Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
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Surgical treatment strategies of chronic subdural hematoma
(2022-12-05)Background: A subdural collection of old blood is called a chronic subdural hematoma (cSDH). A cSDH of sufficient volume becomes symptomatic and neurosurgical evacuation is then necessary. The recurrence rate (5-21%) after ... -
Acquired epilepsy in Multiple sclerosis: a nationwide register-based investigation into prognosis and treatment
(2022-11-22)The prevalence of epilepsy in persons with multiple sclerosis (MS) is thrice that of the general population. The association between epilepsy and MS prognosis and its management are however largely unknown. The prevalence ... -
Oral eflornithine treatment of late-stage human African trypanosomiasis
(2022-11-21)Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African ... -
A Multimodal Approach toward the Biological Categorization of Autism - Development of Theoretical Models, Classification Methods, and Biomarkers
(2022-11-18)Autism Spectrum Disorder (ASD) is an umbrella term for a group of neurodevelopmental disorders (NDD) which are behaviorally defined by the presence of difficulties with social communication, and behavioral rigidity and ... -
A standardised follow-up model to support people after stroke -Development and application using the post-stroke checklist
(2022-10-21)Objectives: The need for a standardised follow-up has increased, as more people survive and live with stroke-related consequences. The Swedish national stroke guidelines recommend the use of the post-stroke checklist (PSC) ... -
Dietary patterns among older adults - With focus on dementia and related biomarkers
(2022-10-18)Background and aim: Diet is a lifestyle factor that can influence healthy ageing and the risk of developing dementia. Studies investigating dietary patterns among older adults in relation to dementia, and dementia-related ... -
Comorbidity of inflammatory diseases in the lower urinary tract - the link between chronic prostatitis and bladder dysfunction
(2022-10-18)Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common disease in men that currently lacks satisfactory pharmacological treatment alternatives. The aim of this thesis was to investigate the effects of CP/CPPS ... -
DNA methylation profiling of CNS tumors; implications for clinical diagnostics
(2022-10-05)Diffuse gliomas and meningiomas are the most common primary tumors of the central nervous system (CNS) in adults and these tumors cause significant morbidity and mortality worldwide. Deregulation of the epigenetic mechanisms, ... -
Deriving biomarkers from computed tomography using deep learning
(2022-09-23)X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are widely used structural neuroimaging modalities. For brain atrophy assessment and volumetric quantification using automated methods, MRI is the preferred ... -
Children with severe/profound intellectual and multiple disabilities - characteristics and communication interventions
(2022-09-20)Children with severe or profound intellectual and multiple disabilities (S/PIMD) communicate presymbolically and need support in all aspects of daily life. Communication intervention studies are scarce, and so is research ... -
Exploring person-centered care in acute psychosis care settings. Findings from the Person-Centered Psychosis Care project.
(2022-09-16)Many persons with psychotic disorders are in need of inpatient care at some point in time. The inpatient setting is suggested to need reform to better deliver recovery-oriented care and align with legislation emphasizing ... -
Investigations into the role of Epstein-Barr virus in the pathogenesis of multiple sclerosis
(2022-09-08)Epstein-Barr virus (EBV) infection may be a prerequisite for the development of MS. Virtually all MS patients have antibodies to Epstein Barr virus nuclear antigen 1 (EBNA1), compared to 90-95% of healthy individuals. ... -
Neurodevelopmental disorders (ESSENCE): Early detection and outcome in adulthood
(2022-09-02)Objectives: Examine outcomes in adulthood for a group of individuals diagnosed with fetal alcohol spectrum disorders (FASD), and for another group during childhood diagnosed with attention-deficit/ hyperactivity disorder ... -
The neuromodulatory effect of extracellular ions in the central nervous system
(2022-08-23)Neurons are the cells that send and receive signals in the central nervous system. Neuronal signaling is the base for all the complex tasks the human brain is capable of, from the detection of a smell to the composition ... -
CSF biomarker panels. Focus on synaptic pathology
(2022-08-18)Fluid biomarkers of neuropathological features are important clinical tools in diagnostics and patient monitoring of neurodegenerative diseases. For the most prevalent cause of dementia, Alzheimer’s disease (AD), several ... -
Perinatal Staphylococcus epidermidis infection and the immature brain: a neuroinflammatory link
(2022-05-27)Preterm birth and its associated complications are among the most serious global health issues that modern society faces. Due to the prolonged medical care and immature immune system, preterm infants have a higher ... -
lnvestigating intestinal smooth muscle dysfunction in the 6-OHDA rat model of Parkinson's disease
(2022-05-27)The neurodegenerative progression of the nigrostriatal pathway in Parkinson’s disease (PD) entails the appearance of motor and nonmotor symptoms. Nonmotor symptoms are common, having a negative impact on the quality of ... -
Dopaminergic lnterference for Treatment of Schizophrenia and Alcohol Use Disorder - an experimental study in rats
(2022-05-27)The neurotransmitter dopamine is involved in several different physiological functions as well as pathological conditions. Two conditions that have been suggested to be related to a low dopaminergic tone in the ventral ... -
Cerebral Venous Thrombosis - Complications and Outcomes
(2022-05-17)Cerebral venous thrombosis (CVT) is a relatively rare cause of stroke, which predominantly affects working-aged adults and particularly women. The clinical course is highly miscellaneous. Data from large cohorts are scarce ... -
Chronic Achilles Tendon Rupture - Perspectives on outcomes after surgical treatment and rehabilitation
(2022-05-04)Chronic Achilles tendon rupture (CATR) is a rupture of the Achilles tendon for which adequate diagnosis and treatment has been delayed after index injury. In this thesis defined as 4 weeks or more. The delay is commonly ...
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