Department of Chemistry and Molecular Biology / Institutionen för kemi och molekylärbiologi (2012-): Recent submissions
Visas titlar 141-160 av 165
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The Mechanisms of Exocytosis Studied in Cells and Models with Amperometry
(2013-05-15)Exocytosis is the universal basis for neuronal communication, allowing the controlled release of neurotransmitter molecules from the presynaptic cell. Exocytosis has been widely studied in many systems. However, the details ... -
Iron catalyzed C-C coupling reactions - mechanistic investigations
(2013-05-14)The mechanism of the iron catalyzed cross coupling of aryl electrophiles with alkyl Grignard reagents was studied. The reaction proceeds via a rate-limiting oxidative addition of the aryl halide to an Fe(I) complex generated ... -
Advances in Membrane Protein Structural Biology: Lipidic Sponge Phase Crystallization, Time-Resolved Laue Diffraction and Serial Femtosecond Crystallography
(2013-05-08)Membrane proteins carry out many essential tasks in cells such as signaling and transport, or function as electron carriers in photosynthesis and cellular respiration. The aim of this thesis has been to develop new and ... -
Structural analyses of immune cell receptor signalling and activation
(2013-04-17)Structural biology is a scientific field where the aim is to observe macromolecules on a atomic level to understand their functions. Often these macromolecules are proteins that make, almost, everything happen within the ... -
Breaking the symmetry: creation and transfer of optical activity via total spontaneous resolution and stereoselective reactions
(2013-03-28)The generation of optical activity from achiral or racemic precursors – absolute asymmetric synthesis – is discussed in relation to the origin of biomolecular homochirality but is also often (incorrectly) regarded as ... -
Structural studies of aquporins in human kidney and plant
(2013-03-22)Membrane proteins are key players in our biology and are links between the inside and the outside of the cell, allowing for signal transduction and transport of molecules. Aquaporins are membrane protein channels that allow ... -
On the formation of small molecules by radiative association
(2013-03-05)This thesis is devoted to the theoretical investigation of radiative association, which is one of the processes contributing to formation of molecules in the interstellar medium. The formation of the CN, SiN, SiP and CO ... -
Formation, ageing and thermal properties of secondary organic aerosol
(2013-02-07)In order to properly represent and predict the effects of aerosol in climate systems, an accurate description of their formation and properties is needed. This thesis describes work done to increase the knowledge of processes ... -
Regulation and transport mechanisms of eukaryotic aquaporins
(2013-01-11)Aquaporins are found in all kingdoms of life where they are involved in water homeostasis. They are small transmembrane water conducting channels that belong to the ancient protein family Major Intrinsic Proteins (MIP). ... -
Algorithms and Interaction Potentials: phase density, surface tension and carbon dioxide
(2012-12-14)This thesis is an amalgamation of articles (Papers I–V) by the author. We present a perturbation algorithm to calculate the phase density, and thus the partition function including its temperature dependence. It works ... -
The Synthesis and Use of Certain Pyridine Derivatives as Modulators of the G-protein Coupled Receptors mGlu5 and P2Y12
(2012-11-20)The glutamatergic mGlu5 receptor and the purinergic P2Y12 receptor are two important targets in the development of novel treatments of gastroesophageal reflux disease (GERD) and thrombosis, respectively. Synthesis was ... -
Synthesis, Pharmacological Characterization and QSAR Modelling of 4-Phenylpiperidines and 4-Phenylpiperazines Effects on the dopaminergic neurotransmission in vivo
(2012-11-19)The endogenous neurotransmitter dopamine (DA) is involved in several functions that are controlled from the central nervous system (CNS), for example behaviour, memory, cognition and reward. A disturbed dopaminergic ... -
Static and Dynamic Measurements of Neurotransmitters in Drosophila Brain
(2012-11-15)Neurotransmitters, the substances neurons use for communication, and their precursors and metabolites are of obvious importance for the wellbeing of the individual and when the neurotransmitter balance is off it can lead ... -
Selectivity of dopamine D1 and D2 receptor agonists – A combined computational approach
(2012-10-26)Dopamine (DA) is an endogenous neurotransmitter acting in the central nervous system. DA plays a key role in many vital brain functions such as behavior, cognition, motor activity, learning, and reward. Dopamine receptors ... -
Formation and Distribution of Marine Biogenic Halocarbons with Emphasis on Polar Regions
(2012-10-19)It is well-established that marine micro- and macroalgae form volatile halogenated compounds (halocarbons). Production occurs throughout the world ocean with strong regional sources in coastal areas. In the atmosphere, ... -
Attenuation of acute inlammatory responses by surface nanotopography
(2012-10-04)The interaction between biology and non-viable surfaces is crucial for many organisms and cells. For example, bacterial cells need to adhere to mineral surfaces in the soil, plants climb and adhere to walls and marine ... -
Design, Synthesis, and Evaluation of Functionalized Chroman-4-one and Chromone Derivatives. Somatostatin receptor agonists and Sirt2 inhibitors
(2012-10-04)Peptides are involved in many physiological processes such as regulation of blood-pressure, food intake, pain transmission and blood-glucose levels. They consist of amino acids that are connected through amide bonds which ... -
Structural Insights at Sub-Ångstrom, Medium and Low Resolution: Crystallization of Trypsin, Bacterioferritin, Photosynthetic Reaction Center, and Photosynthetic Core Complex
(2012-09-28)The catalytic action of serine proteases depends on the interplay of a nucleophile, a general base and a general acid. The catalytic triad is composed of serine, histidine and aspartate residues. The serine acts as a ... -
Iron or Copper? - Method Development and Mechanistic Studies on Cross-Coupling Reactions
(2012-09-06)The area of catalysis has had an immeasurable impact on modern society. This has been acknowledged through several Nobel prizes during the 20th century ranging from Haber (1918) for the synthesis of ammonia to Richard ... -
Cellular Resilience and Fragility in Response to Environmental and Gene Expression Perturbations
(2012-08-30)Cells are constantly subjected to perturbations. Whether these are extracellular or intracellular, they can be detrimental to cellular fitness. The cell has evolved elaborate systems and mechanisms that allow it to remain ...