Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi: Recent submissions
Visas titlar 101-120 av 437
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Metabolic and immunological interactions between adipose tissue and breast cancer - implications of obesity in tumor progression
(2019-10-16)Triple-negative breast cancers have fewer treatment options than other breast cancers. The overall goal of this research is to identify new pharmaceutical targets for triple-negative breast cancer through studies of the ... -
Participation after stroke in a short- and long-term perspective
(2019-10-15)The main scope of this thesis was to study and describe perceived participation among persons with stroke. In doing so, different timepoints were chosen to make a more complete picture of participation after stroke. The ... -
Neurofilaments as biomarkers of neuronal damage
(2019-09-24)Different neurodegenerative diseases have overlapping symptomatology and pathology and have thus become a challenge to modern medicine to achieve a correct diagnosis. The aim of the thesis was to evaluate the use of ... -
Adipose tissue mitchondrial function is modulated by antioxidants
(2019-09-23)Antioxidants are widely used as reactive oxygen species (ROS) scavenging agents in experimental research and in conditions where oxidative stress plays a primary role. However, the effect of antioxidant supplementation ... -
Generalized anxiety disorder (GAD) and anxiety symptoms in older adults
(2019-09-11)Anxiety is a broad concept, difficult to detect and recognize. Expression may shift over the lifetime further complicating identification. Generalized Anxiety Disorder (GAD) is one of the most common anxiety disorders in ... -
Tau fragments: role as biomarkers and in the pathogenesis of Alzheimer's disease and other tauopathies
(2019-09-10)Abstract Tau protein is physiologically expressed in neurons, where it is involved in microtubule assembly and stability. Tau functions are rigorously regulated by a series of modifications, e.g. phosphorylation and ... -
Biochemical markers in dementia - Exploring Swedish registry data and the human proteome
(2019-09-04)Cerebrospinal fluid (CSF) biomarkers of neurodegenerative diseases have a wide scope of applications in diagnostics, prognosis assessment, disease staging, treatment evaluation and more. In this PhD project we aimed to ... -
Multimodal Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
(2019-08-30)Alzheimer’s disease (AD) is the most common form of dementia. AD has been linked to the aggregation of amyloid beta (Aβ) peptides into extracellular deposits, Aβ plaques. These are also found in cognitively unimpaired ... -
Molecular perspectives on glomerular cell physiology in chronic kidney disease
(2019-05-24)Glomerulonephritis is one of the most common causes of chronic kidney disease (CKD) in the world. Recent establishment of guidelines for classification of CKD in five stages has led to increased awareness of the risks of ... -
On cognition and personality in bipolar disorder
(2019-05-24)Even though the hallmark of bipolar disorder is recurrent episodes of elevated or depressed mood, mounting evidence suggests that cognitive impairment is a prominent characteristic of bipolar disorder. The heterogeneity ... -
On Neuroimmunology and Brain Function: Experimental and Clinical Studies
(2019-05-23)The immune system has been implicated in the mechanisms underlying many psychiatric disorders. Immune mediators are expressed in the central nervous system (CNS) not only in response to harmful stimuli, but also in a ... -
CSF biomarkers in idiopathic normal pressure hydrocephalus- Diagnostics and pathophysiology
(2019-05-23)Idiopathic normal pressure hydrocephalus (iNPH) is a disease of the elderly with enlarged ventricles despite a normal CSF pressure. Clinically, iNPH presents with gait- and balance disturbances, cognitive decline and ... -
In vivo responses of neural progenitor cells to extracellular matrix signaling under pathological conditions
(2019-05-23)The adult brain has an inherently low capacity for tissue regeneration, and neurons lost to disease or injuries are normally not replaced. This becomes especially apparent when stroke or brain trauma occurs. The discovery ... -
Effects of PGC1a-induced exercise adaptations in muscle on plasticity and recovery mechanisms in the CNS
(2019-05-17)In this thesis, we sought to determine if muscle-derived exercise-induced signaling via PGC-1α muscle activation influences neuroplasticity under physiological or pathophysiological conditions. For this purpose, transgenic ... -
Precision in neuropsychology. Four challenges when using simplified assumptions
(2019-05-16)Cognition comprises all thought processes, from perception to memory. Neuropsychological tests are the gold standard (= best way) to measure cognition. However, clinical assessment may at times have to rely on simplified ... -
Patience you must have, my young athlete - Rehabilitation specific outcomes after anterior cruciate ligament reconstruction
(2019-05-07)An anterior cruciate ligament (ACL) injury is one of the most common knee-related injuries, usually occurring in younger individuals during sports participation. Moreover, almost 1 in 4 of younger athletes sustain a ... -
Increasing the interpretability of Alzheimer-related biomarkers: cell- and cerebrospinal fluid-based studies with focus on neurogranin
(2019-05-07)Biomarkers for Alzheimer’s disease (AD) is a growing field of research. A particularly vibrant field during recent years has been biomarkers for synaptic dysfunction. Sensitive assays for a synaptic protein called neurogranin ... -
Mild Cognitive Impairment - concepts, cut-offs, and clinical relevance
(2019-04-25)Mild cognitive impairment (MCI) is a diagnosis frequently used in dementia research and in memory clinics. MCI is meant to identify patients without dementia, but with cognitive decline beyond what is considered normal, ... -
Biomarkers for Alzheimer's disease and the APOE polymorphism
(2019-04-18)Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core pathology of AD are now widely used for diagnosis making, in particular β-amyloid[1-42] (Aβ42) ... -
Investigations of human cortical processing of gentle touch. A study with time-resolved electro-magnetic signal analysis
(2019-04-12)The present work summarizes investigations of the temporal correlates of brain activity elicited by gentle, moving touch on the hairy skin in healthy participants and in epilepsy patients. Light touch to the hairy skin ...