Sahlgrenska Academy / Sahlgrenska akademin: Recent submissions
Now showing items 381-400 of 2677
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On Cyclodeviation - Strategies for Investigation, Management and quality of Life
(2020-06-04)Introduction: Cyclodeviation is a form of strabismus that is not externally visible. It is measured subjectively and in degrees, as incyclotorsion or excyclotorsion. The perception of subjective tilting does not always ... -
Aspects on the use of slowly degradable mesh in inguinal hernia surgery
(2020-06-04)Background: Synthetic non-degradable mesh used in inguinal hernia surgery can cause chronic inflammation, which in turn can lead to chronic post-operative pain (CPP). Theoretically, a degradable mesh could reduce the risk ... -
Obesity, Weight Loss and Cardiovascular Risk
(2020-05-26)Background: The global prevalence of obesity is on the rise, contributing to increased incidence and prevalence of cardiovascular morbidity and mortality. Obesity has adverse effects on cardiac structure and function, ... -
The impact of signaling factors on intervertebral disc degeneration and regeneration - studies on disc and mesenchymal stem cells from chronic low back pain patients
(2020-05-19)INTRODUCTION: Chronic low back pain (LBP) is associated with degeneration of the intervertebral discs (IVDs). Increased expressions of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and matrix metalloproteinases ... -
Aspects of infection and leukemia in Rwanda
(2020-05-19)A first part of this thesis addressed the potential impact of variants of genes encoding interferon-λ4, which is a cytokine that participates in protection against pathogens at epithelial surfaces, for the resolution of ... -
Shedding light on cognitive control
(2020-05-18)This thesis aimed to investigate the ability to adjust cognitive processes and behavior, i.e., cognitive control, and its related functional activity in the cortex. The optical imaging technique functional near-infrared ... -
On translucent yttria stabilized zirconia ceramics: Mechanical considerations, phase transformation and cement choices
(2020-05-18)New zirconia formulations (4Y and 5Y-zirconias) have been introduced for prosthodontic therapy and are commercialized as “translucent” zirconias. No clinical information providing their survival rates or complications has ... -
Development of MALDI Mass Spectrometry Imaging Methods for Probing Spatial Lipid Biochemistry of Amyloid Plaques in Alzheimer's Disease
(2020-05-18)Alzheimer’s disease (AD) is the most prevalent cause of neurodegenerative dementia. Aggregation of amyloid β (Aβ) peptides into extracellular Aβ plaques is one of the major neuropathological features of AD. However, Aloysius ... -
The effect of intra-abdominal local anaesthetics following major gynaecological surgery. Clinical and experimental studies
(2020-05-18)Background: Local anaesthetics (LA), in addition to inhibition of pain signalling, also have anti-inflammatory properties. In vitro studies have demonstrated anti-proliferative and cytotoxic effect of LAs on cancer cells ... -
Epidemiology of viral respiratory infections with focus on in-hospital influenza transmission
(2020-05-18)Human Rhinoviruses (HRV) and influenza viruses are respiratory pathogens which represent a major global disease burden. Healthcare-associated infections (HCAI) are increasingly recognized as a public health concern, but ... -
Biomarkers in mid-trimester amniotic fluid in relation to gestational duration and spontaneous preterm delivery
(2020-05-15)Background: The biological mechanisms and physiological pathways of pregnancy maintenance and timing of delivery are complex and multifactorial. Pregnancy clocks, partly controlled by timing mechanisms linked to fetal ... -
Internationally adopted children with unilateral cleft lip and palate - longitudinal perspectives on speech production and language ability
(2020-05-13)Many children with cleft lip and palate have been adopted to Sweden. Most had had no palatal closure performed in their native countries and received their first palatal surgery in Sweden while acquiring a new first language. ... -
Identification of novel antibiotic resistance genes through the exploration of mobile genetic elements
(2020-05-12)Backgrounds and aims: The evolution of multi-resistant pathogens is seriously threatening our ability to provide modern healthcare. Many of the mobile resistance factors in clinics appear to originate from environmental ... -
On tissue engineering of pig, human, and non-human primate tissues
(2020-05-07)Background: Demand for donor organs for transplantation has been increasing every year more than the actual supply of suitable donor organs. One of the major problems associated with allogeneic transplantation includes ... -
Cardiac arrest with emphasis on comorbidity and choice of treatment in acute coronary syndrome in the elderly
(2020-05-07)Background and aim: More data is required on survival and neurological outcome after in-hospital cardiac arrest (IHCA) in the elderly. The influence of comorbidity is often neglected in cardiac arrest research, particularly ... -
Primordial radionuclides in pit lakes in Sweden
(2020-05-07)In Sweden, there are many pit lakes, originating from limestone quarries and metal mines, with unknown status in regard to the activity concentration of radionuclides. Such knowledge is generally available only for pit ... -
Natural course and long-term prognosis in idiopathic Normal Pressure Hydrocephalus - the effect of delayed surgery and clinical factors on outcome and survival
(2020-05-07)Idiopathic Normal Pressure Hydrocephalus, iNPH, causes gait and balance difficulties, urinary incontinence and cognitive decline in mainly older persons and is treatable by insertion of a cerebrospinal fluid diverting ... -
Recurrent infection with Extended-Spectrum Beta-Lactamase (ESBL) -producing Enterobacteriaceae
(2020-05-05)Infections with Extended-Spectrum Beta-Lactamase (ESBL)-producing Enterobacteriaceae (EPE) are increasing globally. The most common EPE are the gut pathogens Escherichia coli (ESBL-E. coli) and Klebsiella pneumoniae (ESBL-K. ... -
Development and dynamics of the normal gut microbiota
(2020-05-05)Altered gut microbiota configurations have been linked to human diseases. To identify mechanistic links between altered gut microbiota and disease states, definitions of the healthy gut microbiota need to be established. ... -
Understanding the molecular mechanisms of bile acid receptor activation for the treatment of human liver disease
(2020-04-30)Farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and regulates bile acid homeostasis, glucose and lipid metabolism. FXR activation by a ligand has been identified as a therapeutic ...