Sahlgrenska Academy / Sahlgrenska akademin: Recent submissions
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Novel immunotherapies for metastatic melanoma - from mouse models towards clinical trials
(2019-12-06)Immunotherapies including checkpoint blockade and adoptive T cell transfer (ACT) show great promise for the treatment of melanoma, with long-term effects in some patients. However, around half of the patients with metastatic ... -
Patients and Staff in the Hybrid Operating Room: Experiences and Challenges
(2019-11-29)The hybrid operating room (OR), which combines a traditional OR with a radiological intervention room, is one example of the technical advancements within hospitals. In a hybrid OR, the staff have to manage the technique ... -
Development of methods and strategies for optimisation of x-ray examinations
(2019-11-29)The overall aim of the work presented in this thesis was to develop methods and strategies for the optimisation process prescribed by legal authorities for medical X-ray imaging. This overall aim was divided into four ... -
OVULATION: Intra-ovarian mechanisms
(2019-11-28)Background: Ovulation is the central biological process involved in the menstrual cycle of women. Specifically, ovulation involves the tissue remodelling of the preovulatory follicle to achieve the rupture of the exterior ... -
Experiencing life as migrants living with HIV in Sweden
(2019-11-27)The focus of this thesis is on the life situation of migrants living with HIV in Sweden. The overall aim of this thesis was to explore the knowledge of HIV-positive migrants’ life situation in Sweden, with a focus on health ... -
Cell cycle regulation in cancer: A noncoding perspective
(2019-11-26)The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. ... -
Exercise in older adults with rheumatoid arthritis - a person-centred approach
(2019-11-20)Physical activity and exercise are well known to enhance health and are recommended as part of the management of rheumatoid arthritis (RA). However, the level of physical activity among older adults with RA is found to be ... -
Heart failure epidemiology with emphasis on young adults
(2019-11-20)Background: Heart failure (HF) is a major health problem worldwide with exponentially increasing incidence with age and the majority of patients being elderly. In recent years, an increase in hospitalization and prevalence ... -
Spinal mobility, muscle strength and function in patients with idiopathic scoliosis. Different aspects on long term outcome
(2019-11-19)Introduction: The long-term physical function outcome in patients treated for idiopathic scoliosis (IS) during childhood and adolescence has not been fully explored. In addition, there is a lack of studies where different ... -
Towards restoring intestinal health after pelvic radiotherapy - Lessons from dietary fiber intervention in a novel mouse model
(2019-11-18)Patients who have cancer in the pelvic region are at risk of developing gastrointestinal symptoms for weeks, months, or even years after receiving radiotherapy. These symptoms are triggered due to unwanted radiation-induced ... -
Health-Related Quality of Life and Growth Hormone Treatment
(2019-11-18)Introduction Growth Hormone (GH) is used to increase height in Turner Syndrome (TS), the most common sex-chromosome aberration in women. GH is also beneficial for bone mass. However, little is known about how GH treatment ... -
The Swedish Infant High-grade Reflux Trial - and a Focus group study of parents’ experiences
(2019-11-18)Background: Vesicoureteral reflux (VUR) is a pathological back-flow of urine from the bladder to the ureter and renal pelvis. VUR is associated with an increased risk of urinary tract infections (UTI) and renal damages. ... -
Taurine and dopamine-related effects of ethanol. An experimental study in rodents
(2019-11-18)The reinforcing properties of alcohol (ethanol) are associated with activation of the mesolimbic dopamine system and the concomitant increase in dopamine in the nucleus accumbens (nAc). Changes in this system are thought ... -
Body mass index and mental health in young people - predictors of early heart failure and cardiomyopathy
(2019-11-18)Heart failure among young people is rare, but in contrast to decreasing incidence rates overall, recent studies have found increasing rates among the young over the last decades. Concomitantly, cardiomyopathies, which ... -
In vitro models of the blood brain-barrier using iPSC-derived cells
(2019-11-18)The blood-brain barrier (BBB) constitutes the interface between the blood and the brain tissue. Its primary function is to maintain the tightly controlled microenvironment of the brain. Models of the BBB are useful for ... -
Intestinal preservation for transplantation: translational approaches
(2019-11-13)Background: Intestinal preservation injury (IPI) may result in various degrees of mucosal damage, which may later favor bacterial translocation, post-reperfusion syndrome, and upregulation of alloreactivity. Experimental ... -
Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action
(2019-11-13)Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis ... -
Cardiac lipids and their role in the diseased heart
(2019-11-13)Lipids play an essential role within the heart as they are involved in energy storage, membrane stability and signaling. Changes in cardiac lipid composition and utilization may thus have profound effects on cardiac ... -
Temporomandibular disorders in women—symptoms and signs in population-based studies
(2019-11-13)The overall aim of this thesis was to investigate symptoms and signs of temporomandibular disorders (TMD) and orofacial pain in the Swedish female population in relation to some other health factors. The thesis includes ... -
Regulation of gut IgA induction by helper T cells
(2019-11-12)The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to the outside world, it also functions as the most important portal of entry for many pathogens. T cell-dependent secretory immunoglobulin ...