Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper
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The long-term effects of obstetrical anal sphincter injury on pelvic floor function
Background: As women live longer, the long-term effects of childbirth may negatively affect their quality of life and professional careers. Aim: This thesis investigates the long-term effects of vacuum extraction (VE) ... -
Markers and mechanisms of abnormal neurovascular development in the preterm infant
Background: The extremely preterm infant is at risk of lifelong neurodevelopmental impairments due to brain injuries or abnormal neurovascular development. Mechanisms are largely unknown and biomarkers for adverse outcomes ... -
Advances in MRI based radiation therapy - Bringing MRl-only and multiparametric methods towards clinical applications
MRI data have the advantage of being excellent in soft tissue contrast, therefore having an increasing imaging role in external radiation therapy (RT). Lately, attention has been directed towards MRI-only workflows, with ... -
Septoplasty-predicting the outcome
Septoplasty is one of the most common surgical procedures at ENT clinics around the world. The reason for undergoing a septoplasty is nasal airway obstruction (NAO) that does not respond to any other treatment. The most ... -
On ankle fractures
Ankle fractures range from simple avulsions to complex injuries and the treatment options are numerous. Sweden has no national guidelines regarding the management and treatment of ankle fractures, leaving these choices up ... -
Novel immunotherapies for metastatic uveal melanoma - From bench to clinical biomarkers
(2022-11-25)Immunotherapy has revolutionized cancer treatment, with durable long-term effects in a proportion of patients. However, in around half of these patients, there are little to no effects. Patients with metastatic uveal ... -
Studies of molecular features and novel prognostic biomarkers of cutaneous melanoma
(2022-11-22)Cutaneous malignant melanoma is a highly heterogeneous disease. Immunotherapy has revolutionized the treatment of stage IV disease and is now successfully administered as adjuvant treatment in stage III and soon in stage ... -
Aspects of decisions to withhold and withdraw life-sustaining treatment in intensive care
(2022-11-15)End-of-life decision-making is required when the patient no longer benefits from available treatment options and there is a need to redirect medical treatment goals from cure to palliative care. End-of-life decisions are ... -
Recovery after surgically treated distal radius fracture - Aspects of evaluation and rehabilitation
(2022-11-14)BACKGROUND A distal radius fracture (DRF) is a common injury, occurring in both genders and during the entire life span, although it is most common in elderly women. An uncomplicated fracture is treated with a cast, but ... -
Effects of nonlinear noise reduction algorithms on image quality in computed tomography systems. Evaluations using human observers and methods for assessing distortion
(2022-11-10)Many conventional radiological examinations have during the past decades been replaced by examinations performed on computed tomography (CT) systems. One reason is that a CT system, in contrast to a conventional X-ray ... -
Exploring mechanisms of insulin secretion regulators using C. elegans
(2022-11-09)Diabetes mellitus is a group of disorders characterized by disrupted glucose homeostasis. Diabetes is one of the most dangerous diseases worldwide since it affects currently more than 500 million people. The pathogenesis ... -
lntramuscular pressure in the lower leg - Studies on chronic exertional compartment syndrome and effects of external compression
(2022-11-04)This thesis on intramuscular pressure (IMP) in the lower leg is concerned with two topics. The first of these is external compression; more specifically, the effect of compression stockings (CS). There are conflicting data ... -
Coagulation in paediatric cardiac surgery
(2022-10-28)Background: Surgical correction of congenital heart defects has a profound effect on the coagulation of the patients during and immediately after surgery. The aim of this thesis was to increase the knowledge of this effect, ... -
Levosimendan vs. Milrinone: Early Renal and Hemodynamic Outcomes after lnfant Cardiac Surgery
(2022-10-25)Background: Myocardial and renal dysfunction are common after cardiac surgery in young children, which increases risk of complications and delayed recovery. Inodilators, such as milrinone and levosimendan, are frequently ... -
Acute kidney injury after cardiac surgery and heart transplantation - monitoring, prevention and treatment
(2022-10-14)Background: Acute kidney injury (AKI) is a common and serious complication after cardiac surgery and heart transplantation, leading to increased morbidity and mortality. To date, there are neither proven clinical real-time ... -
Evaluation of absorbed dose uncertainty in modulated radiotherapy plans
(2022-10-10)The purpose of this work was to develop and evaluate methods to meet the challenges of quality control (QC) for modulated radiotherapy plans. It was shown that nine of 15 intensity modulated radiotherapy (IMRT) plans, ... -
Liver Transplantation-associated Food Allergy and Eosinophilic Gastrointestinal Inflammation in Children - Clinical and Immunological Aspects
(2022-10-03)This thesis focuses on three recently described childhood-onset gastrointestinal disorders: liver transplantation-associated food allergy (LTFA), collagenous gastritis (CG) and eosinophilic esophagitis (EoE). Its aim was ... -
Contact Allergy to Propolis and Beeswax Occurrence, Diagnostics and Chemistry
(2022-10-03)Cosmetics, including biocosmetics and “natural” skin remedies are common causes of contact dermatitis. Two frequent ingredients in biocosmetics are beeswax and propolis, which are known causes of contact allergy. These ... -
The use of immunological biomarkers to improve individualization of postoperative radiotherapy in breast cancer
(2022-09-30)Radiotherapy (RT) forms the cornerstone of most curative breast cancer treatment due to its well-established risk-reducing effect on local recurrences at the population level. However, there is heterogeneity regarding ... -
Insights from combining Action Research and System Dynamics when facilitating change and improvement processes in healthcare
(2022-09-30)BACKGROUND Healthcare is a complex system with multi-professional staff and multiple patient care pathways. Time pressure and minimal margins for error makes it challenging to implement new policies or procedures, no ...
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