Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi: Recent submissions
Visas titlar 201-220 av 437
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Mass spectrometric quantification of amyloid-beta in cerebrospinal fluid and plasma
(2015-10-07)Alzheimer’s disease (AD) is the most common neurodegenerative disease among the elderly and accounts for 60-80% of all cases of dementia. Currently, the diagnosis of AD is based on cognitive tests and mental state exams, ... -
Effects and experiences of exercise during pregnancy
(2015-09-25)Background: Recommendations regarding intensity, duration and type of exercise during pregnancy vary worldwide. Most research on exercise during pregnancy investigates the effects of aerobic exercise while only a few trials ... -
Speech, Language and Communicative Ability in School-Aged Children with Cerebral Palsy and Speech Impairment
(2015-09-10)Abstract: The overall aim of this thesis was to explore and describe speech, language and communicative ability in school-aged children with cerebral palsy (CP) and speech impairment. The medical records of a population-based ... -
Comparative in vivo pharmacology of dopidines A novel class of compounds discovered by phenotypic screening
(2015-09-10)Dopidines are a novel class of dopamine (DA) modulating compounds, developed to provide improved treatment of a range of neurodegenerative and psychiatric disorders that are currently managed to a large extent with ... -
The impact of glucagon-like peptide-1 on the brain-reward system and beyond
(2015-09-09)Glucagon-like peptide-1 (GLP-1), produced in the intestine and the brain, regulates food intake and glucose metabolism. A GLP-1 based treatment is already approved for clinical use in type 2 diabetes patients, and recently ... -
Pharmacokinetics of artemisinin derivatives in rats, healthy volunteers and patients
(2015-09-04)Malaria is still a major health problem, killing approximately 1,600 people each day. The most vulnerable patient groups are children under the age of five and pregnant women. Artemisinin-based combination therapy is ... -
Psychiatric symptoms and disorders in old age: prevalence, course and diagnostic thresholds
(2015-09-04)The aim of this thesis was to study the epidemiology of some psychiatric disorders, as well as their corresponding subthreshold symptoms, in order to explore the border between psychopathology and normality in the general ... -
Prediagnostic and comorbidity factors in preschool children with autism
(2015-08-31)The aim of the thesis was to investigate Autism Spectrum Disorder (ASD) diagnosed in the early years from different angles; screening, load of coexisting disorders, outcome at routine developmental surveillance, and to ... -
On the anxiogenic influence of serotonin
(2015-06-04)Despite over half a century of research on the role of serotonin in modulating anxiety, no consensus exists as to if serotonin should be regarded as acting mainly anxiety-dampening or anxiety-enhancing. This question is ... -
Navigating towards a self-determined daily life in old age. Experiences, instrument evaluation and explanatory factors.
(2015-05-18)Aim: The overall aim of this thesis was to explore self-determination in the context of community-dwelling older persons with different degrees of dependence in daily activities. Methods: Using a qualitative, grounded ... -
Frontotemporal dementia in late life: Prevalence, risk factors and mortality
(2015-05-18)Aims: The overall aim of this thesis was to increase knowledge about late-life behavior variant frontotemporal dementia (bvFTD). One aim was to estimate the prevalence of bvFTD among older adults and to determine the ... -
Moved by movement: A person-centered approach to physical therapy in the treatment of major depression
(2015-05-12)Major depression (MD) is a common and debilitating condition. To expand knowledge on adjunctive treatment perspectives, this thesis explores a physical therapy approach in the treatment of MD. Specifically, in five studies, ... -
The supporting conversation partner in disordered communication
(2015-05-06)Abstract: The overall aim of the thesis was to examine some aspects of conversation partners (CP) of people with communication disorder caused by stroke-induced aphasia or Parkinson’s disease (PwCD). Central questions ... -
Comorbidity across childhood-onset neuropsychiatric disorders
(2015-04-22)Background: Attention-Deficit/Hyperactivity Disorder (ADHD), and Autism Spectrum Disorders (ASDs) are clinically found to be comorbid with each other and with other psychiatric conditions to a greater extent than what is ... -
Ethanol-induced modulation of dopamine transmission and synaptic activity in striatal subregions - focus on inhibitory receptors
(2015-04-17)Background: Alcoholism is a chronic brain disease, affecting neurocircuitries involved in reward and learning. The rewarding effects of alcohol (ethanol) are believed to result from increased dopamine levels in the nucleus ... -
On Complications to Cataract Surgery
(2015-04-08)Cataract surgery, meaning exchange of the opaque lens in the eye with an artificial lens, is nowadays one of the most successful surgical procedures ever known. It is also the most frequent surgery performed in the Western ... -
Re-evaluation of the hypothesis that LTP has two temporal phases and that the late phase is protein synthesis-dependent
(2015-02-19)Long-term potentiation (LTP) is an activity-dependent increase in synaptic efficacy that is most studied in the hippocampus and that is considered a cellular substrate for learning and memory. Accepting the belief that the ... -
Bestrophin-3: Localization and function in normal and injured tissues
(2015-02-05)Bestrophin-3 (Best3) is a protein with multiple functions. It can constitute a calcium-activated chloride channel when overexpressed in cultured cells, but the function of Best3 is not well studied in cells in situ. Recently ... -
Discovering the capabilities of ageing persons who are born abroad: crossing norms, moving health promotion forward
(2015-01-30)To improve the possibilities for the whole population to take control over their health is an important goal for health promotion and public health. Yet, with improved possibilities for international migration and extended ... -
Cognition, Adherence and Stigma in Schizophrenia. The COAST study
(2015-01-26)Schizophrenia is a serious stigmatizing illness. Antipsychotic medication is a cornerstone in treatment. Non-adherence is a predictor of poor outcome leading to relapse, poor functioning, high mortality and costs. Reported ...