Institute of Clinical Sciences / Institutionen för kliniska vetenskaper: Recent submissions
Now showing items 241-260 of 582
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Maternal and placental inflammatory biomarkers in spontaneous preterm delivery - Predictive ability, stability and neonatal associations
(2017-03-28)Preterm delivery (PTD), spontaneous or iatrogenic, causes short- and long-term morbidity and underlies almost 75% of neonatal deaths. The prevalence in the Nordic countries is about 6% but it differs among countries. In ... -
Patient-reported outcomes in children and adolescents born with esophageal atresia - condition-specific aspects of health-related quality of life and coping
(2017-03-17)Background: Survival rates in children with esophageal atresia (EA) have reached 90-95%, but they are at risk of chronic morbidity, mainly related to esophageal and respiratory dysfunction. Knowledge of condition-specific ... -
Improving Emergency Medical System Response to Emergencies in a Middle-Income Country
(2017-03-16)Introduction: The main task for all Emergency Medical Services (EMS) is to save lives and be available to those with severe medical conditions. In both of the situations, a timely arrival by the ambulance is mandatory. ... -
The Diabetic Foot - assessment and assistive devices
(2017-02-28)Foot ulcers are a serious complication in diabetes and the most common factor leading to lower extremity amputation. The Swedish National Guidelines for Diabetes Care recommend an annual foot check for all 400,000 patients ... -
Spino-pelvic sagittal alignment and back and hip pain prevalence in young elite athletes
(2017-02-23)Young athletes that perform regular intense training and sports competions have been shown to increase the risk of low back pain (LBP). This may be the result of heavy loading in different planes to the spine, heavy training ... -
Lutetium-177-octreotate treatment of small intestine neu-roendocrine tumors - Radiation biology as basis for optimization
(2016-12-19)Patients with neuroendocrine tumors (NETs) often have metastatic spread at the time of diagnosis. NETs frequently express somatostatin receptors (SSTR) that can be targeted by radiolabeled somatostatin analogs (e.g. ... -
Optimization of image acquisition parameters in chest tomosynthesis - Experimental studies on pulmonary nodule assessment and perceived image quality
(2016-12-14)Chest tomosynthesis refers to the technique of acquiring a number of discrete projection images within a limited angular range around the patient. These projection images are then used to reconstruct section images of the ... -
Epidemiology of cutaneous malignant melanoma in Western Sweden
(2016-11-23)The incidence of cutaneous malignant melanoma (melanoma) has been rising worldwide for the past decades, causing a major public health problem. The overall aim for this thesis was to study the epidemiology of melanoma ... -
Thalidomide Embryopathy - Orthopaedic aspects. Degenerative changes and quality of life at age 45
(2016-11-18)In the late 1950s and early 1960s, a sudden peak was seen among children with different, severe malformations, caused by the intake of the drug thalidomide during pregnancy. Among other featured malformations, so-called ... -
Multiparametric MRI for evaluation of tumour treatment response
(2016-11-18)Clinical assessment of tumour response to treatment largely relies on estimates of tumour size by, e.g., measuring the largest tumour diameters on magnetic resonance (MR) or computed tomography (CT) images, weeks or ... -
Urethral strictures in men: Studies on reconstructive surgery and pathophysiology
(2016-11-14)Urethral stricture is a common disease that is characterised by fibrotic tissue arising from inflammation after urethral injury. Urination is inhibited when there is total obstruction, and the suffering is immense. Following ... -
Estimation of clinical dose distributions for breast and lung cancer radiotherapy treatments
(2016-11-07)The overall aim of this thesis was to investigate the uncertainties in the dose distribution determined at the treatment planning stage. The work has been based on the main hypothesis that the way of determining dose at ... -
Development of methods for analysis and reconstruction of nuclear medicine images
(2016-10-25)This thesis presents four novel algorithms for processing and analysis of nuclear medicine images. In addition, the novel research image platform where these four algorithms have been implemented, together with most ... -
Quality of life and morbidity in patients with rectal cancer
(2016-10-24)Aim: The aim of this thesis was to investigate patient-reported and clinical outcome in patients with rectal cancer with specific focus on treatment-associated morbidity and quality of life. Method: Three clinical studies ... -
Barretts esophagus - aspects on early detection of malignant transformation
(2016-10-20)Background: Barrett’s esophagus (BE) is a metaplastic mucosal transformation adjacent to the gastroesophageal junction, due to chronic reflux of gastric juices. BE is associated to an increased risk of esophageal adenocarcinoma ... -
Abdominoperineal excision for distal rectal carcinoma. Oncological outcome and aspects of self-assessed quality of life
(2016-09-15)Abstract: In recent years an adjusted method of performing an abdominoperineal excision (APE) - so called extralevator APE - has been developed and internationally spread. It has been proposed to decrease intraoperative ... -
Bone and fat tissue in children and adolescents: studies with focus on osteocalcin
(2016-09-15)The general AIM was to investigate the possible interplay between bone and fat tissue through clinical studies of children and adolescents. Osteocalcin (OC), a bone formation marker, has been proposed to act as a link ... -
Narcolepsy in children: Relationship to the H1N1 influenza vaccination, association with psychiatric and cognitive impairments and consequences in daily life
(2016-09-06)Background/aims: Narcolepsy is a lifelong sleep disorder with an onset most frequently in the second decade of life. The cardinal symptoms are excessive daytime sleepiness, cataplexy, hypnagogic and hypnopompic hallucinations ... -
A methodological platform to study molecular biocompatibility of biomaterials. Experimental and clinical studies
(2016-05-13)The aim of this project was to develop a methodological platform in order to advance our scientific understanding of the mechanisms of osseointegration. Screw-shaped, titanium implants, with different surface properties, ... -
On the effect of repetitive loading on the spine of young elite athletes. Clinical and experimental studies
(2016-05-13)Introduction: The human spine is exposed to many different loads during daily activities and especially during sporting activities. The spine has different biomechanical properties during the lifetime and thereby responds ...