Doctoral Theses from Sahlgrenska Academy: Recent submissions
Now showing items 341-360 of 2013
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Studies of tibial fractures using the Swedish Fracture Register
(2019-09-13)This thesis has two topics. First, the creation and application of the Swedish Fracture Register (SFR) is described. Second, a series of studies of tibial fractures based on data from the SFR follows. Until the start ... -
Generalized anxiety disorder (GAD) and anxiety symptoms in older adults
(2019-09-11)Anxiety is a broad concept, difficult to detect and recognize. Expression may shift over the lifetime further complicating identification. Generalized Anxiety Disorder (GAD) is one of the most common anxiety disorders in ... -
Management and women's experiences of pregnancies lasting more than 41 gestational weeks
(2019-09-10)It is well known that the risks for complications of both the foetus and the mother increase in post-term pregnancy. To date, there is no uniform worldwide guideline for when to induce a pregnant woman who has passed her ... -
Tau fragments: role as biomarkers and in the pathogenesis of Alzheimer's disease and other tauopathies
(2019-09-10)Abstract Tau protein is physiologically expressed in neurons, where it is involved in microtubule assembly and stability. Tau functions are rigorously regulated by a series of modifications, e.g. phosphorylation and ... -
Candidatus Neoehrlichia mikurensis - a new agent of tick-borne infectious disease
(2019-09-06)“Candidatus Neoehrlichia mikurensis” (Ca. N. mikurensis) is a tick-borne bacterial pathogen that can cause disease particularly among immune compromised persons. This new infectious disease is called neoehrlichiosis. The ... -
Methotrexate and Risk of Cutaneous Melanoma
(2019-09-06)Methotrexate (MTX) is an anti-inflammatory and immunosuppressive drug commonly used to treat psoriasis, psoriatic arthritis and rheumatoid arthritis. Cutaneous malignant melanoma (CMM) is a common and dangerous type ... -
Biochemical markers in dementia - Exploring Swedish registry data and the human proteome
(2019-09-04)Cerebrospinal fluid (CSF) biomarkers of neurodegenerative diseases have a wide scope of applications in diagnostics, prognosis assessment, disease staging, treatment evaluation and more. In this PhD project we aimed to ... -
Work-related cardiovascular disease
(2019-09-02)The overall aim of this thesis was to study occupational risk factors for cardiovascular disease, particularly, occupational noise, job strain and shift work. Incidence of cardiovascular disease was analysed in a general ... -
Acute febrile illness in preschool children in Zanzibar - Infectious aetiologies, diagnosis and treatment
(2019-09-02)Background: A majority of the three million children in Africa that do not survive their fifth birthday die from infections that often start as a seemingly uncomplicated febrile illness. Primary health care workers ... -
Multimodal Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
(2019-08-30)Alzheimer’s disease (AD) is the most common form of dementia. AD has been linked to the aggregation of amyloid beta (Aβ) peptides into extracellular deposits, Aβ plaques. These are also found in cognitively unimpaired ... -
Generalized Joint Hypermobility and Specific Knee Laxity: Aspects of influence on the Anterior Cruciate Ligament Injured Knee
(2019-08-19)Injury to the anterior cruciate ligament (ACL) is one of the most serious sports-related injuries, with significant short- and long-term morbidity. Generalized joint hypermobility (GJH) and specific knee laxity are factors ... -
Radiation-induced dysphagia in head and neck cancer - risk structures and methodological aspects
(2019-08-19)Background/Aims: Swallowing difficulties are common after radiation therapy (RT) in head and neck cancer (HNC). The overall aim of this thesis was to address radiation-induced late dysphagia with regard to investigating ... -
Statins, Lipids, and Mutations: Consequences for the Heart and Immune System
(2019-08-14)CAAX proteins are a group of proteins that undergo a three-step protein maturation process that renders the proteins carboxyl-terminus hydrophobic and prone to localize to cellular membranes, where they have their primary ... -
Chest Tomosynthesis for Detection and Surveillance of Pulmonary Pathology. Studies on Cystic Fibrosis and Solid Pulmonary Nodules
(2019-06-17)Introduction: Digital tomosynthesis (DTS) is a relatively new imaging modality in thoracic imaging. The technique is based on the equipment of conventional radiography, upgraded with a moving tube that enables separation ... -
Preclinical Studies for Cryoprevention of Oral Mucositis
(2019-05-24)Oral mucositis (OM) is a debilitating adverse effect, with a prevalence of up to 80% in patients with cancer who are conditioned with high-dose chemotherapy prior to hematopoietic stem cell transplantation. In its mildest ... -
Molecular perspectives on glomerular cell physiology in chronic kidney disease
(2019-05-24)Glomerulonephritis is one of the most common causes of chronic kidney disease (CKD) in the world. Recent establishment of guidelines for classification of CKD in five stages has led to increased awareness of the risks of ... -
Colorectal Cancer - Evaluation of MMP as a prognostic marker and a model for peritoneal response
(2019-05-24)Background : There are about 6600 patients diagnosed with colorectal cancer in Sweden each year. Survival rates vary with cancer stage at diagnosis. The main treatment is surgery together with, in some cases, oncological ... -
On cognition and personality in bipolar disorder
(2019-05-24)Even though the hallmark of bipolar disorder is recurrent episodes of elevated or depressed mood, mounting evidence suggests that cognitive impairment is a prominent characteristic of bipolar disorder. The heterogeneity ... -
On Neuroimmunology and Brain Function: Experimental and Clinical Studies
(2019-05-23)The immune system has been implicated in the mechanisms underlying many psychiatric disorders. Immune mediators are expressed in the central nervous system (CNS) not only in response to harmful stimuli, but also in a ... -
CSF biomarkers in idiopathic normal pressure hydrocephalus- Diagnostics and pathophysiology
(2019-05-23)Idiopathic normal pressure hydrocephalus (iNPH) is a disease of the elderly with enlarged ventricles despite a normal CSF pressure. Clinically, iNPH presents with gait- and balance disturbances, cognitive decline and ...