Doctoral Theses from Sahlgrenska Academy: Recent submissions
Now showing items 301-320 of 2013
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Intestinal preservation for transplantation: translational approaches
(2019-11-13)Background: Intestinal preservation injury (IPI) may result in various degrees of mucosal damage, which may later favor bacterial translocation, post-reperfusion syndrome, and upregulation of alloreactivity. Experimental ... -
Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action
(2019-11-13)Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis ... -
Cardiac lipids and their role in the diseased heart
(2019-11-13)Lipids play an essential role within the heart as they are involved in energy storage, membrane stability and signaling. Changes in cardiac lipid composition and utilization may thus have profound effects on cardiac ... -
Temporomandibular disorders in women—symptoms and signs in population-based studies
(2019-11-13)The overall aim of this thesis was to investigate symptoms and signs of temporomandibular disorders (TMD) and orofacial pain in the Swedish female population in relation to some other health factors. The thesis includes ... -
Regulation of gut IgA induction by helper T cells
(2019-11-12)The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to the outside world, it also functions as the most important portal of entry for many pathogens. T cell-dependent secretory immunoglobulin ... -
Hepatitis E virus in the virome of water and animals
(2019-11-12)This thesis was aimed to investigate viruses in different animals and water to get some understanding of viruses that disseminate into the environment. Next generation sequencing (NGS) was used to explore the virome from ... -
Bedömning i samverkan - en väg till remission vid schizofreni
(2019-11-11)Background: The process from assessment of symptoms and function to various efforts in psychiatric outpa-tient care is still a "black box". Our knowledge of the connection between processes in care and the patient's status ... -
Understanding the role of long non-coding RNAs in neuroblastoma development and progression
(2019-11-11)Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to ... -
Factors influencing outcome in patients with obstructive hypertrophic cardiomyopathy - Effects of pharmacotherapy, pacing and surgical myectomy
(2019-11-07)Background: Most studies on risk factors for disease-related mortality in hypertrophic cardiomyopathy (HCM) have emanated from specialized tertiary centres which are subject to possible referral bias. About one quarter of ... -
Patient Perspectives brought to the Fore for Diabetes Care: Descriptions as well as Development and Testing of the Diabetes Questionnaire
(2019-11-07)Aim: The overall aims were to describe perspectives of living with diabetes, to develop a patient-reported outcome and experience measure for the Swedish National Diabetes Register, and to initiate the evaluation of evidence ... -
Tonsil Surgery - Register Studies of Complications and Outcomes
(2019-11-07)Tonsillectomy is a commonly performed surgical procedure yet the evidence of the effect in patients with recurrent/chronic throat infections is unsatisfactory. Great variations exist in the reported rates of postoperative ... -
Cardiac abnormalities in chronic kidney disease
(2019-11-06)Chronic kidney disease (CKD) is a global health problem associated with increased risk of mortality and development of end-stage renal disease (ESRD). Cardiovascular diseases are the leading cause of morbidity and mortality ... -
Citrobacter rodentium and Escherichia coli interactions with mucus producing colonic epithelical cells
(2019-11-06)The epithelial cells together with the mucus layer protect the host from noxious luminal substances and pathogenic invasion. Pathogens have evolved numerous strategies to circumvent these barriers and mount infection. C. ... -
Gastrointestinal norovirus infections and the development of the next generation of mucosal vaccines
(2019-11-06)Human norovirus (HuNoV) is the causative agent of the winter vomiting disease and the leading cause of outbreaks of gastrointestinal infections across all settings and age groups in the world. The virus is highly contagious ... -
On detection, treatment and prevention of complications in paediatric cataract surgery
(2019-11-06)Purpose: To find and validate methods for diagnosis, treatment and prevention of complications in paediatric cataract surgery. Background: Cataract and glaucoma are major treatable blinding conditions in children. Surgery ... -
Energy metabolism and angiogenesis in atherosclerosis and cancer
(2019-10-30)Energy metabolism requires supply of glucose and oxygen. In atherosclerotic plaques and cancer tumors, there are local areas with mismatch in demand and supply of oxygen and nutrients. The resulting cellular energy imbalance ... -
Risk Factors and Predictors of Heart Failure: from Incidence to Prognosis
(2019-10-30)Background: Heart failure (HF) is a major public health problem affecting at least 26 million people worldwide and one of the leading causes of disability and death. Aims: To identify characteristics associated with ... -
The use of fibrinogen in cardiac surgery patients-clinical and experimental studies
(2019-10-30)BACKGROUND Cardiac surgery with cardiopulmonary bypass impairs hemostasis due to hemodilution and consumption of platelets and coagulation factors, such as fibrinogen. The aim of this thesis was to study the role of ... -
Estrogen receptor α and Bone – Posttranslational modifications and cell-specific deletion
(2019-10-30)Estrogen is involved in the regulation and development of reproductive organs. In addition, estrogen regulates several other organs including the skeleton, immune system, and adipose tissue. Estrogen treatment protects ... -
Next Generation Sequencing for Measurable Residual Disease Detection in Acute Myeloid Leukemia
(2019-10-30)Acute myeloid leukemia (AML) is the most common form of acute leukemia and generally associated with a poor prognosis. For both children and adults, the treatment is based on chemotherapy. Allogeneic hematopoietic stem ...