Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi: Recent submissions
Now showing items 341-360 of 437
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Developmental plasticity of the glutamate synapse: Roles of low frequency stimulation, hebbian induction and the NMDA receptor
(2010-01-26)The glutamate synapse is by far the most common synapse in the brain and acts via postsynaptic AMPA, NMDA and mGlu receptors. During brain development there is a continuous production of these synapses where those partaking ... -
Polycystic ovary syndrome - Studies of metabolic and ovarian disturbances and effects of physical exercise and electro-acupuncture
(2010-01-15)Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in premenopausal women. The syndrome is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian (PCO) morphology. Metabolic ... -
Inflammation in experimental neonatal brain injury and in a clinical study of preterm birth; involvement of galectin-3 and free radical formation
(2010-01-08)Introduction; Intrauterine infection/inflammation is associated with preterm delivery (PTD) and severe neonatal morbidity. Inflammation is also important in the secondary neurotoxic cascade leading to perinatal brain injury. ... -
On the use of genomics to assess environmental risks of pharmaceuticals
(2009-12-17)Many drugs are found in the aquatic environment and are therefore a cause for concern. Low concentrations of active ingredients from human pharmaceuticals reach the environment via sewage treatment plants, mainly as a ... -
Regulation of postnatal neurogenesis and brain angiogenesis by thyroid hormone
(2009-12-07)Thyroid hormone (TH), which is secreted by the thyroid gland, exerts significant effects on the central nervous system (CNS), especially during development, so that delayed treatment of perinatal hypothyroidism results ... -
BACK TO ONESELF Sensory Motor Learning applied in patients with nonspecific chronic low back pain
(2009-12-04)Back pain is an endemic problem affecting one in five adults every year. Even though only 10 % of all cases of back pain become chronic it is one of the largest health problems in industrialized societies. The term nonspecific ... -
Susceptibility genes in conformational diseases
(2009-12-04)Conformational diseases are characterized by protein misfolding and aggregation in the affected tissue. The aim of this thesis was to find genetic support for mechanisms in common for three prevalent confor-mational diseases: ... -
Interactions between nutrition, obesity and the immune system
(2009-11-22)There are several links between body fat and the immune system. For example, mice lacking activity of the pro-inflammatory interleukin-(IL)-1 and IL-6 develop obesity. Conversely, obesity is associated with adipose tissue ... -
On The Innervation of Salivary Glands and Treatment of Dry Mouth - An Experimental and Clinical Study
(2009-11-19)Detailed knowledge of the innervation of the parotid gland is essential in basic studies on various neuroglandular phenomena as well as in various types of orofacial surgery. The innervation is more complex than usually ... -
On the influence of dopamine-related genetic variation on dopamine-related disorders
(2009-11-13)Rationale: Dopamine synthesizing neurons are involved in a wide variety of functions. The most prominent dopamine pathways originate in the midbrain. The development, function and survival of these dopaminergic neurons are ... -
The role of progesterone in the regulation of ciliary activity in the fallopian tube
(2009-11-13)The overall aim of this thesis was to investigate the distribution and regulation of membrane progesterone receptors (mPRs) that may be involved in regulating ciliary activity in the fallopian tube. The fallopian tube ... -
A pathway for pleasant touch: linking peripheral receptors to central processing and hedonic experience
(2009-11-10)This thesis investigates the mechanisms underpinning pleasant touch, describes a pathway from peripheral nerve endings in the skin to the insular cortex, and relates these findings to the subjective hedonic experience of ... -
Machine learning for identification of brain activity patterns with applications in gentle touch processing
(2009-10-23)Since the first mention of artificial intelligence in the 1950s, the field of machine learning has provided increasingly appealing tools for recognition of otherwise unintelligible pattern representations in complex data ... -
On the Stereoselective Pharmacokinetics of Eflornithine and Prediction of Drug Tissue to Plasma Concentration Ratios
(2009-09-18)Eflornithine is one of two registered drugs for the treatment of late-stage human African trypanosomiasis, a uniformly fatal neglected disease with sixty million people are at risk of being infected. Eflornithine is ... -
Strength training for physical performance and injury prevention in sports. Individualised and supervised training for female athletes.
(2009-09-18)The overall purpose of this thesis was to obtain knowledge about individualised, supervised strength and conditioning programmes for physical performance and injury prevention in female athletes. Data are presented both ... -
Secretory and anti-inflammatory actions of some gastro-intestinal hormones in salivary glands
(2009-09-17)Textbooks generally state that the secretory activity of salivary glands is solely regulated by nerves. This view is challenged in the present Thesis, using the parotid gland of the anaesthetized rat as experimental in ... -
Cold feet in children with neurological disorders
(2009-09-11)These studies focused on presence of cold feet in children with neurological disorders and raised the questions: Does acupuncture affect skin temperature? Are cold feet a general symptom in children with neurological ... -
Astrocyte-mediated short-term synaptic depression
(2009-09-09)Short-term synaptic plasticity, the activity-dependent regulation of synaptic efficacy that occurs in the timeframe of milliseconds to seconds, is a fundamental property of the synapse, mostly attributed to changes in ... -
Targeted Abeta proteomics - A tool to study the pathogenesis of Alzheimer's disease
(2009-09-04)Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder of the central nervous system. Diagnosis and monitoring of sporadic AD has long depended on clinical examination of individuals with end-stage ... -
Inflammation and behavior following irradiation-induced injury in the developing brain
(2009-08-28)Radiotherapy is used in the treatment of pediatric brain tumors and is often associated with debilitating late effects, such as intellectual impairment. Areas in the brain harboring stem cells are particularly sensitive ...