patienten att ta ansvar för sin hälsa efter individuell förmåga. Studien understryker vikten av en strukturerad uppföljning efter barncancer.

Abstract

Introduction: Late-life depression and dementia are two common diseases in later life, and it is not unusual for them to co-occur. Previous research has suggested that they might share genes. The results, however, have been contradictive. Since the relationship between Alzheimer´s disease (AD) and late-life depression is unresolved, genes for general cognitive ability might be a clue to resolve the cognitive connection to depression. Aim: The primary aim of this study is to investigate if a polygenic risk score for Alzheimer´s disease is associated with depression among individuals aged 70-109 years in a populationbased sample in Gothenburg. The secondary aim is to investigate if a polygenic risk score for cognitive performance (based on genetic variants associated with cognition in individuals at 30 years of age) is associated with depression in the same population. Method: The study sample was comprised of 3054 participants, from four cohorts from the Gothenburg Cohort Studies. For the statistical analysis participants data was included based on genotype data and data of depression and was excluded based on data of dementia. Six PRS were analyzed with general estimating equation to see if they were associated with latelife depression. Results: Statistical analysis with generalized estimating equation, did not show any association with polygenic risk score for AD and depression. However, for major depressive disorder and PRS for cognition, there was a significant association. Conclusions: In this study there was no evidence that depression has an association with a PRS for AD. However, a significant association was found between major depression and PRS for cognitive performance. Due to the relatively small study sample future research is required to strengthen this association.