falls and fear of falls in myotonic dystrophy type 1. Cross-sectional and longitudinal studies
(2014-09-26)ABSTRACT Background: Myotonic dystrophy type 1 (DM1) is a neuromuscular multisystemic disorder with slowly progressive muscle weakness. The overall purpose of this thesis was, in adult patients with DM1, to investigate ... -
Non-stimulant interventions in ADHD
(2014-09-19)Aim: The overall aim of the thesis was to study alternative non-stimulant treatments for Attention Deficit Hyperactivity Disorder (ADHD) in children, adolescents and adults. Method: The thesis includes four studies ... -
In vitro and in vivo studies of artemisinin endoperoxides
(2014-08-29)Artemisinin and its semi-synthetic derivatives (eg. Artemether/ARM, artesunate/ARS, dihydroartemisinin/DHA) play an important role in combating malaria, and treatments containing an artemisinin derivative (artemisinin-based ... -
Community dwelling person’s perspective on functioning after stroke
(2014-08-29)Abstract Stroke is the second most common cause of death worldwide and the most common cause of long-term disability in adults. Disability following stroke results from the interaction between persons with impairments and ... -
The adjustable shunt valve in the treatment of adult hydrocephalus - Effect on clinical symptoms, intracranial pressure and complications
(2014-05-26)Background: Hydrocephalus causes impaired gait, balance, cognition and continence, all of which can be reversed by shunt treatment. Adjustable valves are commonly used in the shunt treatment of hydrocephalus but randomized ... -
Suicidal behavior in late life: population and patient perspectives
(2014-05-23)Older adults have high rates of suicide, and the strong role of depression is often emphasized in studies on suicidal behaviour in this age group. The literature regarding other factors is rather sparse. This thesis utilizes ... -
The role of the intermediate filament (nanofilament) protein nestin in neural progenitor cell and astrocyte differentiation
(2014-05-23)Nestin, a class VI intermediate filament (nanofilament) protein, is commonly used as a marker for neural stem/progenitor cells (NSPCs), but its role in neurogenesis remains elusive. Nestin is also expressed in immature and ... -
Central modulation of affective touch, pain and emotions in humans
(2014-05-15)Hedonic feelings – pleasure and displeasure – strongly motivate human behavior. When well-functioning, hedonic feelings guide adaptive decision-making that promotes survival and well-being. Specialized afferent systems ... -
Indicators for Behavioral Pain Rehabilitation. Impact and predictive value on assessment, patient selection, treatment and outcome.
(2014-05-05)Chronic musculoskeletal ‘non-specific’ pain is still highly prevalent, despite advances of the biopsychosocial model in pain care and interprofessional rehabilitation. According to national and international reports, one ... -
Clinical studies on long-term lithium treatment and kidney failure
(2014-05-05)Background: Lithium enjoys the strongest evidence among today’s mood stabilisers for long-term relapse prevention of bipolar disorders, and has been shown to reduce the risks of completed and attempted suicides. However, ... -
It´s never too late
(2014-04-15)The overall aim of this thesis was to evaluate the effects of health-promoting and disease-preventive interventions on health and frailty in very old community-dwelling persons, and to explore the participants’ experiences ...