Sahlgrenska Academy / Sahlgrenska akademin: Recent submissions
Now showing items 421-440 of 2677
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Clinical implementation of novel diagnostic biomarkers for epithelial ovarian cancer - Can we improve diagnosis?
(2020-04-01)Background: Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer. The 5-year survival is about 30%, a consequence of failure to establish early diagnosis due to unspecific symptoms. The biomarker serum ... -
Invasive treatment for intermittent claudication - clinical outcomes and cost-effectiveness
(2020-04-01)Intermittent claudication (IC) is caused by obstructive arterial lesions and is characterized by effort-induced pain in the lower extremity, limiting walking distance, and reduced health-related quality of life (HRQoL). ... -
Femoroacetabular Impingement Syndrome - Outcomes of Arthroscopic Hip Surgery
(2020-03-27)Hip and groin problems are common among young, active individuals. Femoroacetabular impingement (FAI) syndrome is an important cause of hip pain and reduced hip function among these patients. Bony abnormalities at the ... -
Functional studies of purinergic and cholinergic interactions in the rat urinary bladder - Characterization of ATP-evoked urothelial release of acetylcholine
(2020-03-26)Functional interplays between different transmitter systems are known to affect the signalling of the micturition reflex arc. The functional implications of many of these interactions, such as between ATP and acetylcholine, ... -
Immunological, vascular and metabolic actions of androgens
(2020-03-10)Men have higher prevalence of cardiovascular disease (CVD) but lower risk of autoimmune disorders than women. The actions of sex steroids may be involved in the sexual dimorphism of these diseases. Although testosterone, ... -
Dizziness and Benign Paroxysmal Positional Vertigo among older adults - health-related quality of life and associated factors
(2020-03-10)Dizziness is a common complaint reported by more than 30% of persons over 70 years of age and accounts for 2% of all visits in healthcare annually. Benign paroxysmal positional vertigo (BPPV) is a common and treatable cause ... -
Transplantation of normal and decellularized syngeneic, allogeneic and xenogeneic cardiac tissue in mice and non-human primates
(2020-03-05)Introduction Because of the restricted inherent capacity of regeneration and healing, transplantation is the only treatment for end-stage heart failure but it has limitations of donor shortage and graft rejection. Cardiac ... -
On the epidemiology, clinical presentation and transmission of respiratory viral infections
(2020-03-05)Respiratory viral infections encompass a large heterogenous group of pathogens that constitute a major burden of disease globally. The various routes of transmission including airborne spread make them difficult to control. ... -
Outcomes following primary total hip arthroplasty. With focus on the surgeon & surgeons' perceptions about feedback
(2020-03-05)Den övergripande målsättningen med det här avhandlingsarbetet var att utveckla en metodologi som förser ortopedkirurgen med information om sina egna resultat efter primär höftprotesoperation samt att undersöka effekterna ... -
Prevalance and prevention of sexually transmitted viral infections in the Bolivian Amazonas
(2020-03-05)This thesis investigates the prevalence of sexually transmitted viral infections in women living in the Amazonas region of Bolivia and explores whether Bolivian medical plants can affect the immune system and prevent or ... -
Socioeconomic aspects of lifestyle and women's health: a primary care and population perspective
(2020-03-05)Aims: To estimate growth characteristics and socioeconomic factors in relation to over-weight/obesity among 4-year-old children. To explore whether a primary care lifestyle programme reached and engaged socioeconomically ... -
Förekomst och behandling av smärta samt interventioner som bidrar till förbättrat smärtomhändertagande hos patienter på sjukhus
(2020-02-27)Background: Pain is common in hospitalized patients. Despite the availability of various treatment methods and effective drugs foroptimal pain alleviation, research has revealed that pain treatment remains suboptimal. Aim: ... -
The physiological processing of Alzheimer-associated amyloid beta precursor protein in human and animal-derived neuronal models
(2020-02-27)Alzheimer’s disease (AD) is characterized by cognitive impairment due to the loss of structure and/or function of neurons, and amyloid plaques composed of aggregated-amyloid beta (Aβ) peptides, primarily species ending at ... -
Ghrelin in feeding: new insights into its role and the neurocircuits involved
(2020-02-27)Appetite, originally evolved to ensure we consume enough of diverse nutrients to survive famines, has lost its survival advantage in our modern society, where food is plentiful. The hedonic aspect of appetite can indeed ... -
Cardiovascular outcomes and extra-articular manifestations in patients with spondyloarthritis
(2020-02-27)Background: Spondyloarthritis (SpA) is a cluster of rheumatic diseases with similar clinical features, including association with extra-articular manifestations such as anterior uveitis (AU), inflammatory bowel disease ... -
Kunskapsöversikter inom arbetslivsområdet
(Samhällsmedicin och folkhälsa, Göteborgs universitet, 2020-02-17)Böcker har traditionellt varit en vanlig form av kunskapsöversikt inom de flesta vetenskapsområden. Översikter har också sedan länge publicerats i vetenskap-liga tidskrifter i de flesta vetenskapsområden. Under slutet av ... -
Periprosthetic femoral fracture after total hip replacement. Incidence, risk factors, and treatment
(2020-02-18)This thesis investigates the incidence of surgically treated periprosthetic femoral fractures (PPFF) in Sweden between 2001 and 2011, the demography of this population, risk factors that may contribute to its occurrence ... -
Bipolar disorders: Subtypes, treatments, and health inequalities
(2020-02-18)This thesis comprises five studies based on prospective, longitudinal data from the Swedish national quality register BipoläR. Study I examined the differences between bipolar subtype I and II with respect to clinical ... -
Tumor cell heterogeneity profiling using single-cell analysis
(2020-02-13)Cancer is a diverse disease with large variations between tumor types and patients regarding tumor progression and prognosis. Additionally, most individual tumors are heterogeneous, containing subpopulations of cells with ... -
Sex steroids, IGF-I, and vascular morphology from birth to adulthood in individuals born small for gestational age
(2020-02-11)Abstract Aim: To study whether there is an association between size at birth, sex steroids, IGF-I, and retinal vascular morphology. Patients and methods: Two different cohorts were studied. In paper I, 25 young adult men ...