Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi: Recent submissions
Visas titlar 301-320 av 437
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Attention-deficit/hyperactivity disorder and autism spectrum disorders in adult psychiatric patients
(2011-11-25)Background: Knowledge about attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) in adult psychiatry is scant. Aims: Estimate prevalence, psychiatric morbidity patterns and impact of ADHD/ASD ... -
CSF biomarkers reflecting beta-amyloid and axonal pathology in Alzheimer's disease and related conditions
(2011-11-18)Cerebrospinal fluid (CSF) biomarkers may be used to identify and monitor pathological processes in the central nervous system. CSF biomarkers in Alzheimer’s disease (AD) include β-amyloid 42 (Aβ42), total-tau (T-tau) and ... -
Inflammation in the immature brain: The role of Toll like receptors
(2011-10-28)Infection/inflammation and/or hypoxia-ischemia (HI) are major causes of perinatal brain injury. Toll-like receptors (TLRs), important components of innate immunity, have been shown to be involved in brain injury, both after ... -
Visual function and ocular morphology in children with surgically treated hydrocephalus
(2011-09-30)Abstract Aims To investigate the frequency of ophthalmological abnormalities, the need and timing of eye-care interventions as well as incidence, aetiology and neurological/neuropsychological outcomes in children with ... -
To get things done, the challenge in everyday life for children with spina bifida. Quality of performance, autonomy and participation
(2011-09-05)The overall aim of this thesis was to increase knowledge of the quality of performance of everyday activities, autonomy and participation in children with spina bifida (SB) and to explore how they relate to each other. Methods: ... -
Executive dysfunctions in elderly persons with mild stroke
(2011-06-13)ABSTRACT The overall aim of this thesis was to examine the performance of personal activities of daily living (P-ADL) related to cognitive and executive dysfunctions in elderly patients with mild stroke in the acute ... -
Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and Vascular dementia
(2011-05-27)Patients suffering from mild cognitive impairment (MCI) run a higher risk of developing dementia, with Alzheimer’s disease (AD) being the most common form. Vascular dementia (VaD) is proposed to be the second most common ... -
Fetal reactivity assessment during intrapartum stress by analysis of the fetal ECG signal
(2011-05-27)Fetal responses to the stress of labour and delivery are constituted by a combination of changes in neuronal, hormonal and organ based reactions. The aim of electronic fetal monitoring is to identify fetuses at risk of ... -
Modelling of tolerance and rebound in normal and diseased rats
(2011-05-27)The development of rebound and tolerance is an important consideration when optimizing medical therapy, both with respect to drug dosing and adverse effects. By using quantitative approaches to study these processes, ... -
The neuropsychology of idiopathic normal pressure hydrocephalus
(2011-05-09)Idiopathic normal pressure hydrocephalus (iNPH) is characterised by an active distension of the cerebral ventricles due to inadequate absorption of cerebrospinal fluid (CSF) into the systemic circulation. The intracranial ... -
Measuring the tactile sense: Cortical mechanisms and clinical applications of tactile direction discrimination
(2011-03-18)Most of the studies aiming to investigate the human tactile sense are done on the glabrous skin. Still, there is a need for a quantitative method for evaluating nervous function of the hairy skin. Tactile direction ... -
Brain glycine receptors as a common target for alcohol and the relapse-preventing drug acamprosate - a preclinical study
(2011-03-08)Alcohol abuse and dependence make up the most prevalent categories of substance use disorders in the world. Converging evidence from the current research group has identified two receptor populations, the glycine (GlyRs) ... -
Reactive gliosis in the injured brain: The effect of cell communication and Nrf2-mediated cellular defence
(2011-02-18)Stroke and other brain injuries trigger an extensive glial cell response referred to as reactive gliosis. Reactive gliosis is characterized by hypertrophic and proliferating astrocytes, proliferating microglia and NG2-positive ... -
Dendritic cells in cancer immunotherapy
(2011-02-16)Dendritic cells (DCs) play a central role in the initiation and regulation of innate and adaptive immune responses and have increasingly been applied as vaccines for cancer patients. Ex vivo generation and antigen loading ... -
The challenge of communication during home mechanical ventilation
(2011)The overall aim of this thesis was to explore and describe experience of communication during home mechanical ventilation (HMV) in adults, thereby contributing to increased knowledge and awareness of issues related to ... -
Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence
(2011-02-02)Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter ... -
Muscle diseases with damaged sarcomeres - causes and consequences
(2011-01-19)Muscle diseases, also called myopathies, are usually defined as diseases where the pathology is confined to the muscle itself. This excludes diseases caused by structural abnormalities in the peripheral nerve, from the ... -
On the importance of inflammation for personality traits and psychiatric morbidity
(2010-12-10)Background: Pro-inflammatory mediators have been implicated in processes that could be both beneficial and toxic to cells in the brain. On the one hand balanced levels of these mediators favour e.g. neurodevelopmental ... -
Muscarinic receptors in the urinary bladder - The role of the urothelium regarding cholinergic and nitrergic effects in inflammation
(2010-11-19)Inflammation alters the functional properties of the urinary bladder. Interstitial cystitis (IC) is a chronic inflammatory syndrome in man that is characterized by urgency, frequency and visceral pain. The overall aim of ... -
Physiotherapists in Afghanistan. Exploring, encouraging and experiencing professional development in the Afghan development context
(2010-10-25)Aim: The aim of the thesis is to analyze the matter of supporting professional development of physiotherapists in Afghanistan, and the issues involved in expatriate physiotherapists working with professional development ...