Sahlgrenska Academy / Sahlgrenska akademin: Recent submissions
Now showing items 441-460 of 2677
-
Outcome of Graves disease
(2020-02-05)Graves' disease (GD) is an autoimmune condition with elevated thyroid hormone levels and symptoms suggesting an affected brain. These symptoms often resolve with treatment but, for some patients, GD results in a long period ... -
Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials
(2020-01-30)Immunotherapy with PD-1 inhibitors has transformed the treatment of met-astatic cutaneous mela- noma, and can lead to complete and durable responses in a proportion of patients. However, in around half of the patients, the ... -
Health-economic evaluations of person-centred care
(2020-01-28)Person-centred care aims at making the individual partake in the healthcare decisionmaking and at supporting individual health management. This stands in contrast to usual care, which typically has more focus on the ... -
Febrile Seizures and associated neurodevelopmental disorder
(2020-01-22)Background: Febrile seizures (FS) are common in young children. There is a lack of knowledge about possible associations between FS and the child’s cognitive and behavioural development. Aim: Gain further insight into the ... -
The balancing act of living with symptoms. Patient-reported data and quality of care during and after treatment with proton beam therapy in patients with brain tumors
(2020-01-21)is thesis focuses on patients with primary brain tumors undergoing proton beam therapy (PBT) and the consequences of the treatment. Quality of care (QoC) in a recently established clinic in Sweden was also evaluated. ... -
On the role of genetic variation and epigenetics in hemostatic gene regulation
(2020-01-17)Many genetic variants have been identified to associate with circulating levels of hemostatic proteins and with thrombotic or hemorrhagic disorders. However, the underlying molecular mechanisms remain largely unknown. ... -
Perspectives on urban wastewater as a source of microbial pollution
(2020-01-17)Wastewater treatment plants are important links for dissemination of intestinal bacteria into surface waters. In this study, twelve mallards were exposed to treated wastewater for a period of 55 days. Faecal samples were ... -
Radiological and Clinical Changes in Idiopathic Normal Pressure Hydrocephalus: MRI, Vascular factors and Clinical Symptoms as Markers of Pathophysiology and Prognosis
(2020-01-15)Idiopathic normal pressure hydrocephalus (iNPH) is a treatable, neurological disorder affecting the elderly population causing gait, balance, cognitive and micturition impairments. Treatment results in a clinical improvement ... -
Epidemiological Aspects on Assessing and Treating Dyslipidemia in Type 1 Diabetes
(2020-01-08)Background: Cardiovascular disease (CVD) is a major cause of shortened longevity in individuals with type 1 diabetes. Dyslipidemia is one of the important modifiable risk factors. Aims: To investigate different aspects ... -
Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury
(2020-01-07)Perinatal complications such as asphyxia can cause brain injuries that are often associated with subsequent neurological deficits. The mechanisms of perinatal brain injury are not fully understood, but mitochondria play a ... -
Pain in Osteoarthritic Joints: Biological Signaling and 3D Models based on Imaging
(2019-12-19)Osteoarthritis (OA) is the most common joint disease, causing disability in middle-aged and elderly patients worldwide and imposing a huge socioeconomic burden. OA of the knee joint is a major cause of joint pain and, along ... -
Hepatitis B virus RNA in serum and liver tissue - quantification using digital PCR
(2019-12-19)Hepatitis B virus (HBV) infection is a global health issue that is responsible for approximately 900,000 deaths each year, by inducing liver cirrhosis and hepatocellular carcinoma (HCC). A few markers are used to classify ... -
Strain echocardiography in cardiac surgery - studies on the effects of loading conditions and inotropic agents on myocardial contraction and relaxation
(2019-12-19)Background: Although reductions in myocardial contractility and relaxation are key compo-nents in heart failure (HF), assessment of them is difficult, as clinical measurements deal with a net effect of myocardial contractility, ... -
Inflammatorisk tarmsjukdom (IBD) i Ronneby
(Arbets- och miljömedicin, Göteborgs universitet, 2019-12-16)I december 2013 upptäcktes höga halter av högfluorerade ämnen (så kallade PFAS) i ett vattenverk, som försörjde ⅓ av hushållen i Ronneby kommun med dricksvatten. För att undersöka om PFAS-föroreningen har lett till en ökad ... -
Sömnstörning av stomljud från tågtrafik i tunnel
(Arbets- och miljömedicin, Göteborgs universitet, 2019-10-28)Denna rapport redovisar översiktligt resultaten ifrån forskningsprojektet ”Sömnstörning av stomljud från tågtrafik”. Projektet finansierades av Trafikverket, och pågick under perioden 2016 – 2018. Under projektets gång ... -
En rapport om studiemiljö, stress och hälsa bland Sahlgrenska akademins studenter
(Arbets- och miljömedicin, Göteborgs universitet, 2017-10-02)Rapporter från både Göteborgs universitets Akademihälsa och Sahlgrenska akademin Studentkår har uppmärksammat en hög förekomst av överbelastning och psykisk ohälsa bland studenter vid Sahlgrenska akademin. Därför beslöt ... -
Life is doing. Facilitators and hindrances for occupational performance in adults with cerebral palsy - including methods of intervention
(2019-12-12)Introduction: Occupational performance is a complex process which poses difficulties to persons with CP even where they have relatively good motor function. Aim: To explore and describe the perception of occupational ... -
Changes in writing processes caused by post-stroke aphasia or low-grade glioma
(2019-12-11)Background: Writing is a cognitively and linguistically complex task, therefore sensitive to impairment caused by the presence and surgical removal of low-grade glioma or presence of post-stroke aphasia. Purposes: The ... -
Genome-wide epigenetic profiling of B cell leukemia and lymphoma
(2019-12-06)Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, ... -
Central actions of glucagon-like peptide-1 on food intake and reward: Novel neurological targets and sex divergent effects
(2019-12-06)Obesity is one of the biggest health risks of our society; however, treatment options are sparse and often result in suboptimal weight-loss. The glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist liraglutide was ...