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  • School of Business, Economics and Law / Handelshögskolan
  • Department of Statistics / Institutionen för statistik (-2002)
  • Research Report
  • Redigera dokument
  •   Startsida
  • School of Business, Economics and Law / Handelshögskolan
  • Department of Statistics / Institutionen för statistik (-2002)
  • Research Report
  • Redigera dokument
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A comprative study of some approaches for constructing tolerance limits

Sammanfattning
In a dose finding study the aim is to come up with a safe and efficient drug administration. By comparing the obtained tolerance limits with predetermined desired concentration limits, i.e. the therapeutic window, one may be able to adjust the drug dosage. For drugs with a therapeutic window situated at high concentrations close to toxic levels, one has to balance between attaining a high proportion of the population at efficient high levels on one hand and the risks of an overdose on the other hand. In such cases it is important to use the proper estimation approach for the upper tolerance limit. Here a conservative estimation approach intended for a drug with potentially adverse side effects with minor overdoses is compared with an approach intended for a drug with harmless side effects. It is shown that the conservative approach can be considerably less efficient when used in the latter case, a disadvantage that is rarely discussed when proposing conservative estimators. The properties of the two approaches are evaluated using well-known parametric and non-parametric estimators in a simulation study for small and moderate sample sizes.
Universitet
Göteborg University. School of Business, Economics and Law
URL:
http://hdl.handle.net/2077/2964
Samlingar
  • Research Report
Fil(er)
comparative.pdf (150.1Kb)
Datum
2000
Författare
Petzold, Max
Nyckelord
conservative; dose finding study; non-parametric; order statistics; tolerance limits
Publikationstyp
Report
ISSN
0349-8034
Serie/rapportnr.
Research Report, nr 2000:2
Språk
en
Metadata
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