Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi: Recent submissions
Visas titlar 81-100 av 437
-
Depression among Swedish 70-year-olds - Sex differences from a gender perspective
(2020-04-28)Depression is one of the leading causes of global burden of disease. Due to increased life expectancy, late-life depression is an escalating public health issue. The prevalence is reported to be almost twice as high among ... -
On Aging, Behavior and the Role of PA28αβ in Protein Homeostasis
(2020-04-23)As life expectancy increases, understanding challenges related to the processes of aging are more relevant than ever. Common age-related diseases progress as consequences of accumulative protein damage and protein aggregates. ... -
Physical fitness and exercise in adults with congenital heart disease
(2020-04-14)Background: The population of patients with adult congenital heart disease (ACHD) is growing, and the estimated life expectancy has increased. Therefore, factors related to lifestyle, such as physical activity (PA), exercise, ... -
Functional studies of purinergic and cholinergic interactions in the rat urinary bladder - Characterization of ATP-evoked urothelial release of acetylcholine
(2020-03-26)Functional interplays between different transmitter systems are known to affect the signalling of the micturition reflex arc. The functional implications of many of these interactions, such as between ATP and acetylcholine, ... -
The physiological processing of Alzheimer-associated amyloid beta precursor protein in human and animal-derived neuronal models
(2020-02-27)Alzheimer’s disease (AD) is characterized by cognitive impairment due to the loss of structure and/or function of neurons, and amyloid plaques composed of aggregated-amyloid beta (Aβ) peptides, primarily species ending at ... -
Ghrelin in feeding: new insights into its role and the neurocircuits involved
(2020-02-27)Appetite, originally evolved to ensure we consume enough of diverse nutrients to survive famines, has lost its survival advantage in our modern society, where food is plentiful. The hedonic aspect of appetite can indeed ... -
Bipolar disorders: Subtypes, treatments, and health inequalities
(2020-02-18)This thesis comprises five studies based on prospective, longitudinal data from the Swedish national quality register BipoläR. Study I examined the differences between bipolar subtype I and II with respect to clinical ... -
Febrile Seizures and associated neurodevelopmental disorder
(2020-01-22)Background: Febrile seizures (FS) are common in young children. There is a lack of knowledge about possible associations between FS and the child’s cognitive and behavioural development. Aim: Gain further insight into the ... -
Radiological and Clinical Changes in Idiopathic Normal Pressure Hydrocephalus: MRI, Vascular factors and Clinical Symptoms as Markers of Pathophysiology and Prognosis
(2020-01-15)Idiopathic normal pressure hydrocephalus (iNPH) is a treatable, neurological disorder affecting the elderly population causing gait, balance, cognitive and micturition impairments. Treatment results in a clinical improvement ... -
Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury
(2020-01-07)Perinatal complications such as asphyxia can cause brain injuries that are often associated with subsequent neurological deficits. The mechanisms of perinatal brain injury are not fully understood, but mitochondria play a ... -
Life is doing. Facilitators and hindrances for occupational performance in adults with cerebral palsy - including methods of intervention
(2019-12-12)Introduction: Occupational performance is a complex process which poses difficulties to persons with CP even where they have relatively good motor function. Aim: To explore and describe the perception of occupational ... -
Changes in writing processes caused by post-stroke aphasia or low-grade glioma
(2019-12-11)Background: Writing is a cognitively and linguistically complex task, therefore sensitive to impairment caused by the presence and surgical removal of low-grade glioma or presence of post-stroke aphasia. Purposes: The ... -
Central actions of glucagon-like peptide-1 on food intake and reward: Novel neurological targets and sex divergent effects
(2019-12-06)Obesity is one of the biggest health risks of our society; however, treatment options are sparse and often result in suboptimal weight-loss. The glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist liraglutide was ... -
Exercise in older adults with rheumatoid arthritis - a person-centred approach
(2019-11-20)Physical activity and exercise are well known to enhance health and are recommended as part of the management of rheumatoid arthritis (RA). However, the level of physical activity among older adults with RA is found to be ... -
Spinal mobility, muscle strength and function in patients with idiopathic scoliosis. Different aspects on long term outcome
(2019-11-19)Introduction: The long-term physical function outcome in patients treated for idiopathic scoliosis (IS) during childhood and adolescence has not been fully explored. In addition, there is a lack of studies where different ... -
Taurine and dopamine-related effects of ethanol. An experimental study in rodents
(2019-11-18)The reinforcing properties of alcohol (ethanol) are associated with activation of the mesolimbic dopamine system and the concomitant increase in dopamine in the nucleus accumbens (nAc). Changes in this system are thought ... -
In vitro models of the blood brain-barrier using iPSC-derived cells
(2019-11-18)The blood-brain barrier (BBB) constitutes the interface between the blood and the brain tissue. Its primary function is to maintain the tightly controlled microenvironment of the brain. Models of the BBB are useful for ... -
On detection, treatment and prevention of complications in paediatric cataract surgery
(2019-11-06)Purpose: To find and validate methods for diagnosis, treatment and prevention of complications in paediatric cataract surgery. Background: Cataract and glaucoma are major treatable blinding conditions in children. Surgery ... -
The gut-brain axis and alcohol-mediated behaviours: the amylin story
(2019-10-29)Alcohol use disorder (AUD) is a complex neuropsychiatric disorder with high rates of mortality and morbidity. The currently available pharmacotherapies show varied efficacy, leading to the investigation of new neurochemical ... -
Surgical and neurological adverse effects of epilepsy surgery
(2019-10-16)The aim of this thesis was to study surgical and neurological complications of preoperative invasive investigations and epilepsy surgery procedures (Papers I-II) and seizure worsening after epilepsy surgery (Paper III). A ...