Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi: Recent submissions
Now showing items 381-400 of 437
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Metabolic and ovarian consequences of perinatal sex steroid programming
(2008-11-24)Endocrine and metabolic disturbances in adulthood may stem from insults such as nutritional and hormonal alterations that occur at critical periods in pre- or postnatal life – a process known as programming. This means ... -
The Role of Mammalian Target of Rapamycin in the Regulation of Amino Acid Transporters in the Human Placenta
(2008-11-14)Abnormal fetal growth, which is associated with both perinatal morbidity as well as metabolic diseases in adulthood, is an important clinical problem affecting as many as 15% of all pregnancies. However, to this date, there ... -
The effect of astrocytes and reactive gliosis on neurogenesis and astrogenesis in mice
(2008-11-10)Astrocytes are the most common cell type in mammalian central nervous system (CNS). Glial fibrillary acidic protein (GFAP) and vimentin constitute intermediate filaments (known also as nanofilaments), a part of the ... -
Cytochrome P450 enzymes affected by artemisinin antimalarials-pharmacokinetic and pharmacogenetic aspects
(2008-11-03)With more than 500 million cases and at least 1 million deaths each year, malaria is a major global health problem. The main problem with malaria control is the emerging drug resistance among parasites causing the infection. ... -
On the influence of serotonin- and sex steroid-related genetic variation on mood, anxiety, personality, autism and transsexualism
(2008-10-17)Background: The neurotransmitter serotonin has been related to mood and anxiety, and variation in genes that encode important members of the serotonergic system may hence affect mood- and anxiety-related traits. Sex steroids ... -
Life after hip fracture - Impact of home rehabilitation versus conventional care and patients' experiences of the recovery process in a short- and long-term perspective
(2008-10-14)Aim In a short- and long-term perspective compare a geriatric home rehabilitation programme (HR) for patients with hip fracture with conventional care (CC), and to capture the patients experience of the consequences of ... -
Congenital muscular torticollis
(2008-10-01)Aim: The purpose of these studies was to undertake a survey of functional and cosmetic status in children treated for congenital muscular torticollis (CMT), to examine validity and reliability of the Muscle Function Scale ... -
Work-related stress in women. Assessment, prevalence and return to work.
(2008-08-25)Aim: The overall aim of this thesis was to learn about work-related stress in women and the return to work possibilities, and to develop a questionnaire for assessing work-related stress in women. Method: The thesis is ... -
Cytochrome P450 2E1 - relevance for central dopamine neurotransmission and Parkinson's disease
(2008-08-25)Introduction: The enzyme cytochrome P450 2E1 (CYP2E1) has been found in dopamine (DA) containing brain regions that are of relevance for Parkinson’s disease (PD), and is known to generate reactive oxygen species (ROS), ... -
The effect of massage for women with breast cancer
(2008-06-30)ABSTRACT Breast cancer is the most common type of cancer in females. The effect of massage in the field of oncology has been investigated to some extent. The present thesis explored the effect of light pressure effleurage ... -
Cognitive profiles of vascular and neurodegenerative MCI
(2008-06-30)The objective of the thesis was to investigate the cognitive profiles of different types of mild cognitive impairment (MCI) and follow their course over time. Would it be possible to differentiate between “benign” and ... -
Brain Regeneration - in vitro and in vivo studies of exercise-related effects on brain plasticity
(2008-06-13)Neural stem and progenitor cells in the germinal regions of the adult brain, such as the hippocampus, are of great interest, because they provide the possibility for enhanced brain plasticity or can contribute to endogenous ... -
Studies on energy expenditure in walking after stroke
(2008-06-13)Aims: The aims were to assess energy expenditure during different conditions, evaluate measurement methods and assess physical activity after stroke. Methods: In total 51 persons with stroke >6 months previously (mean ... -
Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury
(2008-05-13)Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of acute mortality and neurological morbidity in infants and children. The mechanisms of perinatal HI are not fully understood, ... -
Influence of serotonin-related genes on behavior and body weight
(2008-05-06)Rationale: The neurotransmitter serotonin has been implicated in the regulation of normal behaviors, including food intake, and attributed importance for a variety of common psychiatric conditions, including major depression, ... -
Diffusion Tensor Imaging and Tractography in Epilepsy Surgery Candidates
(2008-04-25)In selected patients with medically refractory epilepsy, surgical treatment can render the patients seizure free or significantly reduce seizure frequency. Temporal lobe resection (TLR) for temporal lobe epilepsy (TLE) is ... -
Dementia and other mental disorders among 95-year olds
(2008-04-17)The aims of this study were to estimate the prevalence of mental disorders and age related differences in the very elderly. In addition, five-year mortality after age 95 in relation to dementia and cognitive function in ... -
Proteomic strategies for analysis of cerebrospinal fluid in neurodegenerative disorders
(2008-04-04)ABSTRACT There is a great need for biomarkers to diagnose neurodegenerative disorders, such as the cognitive disorders Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Cerebrospinal fluid (CSF) is in contact ... -
GLIAL HEMICHANNELS: A NEW ROUTE FOR CHEMICAL COMMUNICATION IN BRAIN
(2008-03-25)The extracellular neurochemistry determines normal brain function and the faith of neurons after insults such as stroke. This thesis concerns the effect of extracellular events related to intense neuronal stimulation and ... -
Astrocytic communication and cell death during metabolic depression and oxidative stress
(2008-03-19)Stroke is a major cause of death and adult disability in the western world. Most often, stroke is caused by the occlusion of a brain artery. Within the perfusion territory of the occluded vessel, various degrees of necrotic ...