Institute of Medicine / Institutionen för medicin: Recent submissions
Now showing items 441-460 of 1073
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Endocrine and diagnostic aspects of cognitive impairment
(2013-04-30)Hormones like insulin-like growth factor-I (IGF-I), thyroid hormones, and sex steroids decrease with normal aging. It is, however, unclear whether low hormone levels are related to age-related conditions such as Alzheimer’s ... -
Self-tolerance in collagen induced arthritis
(2013-04-29)Rheumatoid arthritis (RA) is an autoimmune chronic disease that results in damage to tissues throughout the body due to the inability of the immune system in these patients to discriminate between self-tissues and foreign ... -
Hypertension and cardiovascular risk factors in women - a follow-up study forty years after hypertensive pregnancies
(2013-04-03)The aims of the thesis were to investigate the impact of pregnancy blood pressure, a current diagnosis of hypertension and blood pressure levels on neurohumoral, cardiovascular and metabolic status in postmenopausal women ... -
Impact of the GH-IGF-I axis in adults - pharmacogenetic and genetic association studies
(2013-03-28)Growth hormone (GH) is a polypeptide hormone which is secreted from the anterior pituitary in a pulsatile pattern. GH is best known by its strong effects on longitudinal growth in children, but the importance of GH is ... -
Environmental exposure to fine particles in Gothenburg - personal exposure and its variability, indoor and outdoor levels, and effects on biomarkers
(2013-03-25)Urban particulate air pollution has been associated with adverse health effects in epidemiological as well as experimental studies. The overall aim of this thesis was to characterize environmental exposure to fine particles ... -
Clinical study on osteoporosis in ankylosing spondylitis
(2013-03-25)ABSTRACT Ankylosing spondylitis (AS) is a disease characterized by chronic inflammation and osteoproliferation in the spine, leading to bony fusion (ankylosis) of the sacroiliacal joints, the growth of bony spurs ... -
Systematiska kunskapsöversikter; 3. Kan arbetsvillkor orsaka depressionstillstånd? En systematisk översyn över longitudinella studier i den vetenskapliga litteraturen.
(Arbets- och miljömedicin, Göteborgs universitet, 2013)Rapporten undersöker det vetenskapliga stödet för om psykosociala arbetsvillkor kan utlösa depression och depressiva symtom. I databasen PubMed har vi identifierat 42 longitudinella studier i internationella vetenskapliga ... -
Regulation of metabolism and inflammation in liver and skeletal muscle
(2013-02-19)Type 2 diabetes (T2D) is a complex metabolic disorder characterised by hyperinsulinaemia, hyperglycaemia and dyslipidaemia. Obesity is the major risk factor for development of insulin resistance, a main predictor of T2D. ... -
Primary Sclerosing Cholangitis. Epidemiological Aspects, Prevalence of Elevated IgG4 levels and Quality of Life.
(2013-02-08)ABSTRACT Primary Sclerosing Cholangitis: Epidemiological Aspects, Prevalence of Elevated IgG4 Levels, and Quality of Life Maria Benito de Valle, MD Department of Internal Medicine and Clinical Nutrition, Sahlgrenska ... -
Determinants of Peak Bone Mass in Men
(2013-01-25)Objective: The aim of this thesis was to identify, investigate and evaluate hereditary and environmental factors associated with peak bone mass or bone development in men. Method: All studies in the thesis were performed ... -
Exosomes and Exosomal RNA – A Way of Cell-to-Cell Communication
(2013-01-22)Exosomes are nano-sized extracellular vesicles of endocytic origin participating in cell-to-cell communication, partly by the transfer of exosomal RNA between cells. These extracellular vesicles are released by most cells ... -
147. Carbon monoxide
(Arbets- och miljömedicin, Göteborgs universitet, 2012)Carbon monoxide (CO) is an odourless and colourless gas produced by incomplete burning of carbon-based fuels. CO is also a constituent of tobacco smoke. Exposure to CO is common in many occupational areas, including ... -
Quality of drug treatment in older people - Focus on hip fracture patients and multi-dose drug dispensing
(2013-01-14)The aim of this thesis was to describe the quality of drug treatment (QDT) regarding fall-risk increasing (FRIDs) and fracture-preventing (FPDs) drugs in older hip fracture patients, to evaluate a method for improving such ... -
Optimizing the early treatment of a threatening myocardial infarction
(2013-01-09)Acute myocardial infarction is the single most common cause of death for both women and men in Sweden. Great efforts have, over the years, been made to improve immediate treatment and care of acute coronary syndromes. Through ... -
The role of estrogen receptor alpha in the regulation of bone and growth plate cartilage
(2012-12-20)Estrogens are important endocrine regulators of skeletal growth and maintenance in both females and males. Studies have demonstrated that the estrogen receptor (ER)-α is the main mediator of these estrogenic effects in ... -
Arthritis and immune-mediated bone loss - role of estrogen signalling pathways
(2012-12-13)Objective: Rheumatoid arthritis (RA) is associated with immune-mediated bone loss and thereby increased risk for fractures. Estrogen and selective estrogen receptor modulators (SERMs) ameliorate not only the incidence and ... -
Asthma in West Sweden - a translational study from epidemiology to proteomics
(2012-11-20)Asthma has been increasing in prevalence and morbidity, however it is unclear if the increase continues. Asthma has long been regarded as a single disease entity, but is now recognised as a heterogenic disease with different ... -
The role of melanocortin 1 receptor in kidney disease
(2012-11-15)Nephrotic syndrome is a term describing a group of poorly understood glomerular diseases that are responsible for a steadily increasing number of patients requiring active uremic care. Characteristic symptoms of nephrotic ... -
Diet and/or exercise treatment for weight loss in overweight and obese women after childbirth
(2012-11-15)AIM: The aim of the research presented in this thesis was to evaluate whether, dietary behavior modification treatment (D), or physical exercise behavior modification treatment (E), or the combination of both (DE), provide ... -
Implementation of gut-directed hypnotherapy for irritable bowel syndrome in clinical practice
(2012-11-14)Background: Irritable Bowel Syndrome (IBS) is characterized by recurrent abdominal pain or discomfort, related to abnormal bowel habits. This benign and common condition is in severe cases associated with bothersome GI ...