Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi: Recent submissions
Visas titlar 261-280 av 437
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Mentally disordered offenders: a longitudinal study of forensic psychiatric assessments and criminal recidivism
(2013-08-27)Background: During history, mentally disordered offenders have been in focus regarding responsibility for their crimes and imposition of punishment. The boundary stone of legal consequences for mentally ill offenders has ... -
Effects of Psychosocial stress on DHEA and DHEA-S levels - Acute and Long-term effects
(2013-05-24)Background: Long-term psychosocial stress can cause and contribute to a wide range of psychological and somatic conditions, and accelerate aging. One of the consequences of long-term psychosocial stress may be a reduction in ... -
Characterisation and semi-mechanistic modelling of eflornithine pharmacokinetics and evalutation of prodrugs in oral treatment against late-stage human African trypanosomiasis
(2013-05-22)The present thesis explores the hypothesis that treatment of human African trypanosomiasis can be improved by characterising the enantioselective pharmacokinetics of eflornithine, and investigating the oral eflornithine ... -
The role of astrocytes in stroke, brain plasticity and neurogenesis
(2013-05-10)Astrocytes, one of the most abundant and heterogeneous cell types in the central nervous system, fulfill many important roles in the healthy and injured brain. This thesis investigates the role of astrocytes in the neurogenic ... -
Social phobia among the elderly
(2013-05-02)Background: Social phobia is common and often associated with impairment in daily activities and reduced quality of life. Comorbidity with depression and other anxiety disorders is not unusual in social phobia. Few studies ... -
Physical activity among patients undergoing bariatric surgery
(2013-04-30)The World Health Organization (WHO) recommend that adults should perform ≥150 minutes of moderate intensity physical activity or ≥75 minutes of vigorous intensity physical activity or an equivalent combination of ... -
Cerebrospinal Fluid Biomarkers in Neurodegenerative Movement Disorders: Parkinsonian Disorders and Huntington's Disease
(2013-04-29)Background: Parkinson’s disease (PD) and atypical parkinsonian disorders (APD) [multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD)] are a large group of idiopathic ... -
Investigation of the pathophysiology of progression in multiple sclerosis: studies on cerebrospinal fluid biomarkers
(2013-04-23)Multiple Sclerosis (MS) is considered an autoimmune disease of the central nervous system (CNS). It usually starts with a relapsing remitting (RR) course that eventually transforms into progressive (P)MS, showing ... -
Hearing symptoms in children and adolescents - Tinnitus and temporary threshold shift
(2013-04-10)This thesis has assessed the prevalence of spontaneous tinnitus (ST), noise-induced tinnitus (NIT) and temporary threshold shift (TTS) in children and adolescents as well as investigated some of the audiometric, medical ... -
Neurobiological markers for personality, inflammation and stress: A naturalistic study in knee arthroplastic patients
(2013-03-25)Background: Psychiatry has strived to identify biomarkers elucidating the underlying biological mechanisms behind different disorders, to help in diagnostics and to assess treatment effects. In forensic psychiatric ... -
Hereditary diffuse leukoencephalopathy with spheroids: Insights into an adult onset neurodegenerative disease
(2013-03-25)During the last three decades, the areas of inherited white matter (WM) disorders have expanded. Advances in magnetic resonance imaging (MRI) and genetics have led to increased detection of adult-onset WM disorders. ... -
Airway reactions and breathing movements in sensory hyperreactivity
(2013-03-05)Abstract Patients diagnosed with sensory hyperreactivity, SHR, suffer from upper and lower airway symptoms like cough, difficulties to breathe and chest pain, induced by a variety of environmental irritants but also by ... -
Purinergic effects in the rat urinary bladder. Functional studies of cyclophosphamide treatment on afferent and efferent mechanisms
(2013-02-27)Pathological conditions in the lower urinary tract are common and have a great impact on the quality of life for the patients suffering from such disorders. In this thesis cyclophosphamide (CYP)-induced cystitis, a ... -
Hearing and middle ear status in children and young adults with cleft palate
(2013-02-27)Objective: The overall aim of this thesis was to define the hearing and prevalence of abnormal middle ear status across childhood and into young adulthood and attempt to understand the effects of a higher prevalence of ... -
Polycystic ovary syndrome - Effect of acupuncture on insulin resistance and neuroendocrine function
(2013-02-08)Although polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women in reproductive age the etiology and pathophysiology are poorly understood. PCOS is characterized by hyperandrogenism, polycystic ... -
Development of nursing programme to assist medical treatment in early onset Alzheimer's disease
(2013-01-25)Alzheimer´s disease (AD) is accompanied by neural degeneration with loss off dendrites and synapses. The ganglioside GM1 has been shown, but not in AD, to have positive influence on the nerve cells and stimulate growth of ... -
Volumetric assessment of hippocampus and cerebral white matter lesions in structural MRI
(2013-01-02)Assessment in structural MRI like hippocampal volumetry and white matter lesion (WML) assessment is receiving widespread attention and recommen-dation as important research and diagnostic tools. The aim in this thesis is ... -
Quantitative Clinical Pharmacological Studies on Efavirenz and Atazanavir in the Treatment of HIV-1 Infection
(2012-11-22)There are 34 million people infected with the HIV-1 virus in the world today. Due to increased access to antiretroviral therapy, AIDS related death has dropped by 30% since 2005. Optimizing the pharmacotherapy of the HIV-1 ... -
Induction of the cytoskeletal protein radixin in the adult brain
(2012-11-22)Abstract Neural stem and progenitor cells (NSPCs) proliferate throughout life in two regions of the brain, namely the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone of dentate gyrus in the ... -
Physical performance and physical activity in the later stage post-stroke
(2012-11-21)Aims: The overall purpose of this thesis was to increase knowledge about physical performance and activity in the later stage post-stroke by measuring walking performance in different environments coupled to muscle strength, ...