Doctoral Theses / Doktorsavhandlingar Institutionen för medicin
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Health economic aspects of stroke: stroke prevention and effects on spouses' healthcare consumption and income
(2023-01-23)The overall aim of this thesis was to investigate two health economic aspects of stroke: (i) the clinical and cost-effectiveness of stroke prevention with left atrial appendage occlusion (LAAO) among persons with atrial ... -
Factors of importance for work productivity in Irritable Bowel Syndrome
Disorders of gut-brain interaction (DGBI) are highly prevalent in the general population, and irritable bowel syndrome (IBS) is one of the most common DBGI. Having IBS, and many of the DGBI, can impact work life. However, ... -
Pain, gender norms and psychosocial resources. A critical appraisal of taken for granted ideas on men and women with pain
Background: Gender norms concerning pain are important to consider as they might lead to unequal treatment of men and women in health care. Aim: The overall aim of this thesis was to explore and describe gender norms ... -
Endogenous sex hormones and cardiometabolic risk factors – population-based studies within the Skaraborg Project
(2022-12-21)Cardiovascular diseases are the major contributors to mortality in Sweden and globally. Men have a higher incidence of cardiovascular diseases compared to women, until women reach the menopause. Levels of sex hormones ... -
Understanding the genetic architecture of fatty liver disease
(2022-11-29)Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease, ranging from simple steatosis to more severe conditions, namely non-alcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, ... -
Female sex hormones and health outcomes in women with specific focus on asthma
(2022-11-25)In humans, gender differences exist across a wide spectrum of diseases. For instance, women are more likely to develop Sjogren’s syndrome, systemic lupus erythematosus, and autoimmune thyroid disease compared to men. On ... -
Human stem cell-based in vitro model of cardiac hypertrophy
(2022-11-18)Cardiac hypertrophy is an important and independent risk factor for the development of cardiomyopathy that may lead to heart failure. To accelerate the development of new and improved treatment options, relevant disease ... -
Gout - epidemiological studies on work outcomes, airborne risk factors and treatment patterns
(2022-11-10)The overall aim of the thesis was to describe the contemporary epidemiology and use of urate-lowering therapy (ULT) for gout in the Swedish region of Dalarna, to describe the impact of the disease with regard to sickness ... -
Catching broken hearts - Electrocardiography and in-hospital outcome in Takotsubo syndrome versus ST elevation myocardial infarction
(2022-11-10)BACKGROUND AND AIMS: Takotsubo syndrome (TS) and acute myocardial infarction (AMI) have similar symptoms, non-invasive test results and complications. Whereas AMI is caused by cardiac ischemia, the pathophysiology of TS ... -
On kidney dysfunction in advanced liver disease
(2022-11-10)Aims: The overall aim of this thesis was to characterize factors affecting kidney function in advanced liver disease as well as after liver transplantation and to further understand the complex interaction between acute ... -
Cardiopulmonary bypass: Clinical studies in cardiac surgery patients
(2022-11-01)BACKGROUND: Cardiopulmonary bypass (CPB) is necessary to facilitate most cardiac operations. Although the vast majority of patients tolerate CPB physiology in conjunction with cardiac surgery well, there is risks of adverse ... -
Heart failure with reduced ejection fraction of ischaemic and non-ischaemic aetiology – Clinical characteristics, prognosis and factors associated with outcome
(2022-10-28)BACKGROUND: Ischaemic heart disease (IHD) is common in heart failure (HF) and is often considered to infer a worse prognosis. Following treatment improvements and the increased survival in both IHD and HF, patients are ... -
Physical activity and exercise in patients with intermittent claudication
(2022-09-26)Introduction. Supervised exercise is a guideline recommendation in patients with intermittent claudication (IC). As the availability of supervised exercise varies, interest has turned to the more accessible home-based ... -
Vaccine responses after chemotherapy or stem cell transplantation in patients with hematological malignancies
(2022-09-22)The prevention of infections in patients with hematological malignancies is important given the inherent immune deficiency associated with these diseases and the immunosuppressive effects of treatment. This thesis investigated ... -
Mechanical circulatory support in advanced heart failure - patient selection, treatment strategies and outcomes
(2022-09-19)Background: Heart transplantation (HTx) remains the major treatment option for selected patients with end-stage heart failure. In hemodynamically unstable patients, or when there is a considerable risk of deterioration ... -
The economics of a silent pandemic - A health economic analysis of antibiotic resistance in Sweden
(2022-08-16)The overall aim of this thesis was to analyze the health economic consequences of antibiotic resistance in Sweden, and to assess the implications of methodological assumptions related to measuring health in health economic ... -
Peripheral airway function assessed by inert gas washout and impulse oscillometry
(2022-08-15)Small (peripheral) airways play a key role in asthma. Despite this is lung function tests for assessing small airway function not included in the routine asthma management. Undetected small airway dysfunction (SAD) may ... -
Free Fatty Acid Receptor 2 - A G protein coupled receptor with unique signaling properties in neutrophils
(2022-08-15)The overall aim of the PhD thesis was to determine the role of neutrophil pattern recognition receptors in the initiation and resolution of inflammatory processes. Neutrophil pattern recognition receptors such as the formyl ... -
Non-functioning pituitary adenomas and hypopituitarism - studies on morbidity and mortality
(2022-06-15)Background and aims: Hypopituitarism is most commonly caused by benign pituitary tumors, often resulting in insidious symptoms that develop over a long time. Due to either a mass effect exerted by the tumor, or due to the ... -
The role of galectin-1 in type 2 diabetes. Clinical and experimental studies
(2022-05-27)Aim: The purpose of this thesis was to identify a new agent in the subcutaneous adipose tissue and assess its clinical potential in the context of type 2 diabetes. Study I: Through a combination of microdialysis and ...
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