Sahlgrenska Academy / Sahlgrenska akademin: Recent submissions
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Regenerative effects of mesenchymal stem cell-derived exosomes
(2019-02-06)Mesenchymal stem cells (MSCs) play pivotal roles for bone regeneration by virtue of their osteogenic differentiation ability and immunomodulatory capacity. Recently, secretion of exosomes/extracellular vesicles (EVs) has ... -
Mean systemic filling pressure - from Guyton to the ICU, and back again
(2019-02-01)Introduction: Mean systemic filling pressure (MSFP) is the equilibrated vascular pressure at zero flow. Venous return (VR) driving pressure (VRdP) is the difference between MSFP and right atrial pressure (RAP). In clinical ... -
On the Effects of Serotonin Reuptake Inhibitors in Major Depression
(2019-01-25)This thesis focuses on the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) and how these are reflected by the Hamilton Depression Rating Scale (HDRS). To this end, we have assembled a large data ... -
Glucagon-like peptide-1 and alcohol-mediated behaviors in rodents
(2019-01-18)Alcohol use disorder (AUD) is a serious cause of morbidity and mortality. However, due to the limited efficacy of existing pharmacotherapies, further investigations of potential neurochemical targets are required to define ... -
Perceived burden, lived experiences and experiences of learning processes and illness management in parents of children with severe or moderate haemophilia
(2019-01-18)Haemophilia is a complex condition to manage, especially for parents of newly diagnosed children, and the illness affects the whole family. The parents are deeply involved in the child’s treatment, as they frequently have ... -
Aspects of cost-effectiveness and feasibility of implementations for care of depressed persons in primary care - internet-based treatment and care manager organisation
(2019-01-18)Background: Depression is a major source of human suffering and a growing challenge for societies worldwide. The lion’s share of depressed persons in Sweden are diagnosed and treated in primary care. There is an urgent ... -
Early closure of a temporary ileostomy after rectal resection for cancer
(2019-01-16)A temporary ileostomy may reduce symptoms of anastomotic leakage after rectal resection for cancer. However, the stoma itself is associated with morbidity and early closure may reduce these symptoms. The aim of this thesis, ... -
Sexuality in women living with HIV
(2019-01-11)The overall aim was to investigate different aspects of sexuality in women living with HIV in Sweden. Study I was a meta-synthesis of 18 qualitative studies describing experiences of sexuality and reproduction in women ... -
Outcome Measures of Functioning and Physical Activity in Patients with Low Back Pain - Exemplified in Patients Who Undergo Lumbar Fusion Surgery
(2019-01-09)INTRODUCTION: Chronic low back pain (LBP) can negatively affect health in terms of disability and decreased levels of functioning and physical activity. Chronic LBP due to degenerative disc disease (DDD) is a subgroup ... -
Computational exploration of cancer genomes
(2019-01-09)Cancer evolves due to changes in DNA that give a cell an advantage at the expense of the remaining organism. These alterations range from individual base substitutions to broad losses or duplications of chromosomal material. ... -
Mesh-Based Immediate Breast Reconstruction. Complicantions and long-term results
(2019-01-09)There are few high-quality studies evaluating use of meshes in implant-based immediate breast reconstruction (IBR). This thesis analyzed current evidence of matrices and compared outcomes from the use of biological or ... -
Tonsil Surgery, studies on surgical methods and postoperative haemorrhage
(2019-01-07)Tonsil surgery is one of the most common surgical procedures in the world, with about 13,500 operations performed annually in Sweden. Sleep-disordered breathing in children and infection-related problems are the two most ... -
Advanced renal cell carcinoma - The role of orellanine and associated therapeutic challenges
(2018-12-20)Orellanine is a fungal nephrotoxin selectively toxic to the human tubular epithelial cells (HTEC) of the kidney nephrons leading to kidney failure. Patients treated with renal replacement therapy after orellanine poisoning ... -
Androgen receptor signaling mechanisms in bone
(2018-12-13)Osteoporosis is a common age-related disease that increases the risk of fractures. Androgens are crucial for bone health in males. Although a substantial part of the effects of androgens on the skeleton is mediated via ... -
Molecular Control of Organogenesis, Cell Fate Specification and Cell Differentiation: Genetic and Experimental Studies in the Mouse
(2018-12-13)Deciphering the mechanisms controlling normal development sheds light onto the etiopathogenesis of congenital malformations and diseases, and knowledge of the expression patterns of proteins and/or their encoding genes is ... -
Person-centred prehabilitation program to improve functioning
(2018-12-13)Introduction: Low back pain is a frequently reported symptom and has turned into a global problem. For people with severe chronic low back pain, spinal fusion surgery can be a treatment option. The outcome of fusion ... -
Let’s stay in touch! Remote communication for people with communicative and cognitive disabilities
(2018-12-13)Introduction: Being able to use remote communication through digital channels is a prerequisite for participation in contemporary society, but some people have difficulties in accessing it. Aim: The overall aim was to ... -
Prostate Cancer Screening: Outcomes and Risk Prediction
(2018-12-12)Prostate Cancer Screening: Outcomes and Risk Prediction Maria Frånlund, MD Department of Urology, Institute of Clinical Sciences Sahlgrenska Academy at University of Gothenburg, Sweden ABSTRACT The Göteborg Randomized ... -
The Role of Estrogen Receptor α Signaling in the Regulation of Bone Mass
(2018-12-06)Estrogens are major regulators of skeletal growth and maintenance in both females and males. Estrogen receptor α (ERα) is the main mediator of estrogenic effects in bone. Thus, estrogen signaling via ERα is a target for ... -
Brain-Gut Interactions in Irritable Bowel Syndrome (IBS)
(2018-12-04)Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction defined by recurrent and longstanding abdominal pain and disturbed bowel habits. This thesis aims to deepen the knowledge about aberrant visceral ...