Institute of Biomedicine / Institutionen för biomedicin
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Defining the pathways involved in spatial protein quality control in Saccharomyces cerevisiae
(2022-11-21)Proteins need to be folded into specific three-dimensional conformations to be functional. An extensive network of factors, the protein quality control (PQC) machinery, ensures that the cell maintains a healthy proteome ... -
On gastrointestinal viral infections
(2022-11-10)Gastrointestinal viral infections cause considerable morbidity and mortality worldwide. Many factors influencing clinical presentation, disease severity, epidemiology, and transmission are not fully understood. The aims ... -
Aloe barbadensis Mill. as a therapeutic option for irritable bowel syndrome – properties, bioactivity and mode of action
(2022-11-08)Irritable bowel syndrome (IBS) is a chronic and prevalent functional gastrointestinal disorder, with an incompletely understood pathophysiology. Because of the disease complexity and heterogeneity, the currently available ... -
BiolDentification of Alk-associated signaling complexes
(2022-10-25)Anaplastic lymphoma kinase (Alk) is a receptor tyrosine kinase (RTK) of the insulin receptor family. Alterations in human ALK signaling have been implicated in multiple malignancies including pediatric neuroblastoma. In ... -
Genetic studies of craniosynostosis with focus on syndromic forms
(2022-10-21)Craniosynostosis (CS) represents the premature closure of skull sutures and affects ~1 in 2500 children. Untreated CS can lead to significant complications in craniofacial and psychomotor development. The only treatment ... -
Molecular biosignatures and gut-barrier alterations in inflammatory bowel diseases
(2022-08-23)Inflammatory bowel diseases (IBD) are chronic immune-mediated disorders affecting the gastrointestinal tract. The multifactorial pathophysiology of IBD is commonly explained as an abnormal interplay between genetic, immune, ... -
Genetic determinants of lung cancer and their application toward therapeutics. The role of ZFP148 transcription factor and anaplastic lymphoma kinase (ALK) fusion proteins in non-small cell lung cancer
(2022-08-12)Lung cancer causes severe morbidity and mortality in millions of patients globally each year. Anaplastic lymphoma kinase (ALK) mutations facilitate neoplastic growth of lung cancer in adults and neuroblastoma in pediatric ... -
Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response
(2021)Cell fate decisions during early B cell activation determine the outcome of responses to pathogens and vaccines. We examined the early B cell response to T-dependent antigen in mice by single-cell RNA sequencing. Early ... -
Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection
(2022)Following infection or immunization, memory B cells (MBCs) and long-lived plasma cells provide humoral immunity that can last for decades. Most principles of MBC biology have been determined with hapten-protein carrier ... -
Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells
(2022)B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs after infection is lacking. Here, ... -
The transcriptomic landscape of Epstein-Barr virus associated tumors at cellular and single-molecule level
(2022-06-10)Epstein-Barr virus (EBV) was the first oncovirus found in humans. Almost all adults worldwide are asymptomatic carriers of EBV. The latent EBV-infection malignifies in approximately 200,000 individuals each year. The risk ... -
Viral proteins as serological antigens - Development and clinical applications
(2022-05-24)Serological methods are based on the detection of antibodies and antigens in mainly serum but also in other body fluids such as cerebrospinal fluid (CSF). Conventional whole virus antigens are widely used in viral serological ... -
Molecular and genetic studies of DLG2 in neuroblastoma and colorectal cancer
(2022-05-19)Neuroblastoma is one of the most common extra cranial solid tumors in children. It is one of the most common causes of death amongst the pediatric malignancies. There is however a large difference between the low risk ... -
lntestinal microenvironment, epithelial barrier interactions and human milk oligosaccharide supplementation in irritable bowel syndrome
(2022-05-19)Alterations of the microbiota-host interactions at the mucosal border may be of importance in symptom generation in irritable bowel syndrome (IBS), a disorder of gut-brain interaction. Hence, microbiota-targeted interventions ... -
ReCREating BRAF-driven thyroid and lung cancer in mice
(2022-05-17)Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer with a 3:1 female/male incidence. PTC is caused by oncogenic BRAF mutation encoding BRAFV600E in 50% of cases. Prognosis is mostly excellent post- ... -
Deregulated epigenetics and cancer stem cells in brain tumours
(2022-05-11)Glioblastoma (GBM) is an incurable brain tumour with dismal prognosis as the median survival for afflicted patients is only 8 months. Aberrations of epigenetic processes, which govern gene expression, are involved in cancer, ... -
Molecular and structural studies of proteins required for mitochondrial DNA maintenance
(2022-04-28)Mitochondria are membrane-bound organelles that produce the majority of ATP used to drive metabolic processes in eukaryotic cells. A unique feature of mitochondria is the existence of a separate mitochondrial DNA (mtDNA), ... -
3D Printed scaffolds as cancer microenvironment medels for drug discovery
(2022-04-05)Cancer is one of the most common diseases in the modern world and major efforts are made globally to develop new diagnostics and treatments. It originates from a cell which, at some point, has begun to divide and grow ... -
Next generation molecular diagnostics using ultrasensitive sequencing
(2022-03-15)Massively parallel sequencing enables the exploration of the genetic heterogeneity within microbial, viral and tumor cell populations. Detecting circulating tumor DNA in blood and other body fluids has the potential to ...
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