Institute of Medicine / Institutionen för medicin: Recent submissions
Now showing items 141-160 of 1073
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Statins, Lipids, and Mutations: Consequences for the Heart and Immune System
(2019-08-14)CAAX proteins are a group of proteins that undergo a three-step protein maturation process that renders the proteins carboxyl-terminus hydrophobic and prone to localize to cellular membranes, where they have their primary ... -
Sköldkörtelsjukdom i Ronneby
(Arbets- och miljömedicin, Göteborgs universitet, 2019-06-28)I december 2013 upptäcktes höga halter av högfluorerade ämnen (så kallade PFAS) i ett vattenverk, som försörjde ⅓ av hushållen i Ronneby kommun med dricksvatten. För att undersöka om PFAS-föroreningen har lett till en ökad ... -
Samverkan vid vårdplanering för patienter med komplexa behov – ett mellanorganisatoriskt triangeldrama
(2019-05-22)Aims: The overall aim of this thesis was to deepen the knowledge of collaboration in care planning across healthcare provider boundaries for patients with complex care needs. Specific aims were: to highlight specialist ... -
Impact of chronic total occlusions, arterial access site, and pretreatment with antiplatelet drugs on mortality in patients with ischemic heart disease: A report from the SWEDEHEART registry.
(2019-05-17)Impact of chronic total occlusions, arterial access site and pretreatment with antiplatelet drugs on mortality in patients with ischemic heart disease: A report from the SWEDEHEART registry Background Treatment of ischemic ... -
Effects of gastric bypass surgery in patients with obesity and type 2 diabetes
(2019-05-17)Background: The effects of Roux-en-Y gastric bypass (GBP) have not been adequately explored in patients with concurrent obesity and type 2 diabetes mellitus (T2DM) to the same extent as has occurred for individuals with ... -
Systematiska kunskapsöversikter; 14. Kan arbeid over skulderhøyde forårsake skulderlidelser – en systematisk litteraturgjennomgang
(Arbets- och miljömedicin, Göteborgs universitet, 2019-05-14)Arbeid med hevete armer har vært regnet som en risikofaktor for skulderlidelser, men noen systematiske kritiske litteraturgjennomganger av arbeidsrelaterte risikofaktorer konkluderer med at det ikke er tilstrekkelig bevis ... -
Work ability and exposure to work demands among workers with neck pain
(2019-05-13)Neck pain is one of the most common musculoskeletal disorders, which causes sickness absence and early retirement. Manual labor, awkward postures and repetitive work are commonly reported as causes for work-related neck ... -
Thymic studies. Investigations into the effects of childhood thymectomy, and characterization of thymic B cells and Hassall's corpuscles
(2019-04-23)This thesis focuses on the human thymus, a primary lymphoid organ responsible for the maturation of T cells. Progenitors arrive from the bone marrow and start to randomly assemble their T cell receptor (TCR) followed by a ... -
Smoking and T cell co-stimulation in rheumatoid arthritis
(2019-04-18)In this thesis I investigated if smoking limits the co-stimulatory system of CD8+ T cells in rheumatoid arthritis (RA). I took special interest in the co-inhibitory receptor PD-1 and its ligand PD-L1. Blood samples from ... -
B cell subpopulations in the pathogenesis of rheumatoid arthritis
(2019-04-04)B cell depleting therapy has proven to be an effective treatment in rheumatoid arthritis (RA), a disease characterized by the presence of autoantibodies against citrullinated proteins (ACPA) and the Fc portion of IgG ... -
Female genital Graft-versus-Host Disease - Diagnosis, Treatment, Incidence, Long-term Prevalence, and Impact on Androgen Hormones and Sexual Function
(2019-03-28)ABSTRACT BACKGROUND. Chronic graft-versus-host disease (cGvHD) is the major cause of morbidity after allogeneic hematopoietic stem cell transplantation (alloSCT), and contributes to non-relapse mortality. Caused by donor ... -
Isolation Strategies and Proteomic Characterization of Extracellular Vesicles
(2019-03-15)“Extracellular vesicles” is the collective term used to describe vesicular entities that are released from cells into the extracellular environment. These vesicles are composed of a delineating lipid membrane and its cargo ... -
Intimate partner violence, sociodemographic factors and mental health among population based samples in Sweden
(2019-03-13)Aims: To explore the prevalence of Intimate Partner Violence (IPV) and its association with sociodemographic factors, symptoms of depression, perceived need for mental care and primary health care utilization. Another ... -
En svensk arbetsmiljöhistoria – Arbetsmiljöinstituten och företagshälsovården
(Arbets- och miljömedicin, Göteborgs universitet, 2018-12-15)I Arbete och Hälsa har det under de första 50 åren sedan starten 1967 publicerats 1076 artiklar och rapporter. Innehållet speglar till viss del hur arbetsmiljön har förändrats under dessa år. Redan tidigt i industrialiserings ... -
Childhood Body Mass Index and Pubertal Timing - Changes over time and associations with adult cardiovascular mortality
(2019-02-21)Puberty in boys has long been an under-investigated area of research mainly due to the lack of an easily available pubertal marker, corresponding to menarche for girls. Using a unique, large, population-based cohort, ... -
Aspects of cost-effectiveness and feasibility of implementations for care of depressed persons in primary care - internet-based treatment and care manager organisation
(2019-01-18)Background: Depression is a major source of human suffering and a growing challenge for societies worldwide. The lion’s share of depressed persons in Sweden are diagnosed and treated in primary care. There is an urgent ... -
Androgen receptor signaling mechanisms in bone
(2018-12-13)Osteoporosis is a common age-related disease that increases the risk of fractures. Androgens are crucial for bone health in males. Although a substantial part of the effects of androgens on the skeleton is mediated via ... -
The Role of Estrogen Receptor α Signaling in the Regulation of Bone Mass
(2018-12-06)Estrogens are major regulators of skeletal growth and maintenance in both females and males. Estrogen receptor α (ERα) is the main mediator of estrogenic effects in bone. Thus, estrogen signaling via ERα is a target for ... -
Brain-Gut Interactions in Irritable Bowel Syndrome (IBS)
(2018-12-04)Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction defined by recurrent and longstanding abdominal pain and disturbed bowel habits. This thesis aims to deepen the knowledge about aberrant visceral ... -
Vitamin A and Bone: Studies in vivo and in vitro
(2018-11-28)Background: Excess vitamin A is associated with decreased cortical bone and increased risk of fractures in humans. The aim of the present thesis was to assess the importance of vitamin A on the skeleton and bone cells in ...