Doctoral Theses from Sahlgrenska Academy: Recent submissions
Visas titlar 21-40 av 2013
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Physicians' practices in sickness certification for common mental disorders - assessment of work capacity and communication with the patient's workplace
(2021-11-25)Physicians are key stakeholders in the sickness certification process. The first aim of this thesis was to examine physicians’ sickness certification practices from two perspectives: the assessment of work capacity and ... -
Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins
(2021-11-25)Aging entails loss of functionality and increased risk of death, even for unicellular organisms, such as the yeast Saccharomyces cerevisiae. On a cellular level, aging is accompanied by an accumulation of harmful aging ... -
Epithelial signatures in respiratory disease
(2021-11-25)The epithelium of the human airways protects us against harm and helps maintain immune homeostasis. In respiratory diseases such as asthma and COPD, the functions of the epithelium are altered and can cause or contribute to ... -
lnternalizing problems in childhood and adolescence: predictive, etiological, and neurodevelopmental aspects
(2021-11-25)Internalizing disorders such as anxiety and depressive disorders are common mental disorders in childhood and adolescence. They are characterized by disordered emotions and moods, causing emotional distress and impairment. ... -
On the use of radiography and radiation dose consideration in orthodontic treatment
(2021-11-25)The aims of this thesis were to analyse the use of radiography and radiation risk associated with orthodontic treatment. Study I measured absorbed doses to radiosensitive organs in the head and neck in an anthropomorphic ... -
FET fusion oncoproteins in sarcoma tumorigenesis - lnteractions with the SWI/SNF chromatin remodeling complex and epigenetic effects
(2021-11-23)The FET family of fusion oncoproteins containing the N-terminal of either FUS, EWSR1 or TAF15 together with a transcription factor partner is the characteristic oncogenic driver of more than 20 types of sarcoma and leukemia, ... -
The roles of osteoclasts and RUNX2 in the progression of prostate cancer bone metastases
(2021-11-23)Metastasis to the skeleton is the major cause of death from prostate cancer (PC). Patients with metastatic PC are treated with androgen deprivation therapy (ADT) to decrease testosterone levels and thereby inhibit further ... -
Prevention and treatment of experimental peri-implantitis
(2021-11-22)Peri-implantitis is a plaque-associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri-implant mucosa and progressive loss of supporting bone. The aims ... -
On factors associated with development of oral squamous cell carcinoma
(2021-11-18)Oral squamous cell carcinoma (OSCC) has severe impacts on the affected patient’s morbidity and mortality. Early detection of OSCC is of outmost importance to reduce morbidity and to improve patient survival. A significant ... -
A search for prognostic biomarkers in diffuse large B-cell lymphoma with proteomics and immunohistochemistry
(2021-11-18)Diffuse large B-cell lymphoma (DLBCL), the most common lymphoma in the Western world, can by gene expression profiling or immunohisto-chemistry (IHC), be divided into two subgroups according to its “cell-of-origin”. The ... -
Investigating ALK inhibitors alone or in combination as therapeutic options for ALK-positive neuroblastoma
(2021-11-16)Neuroblastoma (NBL) is the third most common pediatric cancer after leukemia and cranial tumours and accounts for around 15% of death in pediatric malignancy. NBL develops due to the poorly differentiated progenitor cells ... -
Development of a Prehospital Decision Support Tool - Optimisation of the prehospital triage of patients with chest pain
(2021-11-16)Background: Chest pain is one of the most common symptoms in patients contacting the emergency medical services (EMS). This large group consists of patients with disorders of various causes and severity. Prehospital risk ... -
Lumbar Disc Herniation Surgery - Novel Approaches, Timing and Outcomes
(2021-11-16)Lumbar Disc Herniation Surgery – Novel Approaches, Timing and Outcomes JOEL BECK Department of Orthopaedics, Institute of clinical sciences, Sahlgrenska academy, University of Gothenburg, Sweden, 2021 ABSTRACT BACKGROUND ... -
Breast cancer surgery - Aspects of patient-reported outcomes and physical activity
(2021-11-15)The aim of this thesis was to evaluate patient-reported outcomes (PROs) following breast cancer surgery using three different studies. Paper I examined breast-conserving surgery through an inframammary fold incision using ... -
Jejunal control of glucose homeostasis in the human body
(2021-11-15)Background: The prevalence of obesity and type-2 diabetes mellitus (T2DM) have risen dramatically over the last decades, and are major threats to the human health. Obesity, and also T2DM, is treated with lifestyle ... -
Word-finding difficulties in left hemisphere stroke, multiple sclerosis and Parkinson's disease - differences in symptom occurrence and effects of anomia treatment
(2021-11-11)Word-finding difficulties, or anomia, are a common symptom in various conditions affecting the brain, such as stroke, multiple sclerosis (MS) or Parkinson’s disease (PD). The aim of this thesis is twofold: (i) to increase ... -
Sagittal synostosis - surgical outcomes and long-term follow up
(2021-11-11)The overall aim of this thesis was to evaluate and compare surgical outcomes in patients with sagittal synostosis operated with the most commonly used surgical methods in Sweden: craniotomy combined with springs, pi-plasty, ... -
Experiences of living with cleft lip and palate - a gender perspective
(2021-11-10)The primary aim of this thesis was to investigate the influence of gender on the CL/P population with regard to treatment, self-reported appearance, psychosocial adjustment, and subjective experiences. Study I, a retrospective ... -
A meaningful work in a strained context - exploring midwives' work situation and professional role
(2021-11-09)Midwives report a challenging work situation globally with a work force shortage, which is a large challenge for health-care organisations and can influence midwives’ professional role. The overall aim of this thesis was ... -
Running-related injuries in recreational athletes.
(2021-11-09)Running as a form of physical activity continues to grow in popularity and is accompanied by a number of health benefits, but one of the greatest threats that challenge these benefits is running-related injuries. The overall ...