Sahlgrenska Academy / Sahlgrenska akademin: Recent submissions
Now showing items 561-580 of 2677
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Tumour evolution and novel biomarkers in breast cancer
(2019-04-30)Several gene signatures have been proposed in the past two decades to improve outcome prediction for breast cancer patients and to guide treatment decisions. Current treatment guidelines, however, primarily focus on ... -
Chronic Rhinosinusitis with Nasal Polyps - Symptoms, Heredity and Genetics
(2019-04-26)ABSTRACT Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by long-term inflammation of the paranasal sinuses combined with bilateral glassy protuberances from the middle meatus of the nasal cavity. This ... -
Chronic limb-threatening ischaemia - Prognosis after intervention
(2019-04-26)Introduction: Lower-extremity arterial disease (LEAD) is a major health problem worldwide. Chronic limb-threatening ischaemia (CLTI) is the most severe manifestation of LEAD. Open or endovascular recanalization is recommended ... -
Mild Cognitive Impairment - concepts, cut-offs, and clinical relevance
(2019-04-25)Mild cognitive impairment (MCI) is a diagnosis frequently used in dementia research and in memory clinics. MCI is meant to identify patients without dementia, but with cognitive decline beyond what is considered normal, ... -
Thymic studies. Investigations into the effects of childhood thymectomy, and characterization of thymic B cells and Hassall's corpuscles
(2019-04-23)This thesis focuses on the human thymus, a primary lymphoid organ responsible for the maturation of T cells. Progenitors arrive from the bone marrow and start to randomly assemble their T cell receptor (TCR) followed by a ... -
Nonsynostotic plagiocephaly: Prevention strategies in child health care
(2019-04-18)The aim of this project was to assess whether it is possible to prevent nonsynostotic plagiocephaly while still promoting safe infant sleeping practices. A continuing education including guidelines was developed for child ... -
Biomarkers for Alzheimer's disease and the APOE polymorphism
(2019-04-18)Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core pathology of AD are now widely used for diagnosis making, in particular β-amyloid[1-42] (Aβ42) ... -
Smoking and T cell co-stimulation in rheumatoid arthritis
(2019-04-18)In this thesis I investigated if smoking limits the co-stimulatory system of CD8+ T cells in rheumatoid arthritis (RA). I took special interest in the co-inhibitory receptor PD-1 and its ligand PD-L1. Blood samples from ... -
Ischemic Stroke Outcomes - Analyses of Protein and Genetic Biomarkers
(2019-04-18)The overall aim of this thesis was to identify novel biomarkers for ischemic stroke outcomes. The specific aims were to test the hypotheses that circulating concentrations of hemostatic biomarkers predict the long-term ... -
Strain echocardiography in the critically ill patient
(2019-04-12)In this thesis, strain echocardiography by two-dimensional speckle tracking imaging (2D-STI), was used for the evaluation of left ventricular (LV) and right ventricular (RV) function in critically ill patients with septic ... -
Investigations of human cortical processing of gentle touch. A study with time-resolved electro-magnetic signal analysis
(2019-04-12)The present work summarizes investigations of the temporal correlates of brain activity elicited by gentle, moving touch on the hairy skin in healthy participants and in epilepsy patients. Light touch to the hairy skin ... -
Strategies for optimisation of 177Lu-octreotate therapy – exploring local administration and combination therapy regimens
(2019-04-12)Neuroendocrine tumours (NETs) are a group of heterogeneous tumour types that originate in hormone-producing organs. Patients with NETs are often diagnosed after the primary tumour has metastasised. One treatment option for ... -
Invasive fungal disease in immunocompromised hosts with focus on diagnostics
(2019-04-12)Invasive fungal diseases (IFDs) are severe conditions affecting immunocompromised patients. The primary aim of this thesis was to explore different methods for diagnosis of IFD in different groups of immunocompromised ... -
Wearable sensors for monitoring epilepsy and Parkinson´s disease
(2019-04-11)Introduction: Epilepsy and Parkinson’s disease (PD) are conditions where management would benefit greatly from monitoring symptoms over longer time periods in natural everyday environments instead of only intermittent ... -
Surgical Management of Rib Fractures Following Trauma
(2019-04-08)Background: Surgical management of chest wall injuries has received increasing attention in recent years. The aim of this thesis was to study the mechanism of injury (MOI) in relation to chest wall injury patterns and ... -
Direct triaging to physiotherapist in primary care - development and evaluation of a triage model
(2019-04-05)Background: There is evidence that early contact with physiotherapists leads to advantages for patients with musculoskeletal disorders. Many patients, however, initially seek contact with general practitioners (GPs) within ... -
B cell subpopulations in the pathogenesis of rheumatoid arthritis
(2019-04-04)B cell depleting therapy has proven to be an effective treatment in rheumatoid arthritis (RA), a disease characterized by the presence of autoantibodies against citrullinated proteins (ACPA) and the Fc portion of IgG ... -
Children living with type 1 diabetes and congenital heart disease in the West Bank, Palestine -Self-perceived health status, sense of coherence, and the daily life experiences of these children and theri parents
(2019-04-04)Chronic diseases such as type 1 diabetes (T1D) and congenital heart disease (CHD) are lifelong conditions, need regular treatment, self management, and health care follow-ups. Growing up with these conditions affects the ... -
Female genital Graft-versus-Host Disease - Diagnosis, Treatment, Incidence, Long-term Prevalence, and Impact on Androgen Hormones and Sexual Function
(2019-03-28)ABSTRACT BACKGROUND. Chronic graft-versus-host disease (cGvHD) is the major cause of morbidity after allogeneic hematopoietic stem cell transplantation (alloSCT), and contributes to non-relapse mortality. Caused by donor ... -
In vivo and in vitro studies of polyetheretherketone: bone formation, inflammatory response and biofilm formation
(2019-03-22)In prosthetic dentistry, restorative materials are used to replace missing teeth and tissues, so as to maintain oral functionalities and comfort for the patient. Depending on the clinical problem, metals, ceramics or ...