Department of Chemistry and Molecular Biology / Institutionen för kemi och molekylärbiologi (2012-): Recent submissions
Visas titlar 41-60 av 165
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Regulators of Membrane Fluidity
(2020-04-29)Caenorhabditis elegans PAQR-2 (a homolog of the mammalian AdipoR1 and AdipoR2 proteins) and IGLR-2 (homolog of the mammalian LRIG proteins) form a complex at the plasma membrane that regulates fatty acid desaturation to ... -
From Silica Nano-Particles to Silica Gels and Beyond - Salt Induced Aggregation of Silica Nano-Particles and the Stability of Resultant Gels
(2020-04-21)Aqueous silica nanoparticle suspensions are widely available and used within a number of industries. A relatively new area of application is as a grouting material for sealing narrow fractures in tunnels. While silica ... -
The Primary Structural Photo-Response of a Bacterial Phytochrome Probed by Serial Femtosecond Crystallography
(2020-04-14)Species across all kingdoms of life rely on the ability to sense different light conditions. Some organisms convert light into chemical energy via the reactions involved in photosynthesis, whereas others use it to trigger ... -
Protein Structural Dynamics Revealed by Time-Resolved X-ray Solution Scattering
(2020-02-11)Proteins fold in very specific three-dimensional structures within a few seconds. Highly complex and organized, their three-dimensional structure is closely related and often essential for their function. They perform a ... -
Salting-out of Colloidal Latex Particles Grafted with Poly(ethylene glycol)
(2020-01-15)Colloidal particles dispersed in a medium are important both in nature and in industry. The stability of colloidal particles is determined by the interactions between them and can be improved by steric stabilization. There ... -
Molecular-Level Investigations of Water-Organic Systems of Atmospheric Relevance
(2020-01-07)It is known that aerosol particles may have warming and/or cooling effects on the climate and negative health effects that depend on their chemical and physical properties. However, current understanding of atmospheric ... -
Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational approach
(2019-12-12)Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease that is the major mediator of the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress. The association ... -
Structure-based drug design applied to the antibacterial target MraY
(2019-12-10)Antibiotic resistance is one of the biggest threats to human health of our time. We are being warned of a so-called post-antibiotic era, where a simple surgery or bacterial infection could kill human beings. Without the ... -
Time Resolved Diffraction Studies of Structural Changes in Sensory Rhodopsin
(2019-11-29)Responding to different light conditions is an essential process for many organisms on earth. Unicellular organisms are no exception to this and mechanisms for controlling cellular movement must often be sensitive ... -
Microcrystallization in lipidic cubic phase and serial crystallography studies of cytochrome c oxidase
(2019-11-07)Life in all living organisms depend on chemical processes performed by proteins, which are molecular machineries encoded in the DNA. Cytochrome c oxidase (CcO) is a membrane protein essential for cellular respiration, a ... -
DNA checkpoint override and redox signaling in Schizosaccharomyces pombe
(2019-10-25)This thesis covers intracellular stress signaling through genotoxic stress, overriding of checkpoint control, as well as cellular redox status in hypoxic and oxidative stress Papers I and II: Caffeine has been shown to ... -
Electrochemical and microscopic analysis of chemical signalling in biological systems
(2019-10-01)Cellular communication is a prerequisite in multicellular organisms in order to survive. Many times, this communication occurs through the highly controlled and regulated release of chemical signals through a process known ... -
Anti-Virulence Strategy Targeting Sortase A, A Structural Investigation of the Sortase A Enzyme, and the Identification, Synthesis, and Evaluation of Sortase A Inhibitors
(2019-09-20)The emergence of multi-resistant bacteria and their continuous spread is one of the greatest challenges when treating bacterial infections. Increased understanding of bacterial pathogenesis has revealed new strategies for ... -
Molecular biology of barnacle Balanus improvisus settlement
(2019-09-13)The aim of this thesis was to investigate molecular mechanisms of various aspects of barnacle settlement, using the acorn barnacle Balanus improvisus. This barnacle is a common fouling species and a model organism for ... -
Development of Fluorescent Nucleobase Analogues - Intrinsically labelled nucleic acids for molecular binding investigations
(2019-09-04)This thesis focuses on the design, synthesis and utilization of fluorescent nucleobase analogues (FBAs). FBAs are an important class of compounds, used in the research of nucleic acids. The class of canonical FBAs, i.e. ... -
Micro-Crystallization and Time-Resolved Diffraction Studies of a Bacterial Photosynthetic Reaction Center
(2019-05-27)Photosynthesis is one of the most important set of chemical reactions in nature as they can convert sunlight into hydrocarbons and chemical energy. The proteins responsible for this are two general types of reaction centers ... -
Production and Structural Dynamics of Microbial Rhodopsins
(2019-05-22)Rhodopsins are a family of membrane proteins that are found in a wide range of organisms and provide them with the ability to sense and react to light. When light is absorbed by these proteins, structural changes occur ... -
Structural and Interaction Studies of the Human Protein Survivin.
(2019-03-14)Cell division and cell death (apoptosis) are two essential processes to maintain the specific number of cells in all multicellular organisms. In humans, the misregulation of these processes leads to severe diseases, such ... -
Secondary Organic Aerosols: Composition, Gas-to-Particle Partitioning and Physical Properties
(2019-02-21)Atmospheric aerosols influence our climate and air quality. Aerosol particles in the atmosphere are transformed through many different physical and chemical reactions. A substantial fraction of the particles in the ... -
Atmospheric Chemistry of Volatile Organic Compounds: Oxidation Products, Mechanisms and Secondary Organic Aerosol Formation
(2019-01-15)The results from this work are a piece in understanding the complex puzzle of atmospheric aerosol formation. Secondary organic aerosol (SOA) formed by the oxidation of volatile organic compounds (VOC) in the atmosphere ...