Institute of Clinical Sciences / Institutionen för kliniska vetenskaper: Recent submissions
Visas titlar 181-200 av 582
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Shoulder impingement; Evaluation of the clinical outcome, radiographic findings, histology, ultrastructure and biochemistry
(2018-11-16)This thesis had two main purposes: on the one hand, to assess and evaluate the clinical outcome of different treatment strategies for subacromial impingement syndrome (SAIS), in both the short and the long term and, on the ... -
Lung and chest wall properties during mechanical ventilation
(2018-11-16)Background: Mechanical ventilation causes injury to the lungs due to high pressures and high volumes. Pressure affecting the lungs, the transpulmonary pressure, needs to be monitored to minimise harmful side effects but ... -
Cardiopulmonary bypass and the kidney - studies on patients undergoing cardiac surgery
(2018-11-12)Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass (CPB), and has a major impact on morbidity, mortality and costs. The mechanism of CPB-related renal impairment is not fully ... -
Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies
(2018-11-06)ABSTRACT Neuroendocrine tumours (NET) often present at a metastatic stage, which diminishes the possibility for curative surgery. Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE targets somatostatin receptors, ... -
Genetic factors affecting pregnancy duration in humans
(2018-11-01)This thesis investigates the mechanisms behind human pregnancy duration. Too short gestation is a direct cause of perinatal, neonatal, and infant mortality. Deviation from normal pregnancy length is also associated with a ... -
Human growth patterns - with focus on pubertal growth and secular changes
(2018-10-30)Introduction: Human growth is a dynamic process, an indicator of health and disease. Previous used growth models have been limited in describing the pubertal growth spurt. ... -
Intravoxel incoherent motion modeling - Optimization of acquisition, analysis and tumor tissue characterization
(2018-09-13)Intravoxel incoherent motion (IVIM) analysis provides a means to obtain information on diffusion and perfusion from a single MRI sequence. The measurements are completely noninvasive and the results have been shown to be ... -
Genetic Studies of Familial Vesicoureteral Reflux
(2018-08-31)Vesicoureteral reflux (VUR) is a common congenital anomaly with a high risk of recurrent urinary tract infections (UTI) and, as a consequence, scarring of the renal parenchyma. Additionally, high-grade reflux is often ... -
Potential Therapeutic Applications of Novel Bioengineered Tissues and Organs Using Methods of Decellularization and Recellularization
(2018-09-04)The transplantation of personalized organs or tissues will benefit patients with various diseases and disorders. Decellularization is a method to generate an acellular, non-immunogenic natural scaffold. The personalized ... -
Nutritional aspects of advanced Head and Neck Cancer and impact of different factors in Head and Neck Cancer of Unknown Primary
(2018-05-25)Background/Aims: Swallowing problems and malnutrition are common in advanced head and neck (HN) cancer. The aim of paper I was to study whether percutaneous endoscopic gastrostomy (PEG) affected the long-term swallowing ... -
Left-sided obstructive cardiac lesions in the fetus and the neonate
(2018-05-21)ABSTRACT Introduction Hypoplastic left heart syndrome (HLHS) is a severe cardiac malformation, fatal in the neonatal period in the absence of immediate care. Palliative surgery for HLHS has been available in Sweden since ... -
Esophagitis: Aspects on bacteriology, pathophysiology and symptomatology
(2018-05-18)Gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are the two most common diseases causing inflammation of the esophagus, namely, esophagitis. GERD and EoE are different in many aspects, but ... -
Ovarian stimulation for IVF-a balance between efficacy and safety
(2018-05-18)Background: To increase the chance of a live birth after in vitro fertilization (IVF) a controlled ovarian hormonal hyperstimulation (COH) is used to collect a certain number of oocytes for fertilization. COH is a potent ... -
The clinical utility of patient-reported outcome measures in total hip replacement and lumbar spine surgery
(2018-05-15)Background: Beginning in the late 1990s, the Swedish Hip Arthroplasty Register (SHAR) and the Swespine have successfully implemented programs to collect patient-reported outcomes measures (PROMs). The use of PROMs has ... -
Hypospadias surgery - long-term outcome focusing on adolescence
(2018-05-09)Hypospadias is a malformation that affects 1/125 born boys in Sweden. 1/10 with hypospadias are born with the most severe form; proximal hypospadias. The treatment, which is surgical, is performed during the first years ... -
Contraception and unplanned pregnancies
(2018-05-09)Aims: The overall aim of this thesis was to describe the relationship between contraceptive use, abortion, birth and fertility rates among women in different age groups in Sweden and the other Nordic countries. Material ... -
Ex Vivo Lung Perfusion - experimental and clinical studies
(2018-05-07)Background: Ex vivo lung perfusion (EVLP) has since its introduction in clinical practice experienced a rapid expansion and made more organs available for transplantation. Different protocols and strategies have been ... -
Clinical and radiographic evaluation after ACL reconstruction with the emphasis on surgical technique and time of reconstruction
(2018-05-07)The overall purpose of this thesis was to assess the short-, mid- and long-term clinical and radiographic results after anterior cruciate ligament (ACL) reconstruction, in relation to different surgical techniques, such ... -
Surgical methods in treating pancreatic tumours
(2018-05-03)Background: In patients with pancreatic cancer 15-20% are resectable at the time of diagnosis. Still another 8-20% are found to be unresectable at laparotomy. The optimal intraoperative strategy for this group is not known. ... -
Health economic aspects of minimally invasive surgical techniques
(2018-04-25)The aim of this thesis was to compare minimally invasive- with traditional open surgical techniques for various diseases with regards to cost-effectiveness. Health economic evaluations were performed using data from ...