Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi: Recent submissions
Now showing items 321-340 of 437
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On the Regulation of the Serine Protease t-PA and its Inhibitor PAI-1 in the Brain
(2010-09-28)The serine protease tissue-type plasminogen activator (t-PA) is the main fibrinolytic enzyme in the vascular system, and thus plays a critical role in the dissolution of thrombi. In recent years, researchers have focused ... -
Attitude to Speech and Communication in Individuals Born with Cleft Lip and Palate
(2010-09-23)The overall aim of this thesis was to explore and describe how individuals who are born with a cleft lip and palate experience their communicative situation, how they perceive their speech and whether their views correlate ... -
Respiratory burst and severity of demyelinating diseases
(2010-09-23)Multiple sclerosis (MS) and the Guillain-Barré syndrome (GBS) are tissue-specific inflammatory diseases of the central and the peripheral nervous system, respectively. A contemporary analysis infers that these are complex ... -
Hippocampal volumetry in mild cognitive impairment
(2010-09-10)Dementia is a syndrome with cognitive decline as a prominent feature. MCI is similarly a syndrome of cognitive decline, albeit with much subtler symptoms, and has been identified as a condition at risk for progression to ... -
Girls with social and/or attention impairments
(2010-09-03)Background: This study set out to increase knowledge about the clinical presentation, impairment level, associated problems, and screening/identification of girls coming to clinics with non-specified social and/or attention ... -
Differences in glutamatergic transmission onto interneurons and pyramidal cells in the rat hippocampus
(2010-09-03)In the human brain there are about 100 billion excitatory glutamatergic neurons and 10 billion inhibitory GABAergic neurons. During development, these neurons are synaptically wired together into neural networks, functionally ... -
Inflammation and Cell Profileration Following Perinatal Brain Injury
(2010-08-30)Inflammation plays an important role in cerebral ischemic injury in the immature brain. The aim of the thesis was to investigate (1) the role of astrocyte activation and reactive gliosis in neonatal hypoxic-ischemic (HI) ... -
Behavior and cytogenesis following irradiation or isoflurane exposure to the developing brain
(2010-08-30)In this thesis, the effects of an anesthetic agent, isoflurane, on the young brain and resulting behavioral effects were investigated. Anesthesia is commonly used in young children during surgery or other procedures ... -
Cytokines and lipids in pregnancy – effects on developmental programming and placental nutrient transfer
(2010-08-12)Metabolic disturbances, in particular those associated with nutritional challenges, that take place during development, both in utero and early postnatal life, have long-lasting health consequences on an individual. The ... -
Short- and long-term neuronal plasticity in hippocampal CA1 region of rat
(2010-06-14)The brain is highly plastic, displaying both short- and long-term changes, resulting from developmental processes as well as learning and memory. Moreover, short-term plasticity such as paired pulse facilitation and ... -
Living with ALS – Perspectives of Patients and Next of kin
(2010-05-28)ALS is a neurodegenerative disease without curative treatment. The knowledge of the relationship between patients and their next of kin with respect to quality of life (QoL) is deficient. The overall aim of this thesis is ... -
Outcome after modern neurosurgical care and formalised rehabilitation following severe brain injury
(2010-05-28)Aims: The overall aims were to evaluate the results of the treatment concepts for severe brain injury including decompressive craniectomy (DC), early rehabilitation and long-term follow-up, primarily according to the ... -
Orofacial dysfunctions in children and adolescents with myotonic dystrophy type 1 - evaluation and intervention
(2010-05-12)Myotonic dystrophy type 1 (DM1) is a slowly progressive neuromuscular disease. The overall aim of this thesis was primarily to describe the characteristics, prevalence, and development of orofacial functions in a group of ... -
Physiotherapy after surgery in patients with subacromial pain – an evaluation of functional outcome and health-related quality of life in the mid- and long-term perspective
(2010-05-11)Background: No consensus exists regarding physiotherapy treatment after surgery in patients with subacromial pain. There are only a few randomised, controlled studies that evaluate outcome after different physiotherapy ... -
Longitudinal cognitive changes in medically and surgically treated patients with drug resistant partial epilepsy
(2010-04-27)When this study was initiated, there were few published longitudinal studies on cognition in medically treated patients with refractory epilepsy, and none included reassessment data from healthy controls. At the time there ... -
Reward-related genes and alcohol dependence
(2010-04-13)Introduction: The rewarding properties of alcohol are mediated by the brain reward systems, specifically by the cholinergic-dopaminergic reward link, involving both nicotinic acetylcholine receptors (nAChRs) as well as the ... -
The reserve concept in patients with Mild Cognitive Impairment - new approaches
(2010-03-26)The concept of reserve stems from the observation that premorbid factors, e.g. education, result in variation in the response to any kind of brain pathology. As subjects with higher reserve tolerate more neuropathology, ... -
Speech and language dysfunction in childhood epilepsy and epileptiform EEG activity
(2010-03-05)In severe childhood language disorder, concomitant dysfunction in other areas may be present. There are indications that epileptiform EEG activity and epilepsy may influence speech and language development, but this ... -
Thin-fibre signalling in humans: Cortical processing of sensory afference and autonomic efference
(2010-03-04)Thin nerve fibres innervate the entire human body and mediate sensations such as pain, temperature and visceral sensory input. Moreover, a special class of unmyelinated afferents responsive to light touch has recently ... -
Genetics of Parkinson's disease - with focus on genes of relevance for inflammation and dopamine neruon development
(2010-02-18)Abstract GENETICS OF PARKINSON’S DISEASE - WITH FOCUS ON GENES OF RELEVANCE FOR INFLAMMATION AND DOPAMINE NEURON DEVELOPMENT Introduction: The risk to be affected by Parkinson’s disease (PD) is considered to be ...