Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi: Recent submissions
Visas titlar 101-120 av 163
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Terahertz radiation as a pump and probe for studying low frequency vibrations in proteins
(2015-09-18)Many functionally important structural changes in proteins proceed along the direction of their lowest frequency vibrations. These vibrations correspond to picosecond collective dynamics. Establishing the fundamental ... -
Inhibition of the mevalonate pathway in C. elegans: Consequences and implications
(2015-09-15)The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q (a component of the electron transport chain in mitochondria), dolichols (important for ... -
Characterization of Amino Acid tRNA Ligases using the Analytical Ultracentrifuge
(2015-09-09)ABSTRACT. Quaternary structures of amino acid tRNA ligases/synthetases (aaRS) in the native as well as in denatured forms were examined by molecular weight determinations (paper I-IV). Analytical ultracentrifugation, ... -
Mass spectrometry based analysis of drugs, neurotransmitters and lipids in invertebrate model systems
(2015-09-07)Mass spectrometry (MS) is one of the most universal analytical techniques due to its label-free detection principle and high chemical specificity, high selectivity, and sensitivity. MS is diverse with many different types ... -
Carbonaceous Aerosol in Europe - out of the woods and into the blue?
(2015-09-03)Particulate matter (PM) in the atmosphere influences weather and climate and may have important health impacts. Regional scale chemical transport modelling aims to describe the composition of particulate matter, to track ... -
Nanoparticles from shipping and road traffic
(2015-05-07)In the urban environment road traffic is the dominant source of aerosol particles while in coastal and harbour areas shipping is also a significant source. For shipping there are no direct regulations regarding particle ... -
Adaptation and Protein Quality Control Under Metalloid Stress
(2015-04-22)Toxic metals and metalloids are emerging as major environmental pollutants, having ecological consequences as well as being linked to a broad range of degenerative conditions in animals, plants and humans. While the toxicity ... -
Plant aquaporin regulation: Structural and functional studies using diffraction and scattering techniques
(2015-03-27)Water is the basis for life as we know it. It is only logical then that all organisms have evolved specialized proteins, aquaporins, which regulate water flow across their membranes. Plants, which are immobile, depend more ... -
Inhibition of the MDM2/p53 Interaction Design, Synthesis and Evaluation of MDM2 Inhibitors
(2015-02-20)Numerous essential cellular processes are regulated by protein-protein interactions (PPIs) and PPIs have therefore been recognised as potential new drug targets. The transcription factor p53 is often referred to as the ... -
Purine and Pyrazolopyrimidine Derivatives: Design and Synthesis of Chemical Tools for Biological Applications
(2014-12-04)Purines can be found in a multitude of naturally occurring compounds with a range of functions. This thesis describes the design and synthesis of purines and structurally related pyrazolopyrimidine derivatives intended for ... -
Modulating Sirtuin Activity - Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors
(2014-11-21)Sirtuins (SIRTs) are NAD+-dependent lysine deacetylating enzymes targeting histones and a multitude of non-histone proteins. The SIRTs have been related to important cellular processes such as gene expression, cell ... -
X-ray free-electron laser based methods for structural and ultrafast dynamics studies of a photosynthetic reaction centre
(2014-11-14)Life on earth is fuelled by the energy of sunlight, which must first be captured and converted into a chemical energy form useful to the cell. This process is known as photosynthesis and the major pathway of this energy ... -
Intrinsically Disordered Domains of the B Cell Receptor Cell-Free Expression and Characterization by NMR
(2014-10-23)After the last twenty years of research, the occurrence of flexible proteins without a fixed three-dimensional structure are no longer considered to be rare exceptions from the structure-function paradigm. Instead, ... -
Conformational Flexibility in Protein Function: Dynamics of S100A4, Photosynthetic Reaction Centre and the Prenylating Enzymes UbiA and MenA
(2014-09-11)Proteins are the most versatile macromolecules and they are essentially involved in the biological processes throughout all living organisms. The three dimensional structure of proteins and their dynamical properties ... -
On aging and the role of Ubp3 in heterochromatic gene silencing and protein quality control
(2014-09-04)Aging is characterized by a build-up of damage in organisms ranging from protists to multi-cellular species. This damage adversely affects core components such as DNA and proteins which are necessary to sustain life. ... -
Molecular mechanisms of ovarian follicular development and early embryogenesis
(2014-05-19)In the mammalian ovary, the dormant primordial follicles are the source of developing follicles and fertilizable ova for the entire reproductive life. In addition, the duration of fertility of a female is determined by ... -
Dynamic control of the yeast AMPK/SNF1 pathway in response to glucose signals
(2014-05-15)The SNF1/AMP-activated protein kinase (AMPK) belongs to a family of energy sensors that is conserved in all eukaryotes. Activated by ATP depletion, AMPK plays a vital role in restoring the energy balance by enhancing ... -
Molecular investigations of atmospherically relevant interface processes: ice formation and water accommodation on ice and organic surfaces
(2014-05-12)Clouds and aerosols play important roles in the climate system by affecting on atmospheric chemistry, the radiation budget of the atmosphere, and the water cycle including the formation of precipitation. Climate models ... -
FoxF genes in development and disease
(2014-05-08)Forkhead transcription factors of the FoxF group are important during embryonic de-velopment, and mutation of either of the members, Foxf1 and Foxf2, has fatal conse-quences. In this thesis, I present our recent findings ... -
The Marine Carbonate System: Ionic Interactions and Biogeochemical Processes
(2014-05-07)The absorption of atmospheric carbon dioxide (CO2) by seawater and subsequent equilibrium reactions within this ionic medium give rise to a complex chemical system often referred to as the marine carbonate system. This ...